IJCM  Vol.6 No.6 , June 2015
Serum Resistin Level and Polymorphonuclear Leukocytes Dysfunctions in Children on Regular Hemodialysis
Resistin is a secretory adipocytoine, which is expressed mainly in humans by inflammatory cells especially macrophages. Resistin serum levels are elevated in end-stage renal diseases of people having an increased risk of infections as a result of impaired polymorphonuclear leukocytes (PMNLs) functions. Objectives: To evaluate neutrophil functions (phagocytosis and oxidative burst) in children with end-stage renal disease (ESRD) on regular hemodialysis and to shed light on the contribution of resistin on neutrophil functions. Patients and Methods: The study included 40 children with ESRD on regular hemodialysis. Their ages ranged from 6 to 12 years, and they were selected from children attending the pediatric hemodialysis unit of AL-Zahraa Hospital, Al-Azher University during the period from October 2012 to December 2013. Another group of 40 apparently healthy children with matched age and sex with the patient group served as a control. Serum resistin, phagocytic index and nitro blue tetrazolium test (NBT%) were assessed in both groups. Results: There was a statistically more significant increase in resistin serum levels in cases than in controls; it was (3.25 ± 0.86 ng/ml) and (0.25 ± 0.16 ng/ml) respectively (P < 0.01). On the other hand there was a statistically more significant decrease in neutrophil phagocytic index in cases than in controls; it was (2.57 ± 1.34) and (3.55 ± 0.74) respectively (P < 0.01). Also it showed a statistically more significant decrease in NBT% in cases than in controls; it was (47.98 ± 16.38%) and (61.45 ± 13.17%) respectively (P < 0.01). We found negative correlation between resistin serum level with phagocytic index and NBT%, while we found positive correlation between resistin serum level and hemodialysis duration. Conclusion: High resistin serum level in children with ESRD decreases phagocyte function and oxidative burst of PMNLs, and this is enhanced by the longer duration of hemodialysis.

Cite this paper
Zein, M. , Abdel-Salam, M. , Abdel-Aziz, I. and Mohamed, N. (2015) Serum Resistin Level and Polymorphonuclear Leukocytes Dysfunctions in Children on Regular Hemodialysis. International Journal of Clinical Medicine, 6, 423-430. doi: 10.4236/ijcm.2015.66055.
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