A New Therapy for Human Endometriosis: The Therapeutic Value of Leukotriene Receptor Antagonist for Endometriosis
Affiliation(s)
1 Department of Pathology, Tochigi Institute of Clinical Pathology, Tochigi, Japan. 2 Department of Obstetrics and Gynecology, Japan Red Cross Hospital Omori, Tokyo, Japan.
1 Department of Pathology, Tochigi Institute of Clinical Pathology, Tochigi, Japan. 2 Department of Obstetrics and Gynecology, Japan Red Cross Hospital Omori, Tokyo, Japan.
ABSTRACT
Some drugs that regulate estrogen are currently used as therapy for endometriosis. However, these medical treatments have significant side effects and patients who hope to become pregnant cannot overcome infertility. To compare morphological alterations and clinical symptoms, revised American Fertility Society (r-AFS) scores were compared between patients with and without leukotriene receptor antagonist (LTR-A) treatment. LTR-A-treated cases showed significantly decreased r-AFS score. Furthermore, a significant correlation was seen between r-AFS score and LTR-A treatment period. In treated cases, clinical symptoms decreased and some patients achieved pregnancy. Morphologically, lesions in LTR-A-treated cases showed apoptotic fibroblasts and degeneration of collagen fibers. Our findings revealed that LTR-As had significant therapeutic value for the treatment of human endometriosis. Anti-LT therapy appears efficacious not only in the treatment of clinical symptoms and lesions, but also in improving fertility.
Some drugs that regulate estrogen are currently used as therapy for endometriosis. However, these medical treatments have significant side effects and patients who hope to become pregnant cannot overcome infertility. To compare morphological alterations and clinical symptoms, revised American Fertility Society (r-AFS) scores were compared between patients with and without leukotriene receptor antagonist (LTR-A) treatment. LTR-A-treated cases showed significantly decreased r-AFS score. Furthermore, a significant correlation was seen between r-AFS score and LTR-A treatment period. In treated cases, clinical symptoms decreased and some patients achieved pregnancy. Morphologically, lesions in LTR-A-treated cases showed apoptotic fibroblasts and degeneration of collagen fibers. Our findings revealed that LTR-As had significant therapeutic value for the treatment of human endometriosis. Anti-LT therapy appears efficacious not only in the treatment of clinical symptoms and lesions, but also in improving fertility.
Cite this paper
Sugamata, M. , Ihara, T. and Uchiide, I. (2015) A New Therapy for Human Endometriosis: The Therapeutic Value of Leukotriene Receptor Antagonist for Endometriosis. Open Journal of Obstetrics and Gynecology, 5, 313-318. doi: 10.4236/ojog.2015.56045.
Sugamata, M. , Ihara, T. and Uchiide, I. (2015) A New Therapy for Human Endometriosis: The Therapeutic Value of Leukotriene Receptor Antagonist for Endometriosis. Open Journal of Obstetrics and Gynecology, 5, 313-318. doi: 10.4236/ojog.2015.56045.
References
[1] Houston, D.E., Noller, K.L., Melton III, L.J. and Selwyn, B.J. (1988) The Epidemiology of Pelvic Endometriosis. Clinical Obstetrics and Gynecology, 31, 787-800.
http://dx.doi.org/10.1097/00003081-198812000-00005 [2] Dmownski, W.P., Braum, D. and Gebel, H.M. (1990) Endometriosis: Genetics and Immunologic Aspects. Current Concepts in Endometriosis. Alan R Liss, New York, 99-122. [3] Sugamata, M., Ihara, T. and Uchiide, I. (2005) Increase of Activated Mast Cells in Human Endometriosis. American Journal of Reproductive Immunology, 53, 120-125.
http://dx.doi.org/10.1111/j.1600-0897.2005.00254.x [4] Uchiide, I., Ihara, T. and Sugamata, M. (2002) Pathological Evaluation of Rat Endometriosis Model. Fertility and Sterility, 78, 782-786.
http://dx.doi.org/10.1016/S0015-0282(02)03327-7 [5] Ihara, T., Uchiide, I. and Sugamata, M. (2004) Light and Electron Microscopic Evaluation of Antileukotriene Therapy for Experimental Rat Endometriosis. Fertility and Sterility, 81, 819-823.
http://dx.doi.org/10.1016/j.fertnstert.2003.08.029 [6] The American Fertility Society (1985) Revised American Fertility Society Classification of Endometriosis. Fertility and Sterility, 43, 351-352. [7] Fawcett, D.W. and Jensh, R.P. (1997) Bloom & Fawcett: Concise Histology. Chapman & Hall, New York, 51-52. [8] Ihara, T., Yamamoto, T., Sugamata, M., Okumura, H. and Ueno, Y. (1998) The Process of Ultrastructural Change from Nuclei to Apoptotic Body. Virchows Arch, 433, 443-447.
