Moosa Patel^1*, Vinitha Philip¹, Tanvier Omar², Dianne Turton³, Geoff Candy⁴, Atul Lakha¹, Sugeshnee Pather²

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¹ Clinical Haematology Unit, Department of Medicine, Chris Hani Baragwanath Academic Hospital (CHBAH), Johannesburg, South Africa.
² Department of Anatomical Pathology, National Health Laboratory Services (NHLS), Johannesburg, South Africa.
³ Ampath Laboratories, Johannesburg (Previously, Department of Anatomical Pathology, NHLS), South Africa.
⁴ Department of Surgery, University of the Witwatersrand, Johannesburg, South Africa, and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
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Abstract: Human immunodeficiency virus (HIV) infection is endemic in South Africa. Non-Hodgkin lymphoma (NHL) occurs with increased frequency in HIV seropositive individuals. The increase in NHL has been more marked in the last decade, with HIV being the major contributor to this increase. More than 70% of the adult NHL patients at Chris Hani Baragwanath Academic Hospital (CHBAH), Soweto, Johannesburg, are HIV seropositive. In addition, HIV has impacted on the clinical presentation—being more aggressive and atypical. Histologically, HIV-NHL typically manifests as B-cell, high grade lymphomas, including diffuse large B-cell lymphoma (DLBCL); Burkitt lymphoma (BL); B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and BL and plasmablastic lymphoma. The latter two entities, which were previously rare or unknown, have gained prominence in the last decade, occurring primarily in HIV seropositive individuals. HIV-NHL, being associated with all these adverse prognostic factors results in a poorer overall survival.

Keywords: Human Immunodeficiency Virus (HIV), Non-Hodgkin Lymphoma (NHL), South Africa, High Grade, Adverse Prognostic Factors, Poorer Overall Survival

Cite this paper: Patel, M. , Philip, V. , Omar, T. , Turton, D. , Candy, G. , Lakha, A. and Pather, S. (2015) The Impact of Human Immunodeficiency Virus Infection (HIV) on Lymphoma in South Africa. Journal of Cancer Therapy, 6, 527-535. doi: 10.4236/jct.2015.66057.

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