OJMC  Vol.5 No.2 , June 2015
Synthesis and Bioactivity of Natural Occurring Petasin-Like Derivatives as Antitumor Agents
Abstract: Petasin is a potential antitumor against human neuroblastoma cell SK-N-SH by inhibiting the ERK1/2 phosphorylation. In view of its great activity and new antiproliferative mechanisms, a series of petasin derivatives were designed and synthesized, which showed great antiproliferative activity. Among them compounds 1h and 1f were more effective against SK-N-SH cells than petasin with the IC50 values of 0.87 and 2.63 μM, respectively.
Cite this paper: Shi, X. , Zhang, S. , Wang, J. , Li, T. , Liu, J. , Hou, Y. , Liu, L. , Fu, D. , Xu, H. , Hongmin, H. and Zhang, Y. (2015) Synthesis and Bioactivity of Natural Occurring Petasin-Like Derivatives as Antitumor Agents. Open Journal of Medicinal Chemistry, 5, 23-31. doi: 10.4236/ojmc.2015.52003.

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