http://dx.doi.org/10.1007/s004280050272 [9] Benebetto, C. (1989) Eicosanoids in Primary Dysmenorrheal, Endometriosis and Menstrual Migraine. Gynecological Endocrinology, 3, 71-94.
http://dx.doi.org/10.3109/09513598909152454 [10] Yamaguchi, M. and Mori, N. (1990) Prostaglandin and Leukotriene Concentration of the Peritoneal Fluid of Endometriosis and Other Gynecologic Disorders in Secretory Phase. Prostaglandins, Leukotrienes and Essential Fatty Acids, 39, 43-45.
http://dx.doi.org/10.1016/0952-3278(90)90170-P [11] Karim, S.M. and Hillier, K. (1979) Prostaglandins in the Control of Animal and Human Reproduction. British Medical Bulletin, 35, 173-180. [12] Fakih, H., Baggett, B., Holtz, G., Tsang, K.Y., Lee, J.C. and Williamson, H.O. (1987) Interleukin-1: A Possible Role in the Infertility Associated with Endometriosis. Fertility and Sterility, 47, 213-217. [13] Ota, H., Igarashi, S., Hatazawa, J. and Taka, T. (1999) Immunohistochemical Assessmeny of Superoxide Dismutase Expression in the Endometrium in Endometriosis and Adenomyosis. Fertility and Sterility, 72, 129-134.
http://dx.doi.org/10.1016/S0015-0282(99)00152-1
[1] Houston, D.E., Noller, K.L., Melton III, L.J. and Selwyn, B.J. (1988) The Epidemiology of Pelvic Endometriosis. Clinical Obstetrics and Gynecology, 31, 787-800.
http://dx.doi.org/10.1097/00003081-198812000-00005 [2] Dmownski, W.P., Braum, D. and Gebel, H.M. (1990) Endometriosis: Genetics and Immunologic Aspects. Current Concepts in Endometriosis. Alan R Liss, New York, 99-122. [3] Sugamata, M., Ihara, T. and Uchiide, I. (2005) Increase of Activated Mast Cells in Human Endometriosis. American Journal of Reproductive Immunology, 53, 120-125.
http://dx.doi.org/10.1111/j.1600-0897.2005.00254.x [4] Uchiide, I., Ihara, T. and Sugamata, M. (2002) Pathological Evaluation of Rat Endometriosis Model. Fertility and Sterility, 78, 782-786.
http://dx.doi.org/10.1016/S0015-0282(02)03327-7 [5] Ihara, T., Uchiide, I. and Sugamata, M. (2004) Light and Electron Microscopic Evaluation of Antileukotriene Therapy for Experimental Rat Endometriosis. Fertility and Sterility, 81, 819-823.
http://dx.doi.org/10.1016/j.fertnstert.2003.08.029 [6] The American Fertility Society (1985) Revised American Fertility Society Classification of Endometriosis. Fertility and Sterility, 43, 351-352. [7] Fawcett, D.W. and Jensh, R.P. (1997) Bloom & Fawcett: Concise Histology. Chapman & Hall, New York, 51-52. [8] Ihara, T., Yamamoto, T., Sugamata, M., Okumura, H. and Ueno, Y. (1998) The Process of Ultrastructural Change from Nuclei to Apoptotic Body. Virchows Arch, 433, 443-447.
http://dx.doi.org/10.1007/s004280050272 [9] Benebetto, C. (1989) Eicosanoids in Primary Dysmenorrheal, Endometriosis and Menstrual Migraine. Gynecological Endocrinology, 3, 71-94.
http://dx.doi.org/10.3109/09513598909152454 [10] Yamaguchi, M. and Mori, N. (1990) Prostaglandin and Leukotriene Concentration of the Peritoneal Fluid of Endometriosis and Other Gynecologic Disorders in Secretory Phase. Prostaglandins, Leukotrienes and Essential Fatty Acids, 39, 43-45.
http://dx.doi.org/10.1016/0952-3278(90)90170-P [11] Karim, S.M. and Hillier, K. (1979) Prostaglandins in the Control of Animal and Human Reproduction. British Medical Bulletin, 35, 173-180. [12] Fakih, H., Baggett, B., Holtz, G., Tsang, K.Y., Lee, J.C. and Williamson, H.O. (1987) Interleukin-1: A Possible Role in the Infertility Associated with Endometriosis. Fertility and Sterility, 47, 213-217. [13] Ota, H., Igarashi, S., Hatazawa, J. and Taka, T. (1999) Immunohistochemical Assessmeny of Superoxide Dismutase Expression in the Endometrium in Endometriosis and Adenomyosis. Fertility and Sterility, 72, 129-134.
http://dx.doi.org/10.1016/S0015-0282(99)00152-1