Target Transfusion Intra-Articular Therapy for Osteoarthritic Joints
Author(s)
Yulija M. Cherniakova
Affiliation(s)
Ministry of Health Republic of Belarus, Gomel State Medical University, Gomel, Belarus.
Ministry of Health Republic of Belarus, Gomel State Medical University, Gomel, Belarus.
ABSTRACT
The comparison of biochemical composition and biophysical properties of synovial fluid and blood serum leads to a conclusion about the pathogenetic expediency of using serum as a corrector of synovial medium of osteoarthritic joints. Serum modification was realized by preliminary prescription of a single-dose drug to the patient. Then, the patient’s blood was sampled in the period of its maximal saturation with the drug. Autoserum from such blood samples was injected thrice into the knee joints affected by osteoarthritis of the 2nd or 3rd stages. The value of treatment results after 4 - 6 months of described therapeutics shows a significantly better therapeutic effect in the experimental of patient’s group as compared with the control group. The effect is connected with pain diminishing, normalization of the tissue joint nutrition, suppression of the local inflammation, and improvement of cartilage lubrication.
The comparison of biochemical composition and biophysical properties of synovial fluid and blood serum leads to a conclusion about the pathogenetic expediency of using serum as a corrector of synovial medium of osteoarthritic joints. Serum modification was realized by preliminary prescription of a single-dose drug to the patient. Then, the patient’s blood was sampled in the period of its maximal saturation with the drug. Autoserum from such blood samples was injected thrice into the knee joints affected by osteoarthritis of the 2nd or 3rd stages. The value of treatment results after 4 - 6 months of described therapeutics shows a significantly better therapeutic effect in the experimental of patient’s group as compared with the control group. The effect is connected with pain diminishing, normalization of the tissue joint nutrition, suppression of the local inflammation, and improvement of cartilage lubrication.
Cite this paper
Cherniakova, Y. (2015) Target Transfusion Intra-Articular Therapy for Osteoarthritic Joints. International Journal of Clinical Medicine, 6, 500-505. doi: 10.4236/ijcm.2015.67067.
Cherniakova, Y. (2015) Target Transfusion Intra-Articular Therapy for Osteoarthritic Joints. International Journal of Clinical Medicine, 6, 500-505. doi: 10.4236/ijcm.2015.67067.
References
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http://dx.doi.org/10.1186/ar325 [2] Pavlova, V.N. (1980) Synovial Medium of Joints. Medicine, Moscow. [3] Pinchuk, L.S. and Chernyakova, Yu.M. (2009) A Methodology for Tribological Correction of Osteoarthritic Joints. Journal of Friction and Wear, 30, 172-175.
http://dx.doi.org/10.3103/S1068366609030040 [4] Beloenko, E.D., Cherniakova, Yu.M. and Pinchuk, L.S. (2007) Tribological Substantiation of a Chondropritective Method by Means of Blood Serum and Hyaluronates. Reports National Academy of Sciences of Belarus, 51, 72-75. [5] Belousov, Y.B., Moiseev, V.S. and Lepakhin, V.K. (1993) Clinical Pharmacology and Pharmacotherapy. Manual for Physicians. Universum, Moscow. [6] Laemmli, U.K. (1970) Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage. Nature, 227, 680-685.
http://dx.doi.org/10.1038/227680a0 [7] Pinchuk, L.S., Goldade, V.A., Sessler, G.M., et al. (2002) Electret-Thermal Analysis of Blood. Medical Engineering & Physics, 24, 361-364.
http://dx.doi.org/10.1016/S1350-4533(02)00029-2 [8] Pinchuk, L.S., Cherniakova, Yu.M. and Kadolich, Z.V. (2007) Method of Evaluation of Synovial Lubricity. BY Patent No. 9059. [9] Insall, J.N., Ravanat, C.S. and Aglietti, P. (1976) A Comparison of Four Models of Total Knee-Replacement Prosthesis. Journal of Bone and Joint Surgery, 58A, 754-765. [10] Bellami, N., Campbell, J., Robinson, V., et al. (2006) Viscosupplementation for the Treatment of Osteoarthritis of the Knee. Cochrane Database System Revue 2, CD005321.
