FNS  Vol.6 No.10 , July 2015
Effect of Diet Supplementation with Food Industry By-Products on Diabetic Rats
Abstract: The present research work aimed to study the effects of 3 nutritional food industry by-products (orange peels, peanut skin peels and pomegranate peel) on regulating blood glucose level. 66 male adult Sprague-Dawely rats weighing 125 ± 5 g each were used. These rats were injected with alloxan for inducing diabetes. The negative control group consisted of rats fed on basal diet, while the positive control group consisted of (3 - 11) sub-groups fed on basal diet in addition to 5%, 7.5% and 10% of nutritional food industry by-products. After 4 weeks the effect of the different experimental diets on body weight gain, organs relative weight, blood glucose level, liver functions and kidney functions was recorded for the negative group and all the positive sub-groups. The results revealed that there was non-significant difference between all relative organ weights of liver, kidney and pancreas compared to control negative. Blood glucose level significantly decreased in all sub-groups compared to the control positive group.
Cite this paper: Elhardallou, S. , Babiker, W. , Sulieman, A. and Gobouri, A. (2015) Effect of Diet Supplementation with Food Industry By-Products on Diabetic Rats. Food and Nutrition Sciences, 6, 875-882. doi: 10.4236/fns.2015.610092.

[1]   Mongeau, R. and Brassard, R. (1989) A Comparison of Three Methods for Analyzing Dietary Fiber in 38 Foods. Journal of Food Composition and Analysis, 2, 189-199.

[2]   Moussa, M., Limaee, N.Y, Mahmoodi, N.M. and Tabrizi, N.S. (1992) Fruits and Vegetables Contain a Variety of Antioxidant. Journal of Colloid and Interface Science, 288, 371-376.

[3]   Rosenbloom, A.L. and Silverstein, J.H. (1998) Diabetes in Children and Adolescents: A Clinician’s Guide to Diagnosis, Epidemiology, Pathogenesis, Prevention, and Treatment. American Diabetes Association, Alexandria, Virginia, 1.

[4]   Vivian, M. (2006) Diabetes Mellitus: Is Differentiation into Insulin-Sensitive and Insulin-Insensitive Types. The Lancet, 227, 127-130.

[5]   Gabriele, R. and Angela, R. (1991) Effects of Dietary Fiber and Carbohydrate on Glucose and Lipoprotein Metabolism in Diabetic Patients. Diabetic Care, 14, 1115-1125.

[6]   Kiehm, T.G,, Anderson, J.W. and Word, K. (1976) Beneficial Effects of a High-Carbohydrate, High Fiber Diet on Hyperglycemic Diabetic Men. The American Journal of Clinical Nutrition, 29, 895-899.



[9]   Ismail, T., Sestili, P. and Akhtar, S. (2012) Pomegranate Peel and Fruit Extracts: A Review of Potential Anti-Inflam- matory and Anti-Infective Effects. Journal of Ethnopharmacology, 143, 379-405.

[10]   Buko, V., Lukivskaya, O., Nikitin, V., Tarasov, Y., Zavodnik, L., Borodinsky, A., Gorenshtein, B., et al. (1996) Hepatic and Pancreatic Effects of Polyenoylphosphatidylcholine in Rats with Alloxaninduced Diabetes. Cell Biochemistry and Function, 14, 131-137.

[11]   Nakatsu, B.A., Abraham, A. and Leelamma, S. (1984) Antioxidant Effects of Some Plants in Rats Fed with High Fat Diet. Indian Journal of Experimental Biology, 35, 148-150.

[12]   Champman, M.L., Vergara, J.M., Romero, A.L., Evickson, S.K. and Mc Namara, D.J. (1959) Gender Differences in Response to Dietary Soluble Fiber in Guinea Pigs: Effect of Pectin, Guar Gum and Psyllium. The Journal of Lipid Research, 36, 2191-2202.

[13]   Trinder, D.M. (1969) Choline in the Nutrition of Chicks. The Journal of Biological Chemistry, 138, 459-470.

[14]   Reitman, S. and Frankel, S. (1957) A Colorimetric Method for the Determination of Serum Glutamic Oxalacetic and Glutamic Pyruvic Transaminases. American Journal of Clinical Pathology, 28, 56-63.

[15]   Bingham, S.A., Day, N.E., Luben, R., et al. (1960) Dietary Fiber in Food and Production against Cholesterol in the European Prospective Investigation into Cholesterol and Nutrition (EPIC): An Observational Study. The Lancet, 361, 1496-1499.

[16]   Barties, S. and Bohmer, D. (1972) Epidemiology of Diabetes Interventions and Complications Study on the Use of Intensive Glycemic Treatment to Reduce the Risk of Complications of Type 1 Diabetes. Endocrine Practice, 12, 34-41.

[17]   Caraway, H.M. (1995) The Effect of Some Fruit Peels on Serum Lipid. European Journal of Clinical Nutrition, 56, 1094-1101.

[18]   Babio, N., Balanza, R., Basulto, J., Bulló, M. and Salas-Salvadó, J. (2010) Dietary Fibre: Influence on Body Weight, Glycemic Control and Plasma Cholesterol Profile. Nutricion Hospitalaria, 25, 327-340.

[19]   King, B.J. (2005) Your Ultimate Guide to Abundant Energy. Health Venture Publications, Acton, ON.

[20]   Krowlewski, A.S., Warram, J.H., Rand, L.I. and Kahn, C.R. (1987) Epidemiologic Approach to the Etiology of Type I Diabetes Mellitus and Its Complications. The New England Journal of Medicine, 26, 1390-1398.

[21]   Pyorala, K., Loast, M. and Uusitupa, M. (1987) Diabetes and Atherosclerosis: An Epidemiological View. Diabetes/ Metabolism Reviews, 3, 463-524.

[22]   Diabetes Drafting Group (1985) Prevalence of Small Vessel Disease and Large Vessel Disease in Diabetic Patients from 14 Centers: The WHO Multinational Study of Vascular Disease in Diabetics. Diabetologia, 28, 715-740.

[23]   Kiehm, T.G., Anderson, J.W. and Word, K. (1976) Beneficial Effects of a High-Carbohydrate, High Fiber Diet on Hyperglycemic Diabetic Men. The American Journal of Clinical Nutrition, 29, 895-899.