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 OJU  Vol.5 No.6 , June 2015
The Association between Autosomal Dominant Polycystic Kidney Disease and Renal Cell Carcinoma
Abstract: Objectives: The relationship between autosomal dominant polycystic kidney disease (ADPKD) and renal cell carcinoma (RCC) is investigated to determine a link that would guide management due to elevated RCC risk. Current literature is inconclusive on this topic. Methods: This study is a retrospective chart review of patients having undergone nephrectomy. Those with pathology and history consistent with ADPKD were reviewed for presence of RCC. Results: The review at this institution revealed RCC in 18% of ADPKD patients who underwent nephrectomy. These rates are significantly higher than those found in the general population, and even greater than those would be expected in patients suffering end-stage renal disease (ESRD). Conclusions: Due to the increased prevalence of RCC in ADPKD, clinicians managing patients with ADPKD should maintain a high index of suspicion. Our data suggest a link between ADPKD and RCC, most likely at the genetic level. In light of this, we feel that further genetic research is needed to potentially discover the link between these two disease processes.
Cite this paper: C. Hansen, C. , Derrick, M. , Warriach, I. , Cammack, J. , Cammack, J. and Riese, W. (2015) The Association between Autosomal Dominant Polycystic Kidney Disease and Renal Cell Carcinoma. Open Journal of Urology, 5, 84-90. doi: 10.4236/oju.2015.56013.
References

[1]   Torres, V.E. and Harris, P.C. (2009) Autosomal Dominant Polycystic Kidney Disease: The Last 3 Years. Kidney International, 76, 149-168. http://dx.doi.org/10.1038/ki.2009.128

[2]   Torres, V.E., Harris, P.C. and Pirson, Y. (2007) Autosomal Dominant Polycystic Kidney Disease. The Lancet, 369, 1287-1301. http://dx.doi.org/10.1016/S0140-6736(07)60601-1

[3]   Harris, P.C. and Torres, V.E. (2009) Polycystic Kidney Disease. Annual Review of Medicine, 60, 321-337. http://dx.doi.org/10.1146/annurev.med.60.101707.125712

[4]   Howlader, N., Noone, A.M., Krapcho, M., et al. (2012) SEER Cancer Statistics Review, 1975-2011. National Cancer Institute, Bethesda. http://seercancer-gov/csr/1975_2009_pops09/

[5]   Tan, M., Wettersten, H.I., Chu, K., et al. (2014) Novel Inhibitors of Nuclear Transport Cause Cell Cycle Arrest and Decrease Cyst Growth in ADPKD Associated with Decreased cdk4 Levels. The American Journal of Physiology— Renal Physiology, 307, F1179-F1186.

[6]   Hajj, P., Ferlicot, S., Massoud, W., et al. (2010) Prevalence of Renal Cell Carcinoma in Patients with Autosomal Dominant Polycystic Kidney Disease and Chronic Renal Failure. Urology, 74, 631-634.

[7]   Lane, W., Lacefield, E., Tran, R. and de Riese, W. (2011) The Clinical Association of Autosomal Dominant Polycystic Kidney Disease and Renal Cell Carcinoma. Open Journal of Urology, 1, 11-14.

[8]   Lopez-Beltran, A., Scarpelli, M., Montironi, R. and Kirkali, Z. (2004) WHO Classification of the Renal Tumors of the Adults. European Urology, 49, 798-805.
http://dx.doi.org/10.1016/j.eururo.2005.11.035

[9]   Torres, V.E., Harris, P.C. and Pirson, Y. (2007) Autosomal Dominant Polycystic Kidney Disease. The Lancet, 369, 1287-1301. http://dx.doi.org/10.1016/S0140-6736(07)60601-1

[10]   Walters, W. and Braasch, W.F. (1934) Surgical Aspects of Polycystic Kidney. SurgGynecolObstet, 647-650.

[11]   Konosu-Fukaya, S., Nakamura, Y., Fujishima, F., Kasajima, A., Takahashi, Y., et al. (2013) Bilateral Papillary Renal Cell Carcinoma and Angiomyolipoma in the Patients with Autosomal Dominant Polycystic Kidney Disease: Case Report of Two Cases and Literature Review. Polish Journal of Pathology, 64, 303-307.

[12]   Na, K.Y., Kim, H.S., Park, Y.K., Chang, S.G. and Kim, Y.W. (2012) Multifocal Renal Cell Carcinoma of Different Histological Subtypes in Autosomal Dominant Polycystic Kidney Disease. Korean Journal of Pathology, 46, 382-386.http://dx.doi.org/10.4132/KoreanJPathol.2012.46.4.382

[13]   Truong, L.D., Choi, Y.J., Shen, S.S., Ayala, G., Amato, R. and Krishnan, B. (2003) Renal Cystic Neoplasms and Renal Neoplasms Associated with Cystic Renal Diseases: Pathogenetic and Molecular Links. Advances in Anatomic Pathology, 10, 135-59.
http://dx.doi.org/10.1097/00125480-200305000-00003

[14]   Vogelzang, N.J. and Stadler, W.M. (1998) Kidney Cancer. Lancet, 352, 1691-1696.

[15]   Keith, D.S., Torres, V.E., King, B.F., Zincki, H. and Farrow, G.M. (1994) Renal Cell Carcinoma in Autosomal Dominant Polycystic Kidney Disease. Journal of the American Society of Nephrology, 4, 1661-1669.

