WJCD  Vol.5 No.6 , June 2015
Hypertrophic Osteoathropathy without Pachyderma in a Nigerian: A Case Report
ABSTRACT
Hypertrophic osteoathropathy is characterized by triad of digital clubbing, periostosis, and pachyderma. We report the case of a young male Nigerian with asymptomatic idiopathic digital clubbing with neither skin changes nor periosteal reaction. He presented to our hospital with swelling of fingers and toes of about six years’ duration. All his fingers and toes were clubbed with drumstick appearance, no swelling or tenderness of the wrists, elbows, ankles or knees and no skin changes. The laboratory findings were normal. Primary hypertrophic osteoathropathy without pachydermia was entertained when neither skin changes nor periostosis were found. Although primary hypertrophic osteoathropathy without skin involvement is rare, effort should be made to search for secondary causes.

Cite this paper
Umar, A. , Adebayo, P. , A., A. , Okon, I. , Ikenna, U. (2015) Hypertrophic Osteoathropathy without Pachyderma in a Nigerian: A Case Report. World Journal of Cardiovascular Diseases, 5, 166-170. doi: 10.4236/wjcd.2015.56019.
References
[1]   Friedman, H.H. (2001) Clubbing. In: Friedman, M.H., Ed., Problem-Oriented Medical Diagnosis, 7th Edition, Lipponcpott Williams and Wilkins, Philadelphia, 277-278.

[2]   Hansen-Flaschen, J. and Nordberg, J. (1987) Clubbing and Hypertrophic Osteoarthropathy. Clinics in Chest Medicine, 8, 287-298.

[3]   Matucci-Cerinic, M., Lotti, T., Jajic, I., Pignone, A., Bussani, C. and Cagnoni, M. (1991) The Clinical Spectrum of Pachydermoperiostosis (Primary Hypertrophic Osteoarthropathy). Medicine, 70, 208-214.
http://dx.doi.org/10.1097/00005792-199105000-00005

[4]   Kerimovic-Morina, D.J. and Mladenovic, V. (1992) Primary Hypertrophic Osteoarthropathy in 32 Patients. Clinical and Experimental Rheumatology, 10, 51-56.

[5]   Prognostic. In: Jones, W.H., Ed., Hippocartes, Vol. II, Loeb Classic Library No. 148.

[6]   Vandemergel, X. and Renneboog, B. (2008) Prevalence, Aetiologies and Significance of Clubbing in a Department of General Internal Medicine. European Journal of Internal Medicine, 19, 325-329.
http://dx.doi.org/10.1016/j.ejim.2007.05.015

[7]   Macfarlane, J.T., Ibrahim, M. and Tor-Agbidye, S. (1979) The Importance of Finger Clubbing in Pulmonary Tuberculosis. Tubercle, 60, 45-48.
http://dx.doi.org/10.1016/0041-3879(79)90055-2

[8]   Kahaleh, M.B. (1992) The Role of Vascular Endothelium in Fibroblast Activation and Tissue Fibrosis, Particularly in Scleroderma (Systemic Sclerosis) and Pachydermoperiostosis (Primary Hypertrophic Steoarthropathy). Clinical and Experimental Rheumatology, 10, 45-48.

[9]   Matucci-Cerinic, M., Sacerdoti, L., Perrone, C., Carossino, A., Cagnoni, M.L., Jajic, I. and Lotti, T. (1992) Pachydermoperiostosis (Primary Hypertrophic Osteoarthropathy): In Vitro Evidence for Abnormal Fibroblast Proliferation. Clinical and Experimental Rheumatology, 10, 57-60.

[10]   Silveri, F., De Angelis, R., Argentati, F., Brecciaroli, D., Muti, S. and Cervini, C. (1996) Hypertrophic Osteoarthropathy: Endotheliumand Platelet Function. Clinical Rheumatology, 15, 435-439.
http://dx.doi.org/10.1007/BF02229639

[11]   Cosney, M.A., Cosney, J.R. and Lye, M. (1995) Carcinoma of the Bronchus. Thorax, 45, 545-547.

[12]   Brouwers, A.A., Vermeij-Keers, C., van Zoelen, E.J. and Gooren, L.J. (2004) Clubbed Fingers: The Claws We Lost? Medical Hypotheses, 62, 321-324.
http://dx.doi.org/10.1016/S0306-9877(03)00300-1

[13]   Atkinson, S. and Fox, S.B. (2004) Vascular Endothelial Growth Factor (VEGF)-A and Platelet-Derived Growth Factor (PDGF) Play a Central Role in the Pathogenesis of Digital Clubbing. Journal of Pathology, 203, 721-728.
http://dx.doi.org/10.1002/path.1565

 
 
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