http://dx.doi.org/10.1002/14651858.cd005321.pub2 [11] Pinchuk, L.S., Cherniakova, Yu.M. and Kadolich, Z.V. (2005) Research of Structural Changes of Synovial by Electret-Thermal Analysis Method. Bulletin Traumatology and Orthopedic Name N. N. Priorov, 3, 57-61. [12] Cherniakova, Yu.M., Kadolich, Z.V. and Pinchuk, L.S. (2004) Tribological Properties of Synovial as Criteria of Functional Insufficiency of Joint Lubrication Medium. Reports National Academy of Sciences of Belarus, 48, 75-79. [13] Cherniakova, Yu.M. (2009) Clinical Testing of Intra-Articular Chondroprotection Method by Blood Autoserum. Book of Abstracts of 16th European SICOT Trainees Meeting, Kolobrzeg, 7-9 May 2009, 5-6.
[1] Mort, J.S. and Billington, C.J. (2001) Articular Cartilage and Changes in Arthritis: Matrix Degradation. Arthritis Research, 3, 337-341.
http://dx.doi.org/10.1186/ar325 [2] Pavlova, V.N. (1980) Synovial Medium of Joints. Medicine, Moscow. [3] Pinchuk, L.S. and Chernyakova, Yu.M. (2009) A Methodology for Tribological Correction of Osteoarthritic Joints. Journal of Friction and Wear, 30, 172-175.
http://dx.doi.org/10.3103/S1068366609030040 [4] Beloenko, E.D., Cherniakova, Yu.M. and Pinchuk, L.S. (2007) Tribological Substantiation of a Chondropritective Method by Means of Blood Serum and Hyaluronates. Reports National Academy of Sciences of Belarus, 51, 72-75. [5] Belousov, Y.B., Moiseev, V.S. and Lepakhin, V.K. (1993) Clinical Pharmacology and Pharmacotherapy. Manual for Physicians. Universum, Moscow. [6] Laemmli, U.K. (1970) Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage. Nature, 227, 680-685.
http://dx.doi.org/10.1038/227680a0 [7] Pinchuk, L.S., Goldade, V.A., Sessler, G.M., et al. (2002) Electret-Thermal Analysis of Blood. Medical Engineering & Physics, 24, 361-364.
http://dx.doi.org/10.1016/S1350-4533(02)00029-2 [8] Pinchuk, L.S., Cherniakova, Yu.M. and Kadolich, Z.V. (2007) Method of Evaluation of Synovial Lubricity. BY Patent No. 9059. [9] Insall, J.N., Ravanat, C.S. and Aglietti, P. (1976) A Comparison of Four Models of Total Knee-Replacement Prosthesis. Journal of Bone and Joint Surgery, 58A, 754-765. [10] Bellami, N., Campbell, J., Robinson, V., et al. (2006) Viscosupplementation for the Treatment of Osteoarthritis of the Knee. Cochrane Database System Revue 2, CD005321.
http://dx.doi.org/10.1002/14651858.cd005321.pub2 [11] Pinchuk, L.S., Cherniakova, Yu.M. and Kadolich, Z.V. (2005) Research of Structural Changes of Synovial by Electret-Thermal Analysis Method. Bulletin Traumatology and Orthopedic Name N. N. Priorov, 3, 57-61. [12] Cherniakova, Yu.M., Kadolich, Z.V. and Pinchuk, L.S. (2004) Tribological Properties of Synovial as Criteria of Functional Insufficiency of Joint Lubrication Medium. Reports National Academy of Sciences of Belarus, 48, 75-79. [13] Cherniakova, Yu.M. (2009) Clinical Testing of Intra-Articular Chondroprotection Method by Blood Autoserum. Book of Abstracts of 16th European SICOT Trainees Meeting, Kolobrzeg, 7-9 May 2009, 5-6.