Osama Almadhoun^1*, Teresa Rivera-Penera², Lauren Lipeski³

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¹ University of Kansas Medical Center, Kansas City, USA.
² Division of Pediatric Gastroenterology, St. Joseph’s Children Hospital, Paterson, USA.
³ Division of Pediatric Endocrinology, Upstate Medical Center, Golisano Children Hospital, Syracuse, USA.
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Abstract: Cholestatic jaundice and elevated liver enzymes are uncommon, but recognized, manifestations of neonatal thyrotoxicosis. Current guidelines for evaluation of cholestatic jaundice and reviews in Neonatology literature do not discuss hyperthyroidism in the differential diagnosis of cholestatic jaundice. We report two cases of neonatal thyrotoxicosis secondary to neonatal Graves’ disease that presented with cholestatic jaundice and elevated liver enzymes at birth. Early recognition of thyrotoxicosis as a cause of the hepatic disease in the neonate is crucial to prevent unnecessary diagnostic procedures and to initiate timely treatment.

Keywords: Neonate, Graves’ Disease, Thyrotoxicosis, Hyperthyroidism, Cholestasis, Hepatitis, Jaundice, Conjugated Hyperbilirubinemia

Cite this paper: Almadhoun, O. , Rivera-Penera, T. and Lipeski, L. (2015) Neonatal Graves’ Disease and Cholestatic Jaundice: Case Series and Review of the Literature. Open Journal of Pediatrics, 5, 179-184. doi: 10.4236/ojped.2015.52027.

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