[16]   Einollahi, B. (2012) Are Acquired Cystic Kidney Disease and Autosomal Dominant Polycystic Kidney Disease Risk Factors for Renal Cell Carcinoma in Kidney Transplant Patients? Journal of Neuropathology, 1, 65-68.http://dx.doi.org/10.5812/nephropathol.7447

[17]   Bonsib, S.M. (2009) Renal Cystic Diseases and Renal Neoplasms: A Mini-Review. Clinical Journal of the American Society of Nephrology, 4, 1998-2007. http://dx.doi.org/10.2215/CJN.02020309

[18]   Jilg, C.A., Drendel, V., Bacher, J., Pisarski, P., Neeff, H., et al. (2013) Autosomal Dominant Polycystic Kidney Disease: Prevalence of Renal Neoplasias in Surgical Kidney Specimens. Nephron Clinical Practice, 123, 13-21.http://dx.doi.org/10.1159/000351049

[19]   Orskov, B., Sorensen, V.R., Feldt-Rasmussen, B. and Strandgaard, S. (2012) Changes in Causes of Death and Risk of Cancer in Danish Patients with Autosomal Dominant Polycystic Kidney Disease and End-Stage Renal Disease. Nephrology Dialysis Transplantation, 27, 1607-1613.
http://dx.doi.org/10.1093/ndt/gfr467

[20]   Kane, C.J., Mallin, K., Ritchey, J., Cooperberg, M.R. and Carroll, P.R. (2008) Renal Cell Cancerstage Migration: Ana- lysis of the National Cancer Data Base. Cancer, 113, 78-83.
http://dx.doi.org/10.1002/cncr.23518

[21]   Patard, J.J., Leray, E., Rioux-Leclercq, N., Cindolo, L., Ficarra, V., et al. (2005) Prognostic Value of Histologic Subtypes in Renal Cell Carcinoma: A Multicenter Experience. Journal of Clinical Oncology, 23, 2763-2771.http://dx.doi.org/10.1200/JCO.2005.07.055

[22]   Hateboer, N., v Dijk, M.A., Bogdanova, N., Coto, E., Saggar-Malik, A.K., et al. (1999) Comparison of Phenotypes of Polycystic Kidney Disease Types 1 and 2. European PKD1-PKD2 Study Group. Lancet, 353, 103-107.http://dx.doi.org/10.1016/S0140-6736(98)03495-3

[23]   Ito, K., Asano, T., Tominaga, S., Yoshii, H., Sawazaki, H. and Asano, T. (2014) Erythropoietin Production in Renal Cell Carcinoma and Renal Cysts in Autosomal Dominant Polycystic Kidney Disease in a Chronic Dialysis Patient with Polycythemia: A Casereport. Oncology Letters, 8, 2032-2036.

[24]   Misumi, T., Ide, K., Onoe, T., Banshodani, M., Tazawa, H., et al. (2012) Incidental Renal Cell Carcinoma Presenting in a Renal Transplant Recipient with Autosomal Dominant Polycystic Kidney Disease: A Case Report. Journal of Medical Case Reports, 6, 154.

[25]   Zeile, M., Andreou, D., Poellinger, A., Tunn, P.U. and Dudeck, O. (2011) Identification of the Primary Tumour with the Help of Diffusion-Weighted MRI in a Patient with Autosomal Dominant Polycystic Kidney Disease and Metastatic Renal Cell Carcinoma. British Journal of Radiology, 84, e142-5.
http://dx.doi.org/10.1259/bjr/32867810

[26]   Chang, M.Y., Chen, Y.M., Chen, Y.C., Tian, Y.C., Fang, J.T. and Yang, C.W. (2009) Concurrent Renal Cell Carcinoma and Central Nervous System Lymphoma in a Patient with Autosomal Dominant Polycystic Kidney Disease. Medical Principles and Practice, 18, 486-489.
http://dx.doi.org/10.1159/000235900

[27]   Nishimura, H., Ubara, Y., Nakamura, M., Nakanishi, S., Sawa, N., et al. (2009) Renal Cell Carcinoma in Autosomal Dominant Polycystic Kidney Disease. American Journal of Kidney Diseases, 54, 165-168.
http://dx.doi.org/10.1053/j.ajkd.2009.01.270

[28]   Chang, Y.L., Chung, H.J. and Chen, K.K. (2007) Bilateral Renal Cell Carcinoma in a Patient with Autosomal Dominant Polycystic Kidney Disease. Journal of the Chinese Medical Association, 70, 403-405.http://dx.doi.org/10.1016/S1726-4901(08)70029-7

[29]   Hama, Y., Kaji, T., Ito, K., Hayakawa, M., Tobe, M. and Kosuda, S. (2005) Erythropoietin-Producing Renal Cell Carcinoma Arising from Autosomal Dominant Polycystic Kidney Disease. British Journal of Radiology, 78, 269-271.PubMed PMID: 15730996. http://dx.doi.org/10.1259/bjr/28214940

[30]   Lang, E.K. and Davis, R. (2005) Autosomal Dominant Polycystic Disease with Renal Cell Carcinoma. Journal of Urology, 173, 987. http://dx.doi.org/10.1097/01.ju.0000153739.20733.6a

 
 
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