OJPed  Vol.5 No.2 , June 2015
Correlation between Vitamin C Deficiency and Hydroxyproline Amino Acid in Young Children of Northern Part in Palestine
ABSTRACT
Vitamin C is a water soluble vitamin found in many natural sources, citric fruits, vegetables, particularly as antioxidants and as a factor to catabolism and metabolism. The aim of this article is to correlate the level of vitamin C and the hydroxyproline level in urine samples among young palestinian children from age 5 - 14 years. Materials and Methods: Urine samples of 34 individuals of both sexes, their ages ranged from 5 - 14 years were collected and analyzed for determination of Urinary Hydroxyproline by using Modified Neuman and Logan Method. The result of this study shows a significant correlation between Vitamin C and Hydroxyproline at level 0.01. The conclusion of this study was that low vitamin C intake was found among young palestinian children from age 5 - 14 years, Vitamin C should be supplemented in the drinks taken by young palestinian children from age 5 - 14 years as well as further research and investigation with large samples required to include all children from middle and southern Palestine.

Cite this paper
Mahfouz, M. , Masri, I. , Mahfouz, H. and Mahfouz, Y. (2015) Correlation between Vitamin C Deficiency and Hydroxyproline Amino Acid in Young Children of Northern Part in Palestine. Open Journal of Pediatrics, 5, 151-155. doi: 10.4236/ojped.2015.52023.
References
[1]   Jacob, R.A. (1990) Assessment of Human Vitamin C Status. American Institute of Nutrition.

[2]   Lind, J. (1980) Treatise on the Scurvy. 3rd Edition, Classics of Medicine Library, Birmingham.

[3]   Chatterjee, G.C. (1967) Effects of Ascorbic Acid Deficiency in Animals. In: Sebrell Jr., W.H. and Harris, R.S., Eds., The Vitamins, Academic Press, New York, 407-457.

[4]   Gould, B.S. (1968) The Role of Certain Vitamins in Collagen Formation. In: Ramachandran, G.N. and Gould, B.S., Eds., Treatise on Collagen, Vol. 2A, Academic Press, New York, 323-365.

[5]   Watson, R.C., Grossman, H. and Meyers, M.A. (1980) Radiological Findings in Nutritional Disturbances. In: Goodhart, R.S., Shils, M.E., Eds., Modern Nutrition in Health and Disease, 6th Edition, Lea & Febiger, Philadelphia, 641-666.

[6]   Leggott, P.J., Robertson, P.B., Rothman, D.L., Murray, P.A. and Jacob, R.A. (1986) The Effect of Controlled Ascorbic Acid Depletion and Suppbementation on Periodontal Health. Journal of Periodontology, 7, 480-485.
http://dx.doi.org/10.1902/jop.1986.57.8.480

[7]   Buzina, R., Aurer-Kozelj, J., Srdak-Jorgic, K., Buhler, E. and Gey, K.F. (1986) Increase of Gingival Hydroxyproline and Proline by Improvement of Ascorbic Acid in Man. International Journal for Vitamin and Nutrition Research, 56, 367-372.

[8]   Wolfer, J.A., Farmer, C.I., Carroll, W.W. and Manshardt, D.O. (1947) An Experimental Study of Wound Healing in Vitamin C Depleted Human Subjects. Surgery, Gynecology, and Obstetrics, 84, 1-15.

[9]   Hodges, R.E. (1980) Ascorbic Acid. In: Goodhart, R.S. and Shils, M.E., Eds., Modem Nutrition in Health and Disease, 6th Edition, Lea & Febiger, Philadelphia, 259-273.

[10]   Barnes, M.J. and Kodicek, E. (1972) Biological Hydroxylation Sand Ascorbic Acid with Special Regard to Collagen Metabolism. Vitamins Hormones, 30, 1-43.

[11]   Barnes, M.J., Constable, B.J., Morton, L.F. and Kodicek, E. (1970) Studies in Vivo on the Biosynthesis of Collagen and Elastin in Ascorbic Acid Deficient Guinea Pigs. Evidence for the Formation and Degradation of a Partially Hydroxylated Collagen. Biochemical Journal, 19, 575-585.

[12]   Neuman, R.E. and Logan, M.A. (1950) The Determination of Hydroxyproline. Journal of Biological Chemistry, 184, 299.

[13]   Levine, M. (1986) New Concepts in the Biology and Biochemistry of Ascorbic acid. New England Journal of Medicine, 314, 892-901.
http://dx.doi.org/10.1056/NEJM198604033141407

 
 
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