OJCD  Vol.5 No.2 , June 2015
Primary Lymphoma of the Larynx: A Case Report and Literature Review
Abstract: Background: Primary non-hodgkin lymphoma of the larynx is a rare entity accounting for 1% of laryngeal tumors. Fewer than 100 cases have been reported in the literature. Case presentation: A 52-year-old man, presented with a two-month history of dysphonia. Nasofibroscopy showed left submucosal bulging of the laryngeal supraglottic floor. Cervical computed tomography showed extensive left supraglottic mass, with partial lysis of the thyroid cartilage. Direct laryngoscopy showed left submucosal bulging of the supraglottic floor. Transmucosal biopsies were performed. Histological study concluded to the presence of a diffuse large-cell B lymphoma. The patient was treated with chemotherapy followed by external radiotherapy. Evolution was favourable. Conclusion: Although primary laryngeal non-hodgkin lymphoma is rare, it should be considered in the differential diagnosis of a mass in the neck region, especially in the supraglottic area. Direct laryngoscopy with biopsy makes the diagnosis. Treatment and prognosis depend on the stage and the grade of the lymphoma.
Cite this paper: Khamassi, K. , Mahfoudhi, M. , Jaafoura, H. , Ouertani, K. , Kaabachi, W. , Bougacha, L. , Lahiani, R. and Salah, M. (2015) Primary Lymphoma of the Larynx: A Case Report and Literature Review. Open Journal of Clinical Diagnostics, 5, 81-85. doi: 10.4236/ojcd.2015.52015.

[1]   Ezzat, A.A., Ibrahim, E.M., El Weshi, A.N., Khafaga, Y.M., AlJurf, M., Martin, J.M., et al. (2001) Localized Non-Hodgkin’s Lymphoma of Waldeyer’s Ring: Clinical Features, Management, and Prognosis of 130 Adult Patients. Head Neck, 23, 547-558.

[2]   Pak, M.V., Woo, J.K.S. and van Hasselt, C.A. (1999) T-Cell Non-Hodgkin’s Lymphoma of the Larynx and Hypopharynx. Otolaryngology—Head and Neck Surgery, 121, 335-336.

[3]   Zapparoli, M., Trolese, A.R., Remo, A., Sina, S., Bonetti, A. and Micheletto, C. (2014) Subglotic Malt-Lymphoma of the Larynx: An Unusual Presentation of Chronic Cough. International Journal of Immunopathology and Pharmacology, 27, 461-465.

[4]   King, A.D., Yuen, E.H., Lei, K.I., Ahuja, A.T. and Van Hasselt, A. (2004) Non-Hodgkin Lymphoma of the Larynx: CT and MR Imaging Findings. AJNR American Journal of Neuroradiology, 25, 12-15.

[5]   Ansell, S.M., Habermann, T.M., Hoyer, J.D., Strickler, J.G., Chen, M.G. and McDonald, T.J. (1997) Primary Laryngeal Lymphoma. The Laryngoscope, 107, 1502-1506.

[6]   Azzopardi, C.P., Degaetano, J., Betts, A., Farrugia, E., Magri, C., Refalo, N., et al. (2014) Laryngeal Lymphoma: The High and Low Grades of Rare Lymphoma Involvement Sites. Case Reports in Medicine, 2014, Article ID: 284643.

[7]   Yilmaz, M., Ibrahimov, M., Mamanov, M., Rasidov, R. and Oktem, F. (2012) Primary Marginal Zone B-Cell Lymphoma of the Larynx. Journal of Craniofacial Surgery, 23, e1-e2.

[8]   Salazar Guilarte, J.X., Sancho Mestre, M. and Gras Albert, J.R. (2012) Laryngeal Manifestation of B-Cell Non-Hodgkin Lymphoma. Acta Otorrinolaringológica Española, 63, 485-487.

[9]   Desai, S.C., Allen, C., Chernock, R. and Haughey, B. (2011) Pathology Quiz Case 1. Primary Diffuse Large B-Cell Lymphoma of the Larynx. Archives of Otolaryngology—Head & Neck surgery, 137, 526,528.

[10]   Markou, K., Goudakos, J., Constantinidis, J., Kostopoulos, I., Vital, V. and Nikolaou, A. (2010) Primary Laryngeal Lymphoma: Report of 3 Cases and Review of the Literature. Head & Neck, 32, 541-549.

[11]   Zhao, K., Luo, Y.Z., Zhou, S.H., Dai, B.L., Luo, X.M., Yan, S.X., et al. (2012) 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Findings in Mucosa-Associated Lymphoid Tissue Lymphoma of the Larynx: A Case Report and Literature Review. The Journal of International Medical Research, 40, 1192-1206.

[12]   Stephenson, K., Peer, S., Govender, D. and Fagan, J.J. (2013) Plasmablastic Lymphoma of the Larynx: Report of Two Cases. The Journal of Laryngology & Otology, 127, 96-99.

[13]   Elmazghi, A., Elkacemi, H., Lalya, I., Zaidi, H., Harmouch, A., Kanouni, L., et al. (2011) Primary Malignant Non-Hodgkin Lymphoma of the Larynx: Report of a Case. Pan African Medical Journal, 9, 17.

[14]   Roca, B., Vidal-Tegedor, B. and Moya, M. (2005) Primary Non-Hodgkin Lymphoma of the Larynx. Southern Medical Journal, 98, 388-389.

[15]   Word, R., Urquhart, A.C. and Ejercito, V.S. (2006) Primary Laryngeal Lymphoma: Case Report. Ear Nose & Throat Journal, 85, 109-111.

[16]   Paleri, V., Stafford, F.W. and Sammut, M.S. (2005) Laser Debulking in Malignant Upper Airway Obstruction. Head & Neck, 27, 296-301.

[17]   Cavalot, A.L., Preti, G., Vione, N., Nazionale, G., Palonta, F. and Fadda, G.L. (2001) Isolated Primary Non-Hodgkin’s Malignant Lymphoma of the Larynx. The Journal of Laryngology & Otology, 115, 324-326.