OJRD  Vol.5 No.3 , August 2015
Multidetector Computed Tomography Evaluation of Mediastinal Lesions with Histopathological Diagnosis
ABSTRACT
The evaluation of mediastinal abnormalities is a challenging radiographical problem. Cross-sectional imaging of the mediastinum by computed tomography now demonstrates precise anatomic details and is the imaging modality of choice for most mediastinal lesions. The following study was undertaken with the objectives of determining the mediastinal lesions affecting the mediastinum and to correlate the computed tomography findings with the histopathology reports. In this study, 50 patients clinically suspected with mediastinal mass lesions or who had chest radio-graph with a suspicious mediastinal lesion were evaluated from October 2013 to September 2014. In our study, we used varying computed tomography features of each mediastinal pathology types to predict a histological diagnosis of mediastinal lesions. Most of the lesions could be predicted with good sensitivity, specificity and diagnostic accuracy.

Cite this paper
Arumugam, V. , Nazir, H. and Rajasekar, K. (2015) Multidetector Computed Tomography Evaluation of Mediastinal Lesions with Histopathological Diagnosis. Open Journal of Respiratory Diseases, 5, 55-62. doi: 10.4236/ojrd.2015.53006.
References
[1]   Benjamin, S.P., McCormack, L.J., Effler, D.B. and Groves, L.K. (1972) Primary Tumors of the Mediastinum. Chest, 62, 297-303.
http://dx.doi.org/10.1378/chest.62.3.297

[2]   Rebner, M., Gross, B.H., Robertson, J.M., Pennes, D.R., Spizarny, D.L. and Glazer, G.M. (1987) CT Evaluation of Mediastinal Masses. Computerized Radiology, 11, 103-110.
http://dx.doi.org/10.1016/0730-4862(87)90033-3

[3]   Strollo, D.C., Rosado-de-Christenson, M.L. and Jett, J.R. (1997) Primary Mediastinal Tumors. Part 1. Tumors of the Anterior Mediastinum. Chest, 112, 511-522.
http://dx.doi.org/10.1378/chest.112.2.511

[4]   Takeda, S., Miyoshi, S., Akashi, A., Ohta, M., Minami, M., Okumura, M., Masaoka, A. and Matsuda, H. (2003) Clinical Spectrum of Primary Mediastinal Tumors: A Comparison of Adult and Pediatric Populations at a Single Japanese Institution. Journal of Surgical Oncology, 83, 24-30.
http://dx.doi.org/10.1002/jso.10231

[5]   Davis, R.D., et al. (1987) Primary Cysts and Neoplasms of the Mediastinum: Recent Changes in Clinical Presentations, Methods of Diagnosis, Management and Results. Annals of Thoracic Surgery, 44, 229-237.
http://dx.doi.org/10.1016/S0003-4975(10)62059-0

[6]   Cohen, A.J., Thompson, L.N., Edwards, F.H., et al. (1991) Primary Cysts and Tumors of the Mediastinum. Annals of Thoracic Surgery, 51, 378-386.
http://dx.doi.org/10.1016/0003-4975(91)90848-K

[7]   Chen, J., Weisbrod, G.L. and Herman, S.J. (1988) Computed Tomography and Pathologic Correlations of Thymic Lesion. Journal of Thoracic Imaging, 3, 61-65.
http://dx.doi.org/10.1097/00005382-198801000-00010

[8]   Naidich, D.P., Webb, W.R., Muller, N.L., Zerhouni, E.A. and Seigelmann, S.S. (1999) Mediastinum. Chapter 2. In: Naidich, D.P., Muller, N.L., Zerhouni, E.A., Webb, W.R. and Krinsky, G.A., Eds., Computed Tomography and Magnetic Resonance of the Thorax, 3rd Edition, Lippincott Williams and Wilkins, Philadelphia, 38-160.

[9]   Lara Jr., P.N. (2000) Malignantthymoma: Current Status and Future Directions. Cancer Treatment Reviews, 26, 127-131.
http://dx.doi.org/10.1053/ctrv.1999.0159

[10]   de Kraker, M., et al. (2005) CT and Myasthenia Gravis: Correlation between Mediastinal Imaging and Histopathological Findings. Interactive CardioVasc Thoracic Surgery, 4, 267-271.
http://dx.doi.org/10.1510/icvts.2004.097246

[11]   Wychulis, A.R., Payne, W.S., Clagett, O.T., et al. (1971) Surgical Treatment of Mediastinal Tumors: A 40 Year Experience. Journal of Thoracic and Cardiovascular Surgery, 62, 379-392.

[12]   Totanarungroj, K., Watcharaporn, C. and Muangman, N. (2010) Helpful CT Findings for Giving Specific Diagnosis of Anterior Mediastinal Tumors. Journal of the Medical Association of Thailand, 93, 489-496.

[13]   Tian, L., Liu, L.Z., Cui, C.Y., Zhang, W.D. and Kuang, Y.L. (2012) CT Findings of Primary Non-Teratomatous Germ Cell Tumors of the Mediastinum—A Report of 15 Cases. European Journal of Radiology, 81, 1057-1061.
http://dx.doi.org/10.1016/j.ejrad.2011.02.005

[14]   Binder, R., Pugatch, R., Faling, L., Kanter, R. and Sawin, C. (1980) Diagnosis of Posterior Mediastinal Goiter by Computed Tomography. Journal of Computer Assisted Tomography, 4, 550-552.
http://dx.doi.org/10.1097/00004728-198008000-00031

[15]   Kim, H.C., Han, M.H., Kim, K.H., Jae, H.J., Lee, S.H., Kim, S.S., Kim, K.H. and Chang, K.H. (2003) Primary Thyroid Lymphoma: CT Findings. European Journal of Radiology, 46, 233-239.
http://dx.doi.org/10.1016/S0720-048X(02)00134-1

[16]   Rankin, S. (1998) Oesophageal Cancer. In: Husband, J.E.S. and Reznek, R.H., Eds., Imaging in Oncology, Isis Medical Media, Oxford, 93-110.

[17]   Megibow, A.J., Balthazar, E.J., Hulnick, D.H., et al. (1985) CT Evaluation of Gastrointestinal Leiomyomas and Leiomyosarcomas. AJR, 144, 727-731.
http://dx.doi.org/10.2214/ajr.144.4.727

[18]   Takasugi, J.E., Godwin, J.D., Marglin, S.I. and Petersdorf, S.H. (1996) Intrathoracic Granulocytic Sarcomas. Journal of Thoracic Imaging, 11, 223-230.
http://dx.doi.org/10.1097/00005382-199601130-00006

 
 
Top