Contrast-Enhanced Ultrasonographic Detection and Dual-Phase Computed Tomographic Angiography in a 5-Year-Old Boxer with Pancreatic Insulinoma —Case Report

Vilma  Reunanen; Merja  Laitinen

doi:10.4236/ojvm.2015.57024

Vilma Reunanen¹^*, Merja Laitinen²

Abstract: This case report describes the findings in a canine histopathologically confirmed pancreatic insulinoma using contrast-enhanced ultrasound (CEUS) and dual-phase computed tomographic angiography (CTA). The insulinoma was better demarcated in CEUS and CTA compared with conventional B-mode ultrasound. On the other hand, only one of two nodules visible in CTA was detected in CEUS. In this case, the insulinoma had an atypical non-contrast-enhancing appearance in both CEUS and CTA. Lack of enhancement in CEUS and CTA has previously been reported in human and canine studies, but this was the first report using both CEUS and CTA for detecting canine insulinoma.

Keywords: Pancreas, Insulinoma, Dog, Contrast-Enhanced Ultrasound, Contrast-Enhanced Computed Tomography

Cite this paper: Reunanen, V. and Laitinen, M. (2015) Contrast-Enhanced Ultrasonographic Detection and Dual-Phase Computed Tomographic Angiography in a 5-Year-Old Boxer with Pancreatic Insulinoma
—Case Report. Open Journal of Veterinary Medicine, 5, 175-180. doi: 10.4236/ojvm.2015.57024.

References

[1] Morris, J. and Dobson, J. (2001) Endocrine System. In: Morris, J. and Dobson, J., Eds., Small Animal Oncology, Blackwell Science, Oxford, 221-224.
http://uc-njavan.ir/MaXUpload/88/4-5-6/Small%20Animal%20Oncology.pdf

[2] Lunn, K.F. and Page, R.L. (2013) Tumors of the Endocrine System. In: Withrow, S.J., Vail, D.M. and Page, R.L., Eds., Withrow & MacEwen’s Small Animal Clinical Oncology, 5th Edition, Elsevier, Saunder, St. Louis, 519-521.
http://www.sciencedirect.com/science/article/pii/B9781437723625000256#
http://dx.doi.org/10.1016/b978-1-4377-2362-5.00025-6

[3] Hecht, S. and Henry, G. (2007) Sonographic Evaluation of the Normal and Abnormal Pancreas. Clinical Techniques in Small Animal Practice, 22, 115-121.
http://dx.doi.org/10.1053/j.ctsap.2007.05.005

[4] Vanderperren, K., Haers, H., Van der Vekens, E., Stock, E., Paepe, D., Daminet, S. and Saunders, J.H. (2013) Description of the Use of Contrast Enhanced Ultrasonography in Four Dogs with Pancreatic Tumours. Journal of Small Animal Practice, 55, 164-169.
http://dx.doi.org/10.1111/jsap.12153

[5] Robben, J., Pollak, Y., Kirpensteijn, J., Boroffka, S., van den Ingh, T., Teske, E. and Voorhout, G. (2005) Comparison of Ultrasonography, Computed Tomography, and Single-Photon Emission Computed Tomography for the Detection and Localization of Canine Insulinoma. Journal of Veterinary Internal Medicine, 19, 15-22.
http://dx.doi.org/10.1892/0891-6640(2005)19<15:COUCTA>2.0.CO;2

[6] Nakamura, K., Lim, S.-Y., Ochiai, K., Yamasaki, M., Ohta, H., Morishita, K., Takagi, S. and Takiguchi, M. (2014) Contrast-Enhanced Ultrasonographic Findings in Three Dogs with Pancreatic Insulinoma. Veterinary Radiology & Ultrasound, 56, 55-62.
http://dx.doi.org/10.1111/vru.12177

[7] Ardelean, M., Sirli, R., Sporea, I., Bota, S., Danila, M., Popescu, A., Timar, B., Buzas, R., Mazilu, O., Ardelean, O. and Lighezan, D. (2015) The Value of Contrast-Enhanced Ultrasound in the Characterization of Vascular Pattern of Solid Pancreatic Lesions. Medical Ultrasonography, 17, 16-21.

[8] D’Onofrio, M., Barbi, E., Dietrich, C.F., Kitano, M., Numata, K., Sofuni, A., Principe, F., Gallotti, A., Zamboni, A. and Mucelli, R.P. (2012) Pancreatic Multicenter Ultrasound Study (PAMUS). European Journal of Radiology, 81, 630-638.
http://dx.doi.org/10.1016/j.ejrad.2011.01.053

[9] Mai, W. and Cáceres, A.V. (2008) Dual-Phase Computed Tomographic Angiography in Three Dogs with Pancreatic Insulinoma. Veterinary Radiology & Ultrasound, 49, 141-148.
http://dx.doi.org/10.1111/j.1740-8261.2008.00340.x

[10] Iseri, T., Yamada, K., Chijiwa, K., Nishimura, R., Matsunaga, S., Fujiwara, R. and Sasaki, N. (2007) Dynamic Computed Tomography of the Pancreas in Normal Dogs and in a Dog with Pancreatic Insulinoma. Veterinary Radiology & Ultrasound, 48, 328-331.
http://dx.doi.org/10.1111/j.1740-8261.2007.00251.x

[11] Fidler, J., Fletcher, J., Reading, C., Andrews, J., Thompson, G., Grant, C. and Service, F. (2003) Preoperative Detection of Pancreatic Insulinomas on Multiphasic Helical CT. American Journal of Roentgenology, 181, 775-780.
http://dx.doi.org/10.2214/ajr.181.3.1810775

[12] Van Hoe, L., Gryspeerdt, S., Marchal, G., Baert, A.L. and Mertens, L. (1995) Helical CT for the Preoperative Localization of Islet Cell Tumors of the Pancreas: Value of Arterial and Parenchymal Phase Images. American Journal of Roentgenology, 165, 1437-1439.
http://dx.doi.org/10.2214/ajr.165.6.7484581