Objective: To analyze the correlation between urine retinol binding
protein-4 (RBP-4) and serum HbA1c with glomerular filtration
rate (GFR) in type 1 diabetic children. Methods: This was a
crosssectional observational analytic study. The
subjects were type 1 diabetic children aged 2 - 14 years. Sample
collection was conducted from October to November 2014. Exclusion criteria were
patients with obesity, renal insufficiency that was not caused by
diabetes, history of hepatic diseases, and history of blood cell disorders.
We performed anamnesis, physical examination, and blood sampling for serum
HbA1c and serum cystatin-C, and urine sampling for
RBP-4 on all subjects. Glomerular filtration rate was calculated from the
concentration level of cystatin-C using Filler formula. Data analysis was
performed by Spearman test to determine the correlation between urine
RBP-4 and serum HbA1c with GFR. The Fisher’s exact test was
used to determine the correlation between duration of diabetes and RBP-4, HbA1c,
and also GFR. Results: Twelve females (60%) and 8 males (40%) participated
in the study. The mean age of the subjects with 95% CI was: 10.5 (2 - 14)
years while the mean age of duration diabetes with 95% CI: 3.8 (0.5 - 10)
years. Twelve (60%) subjects had <5 years duration of diabetes, while
eight (40%) subjects had ≥5 years duration of diabetes. Twelve (60%) subjects
had normal RBP-4 level, while eight (40%) subjects had elevated RBP-4
level. The mean level of HbA1c with 95% CI: 8.9 (5.1 - 15.2)%.
Thirteen (65%) subjects had poor metabolic. The mean GFR of the subjects with
95% CI: 99.3 (35.2 - 147.4) mL/1.73/m2. Nineteen (95%) subjects had
normal GFR, while 1 (5%) had renal insufficiency. The results of data analysis
using Spearman test on the correlation between urine RBP-4 and serum HbA1cwith
GFR were not significant. The result of correlation between duration of
diabetes and urine RBP-4 was significant using Fischer’s test.
Conclusion: The results showed no correlation between urine
RBP-4 and serum HbA1c with GFR. Urine RBP-4 could be
considered to assess renal function in type 1 diabetic patients with a duration
of diabetes of more than 5 years.
Cite this paper
Novery, E. , Susanah, S. and Rachmadi, D. (2015) The Correlation of Urine Retinol Binding Protein-4 and Serum HbA1c with Glomerular Filtration Rate in Type 1 (Insulin-Dependent) Diabetic Children: A Perspective on the Duration of Diabetes. Open Journal of Pediatrics
, 134-140. doi: 10.4236/ojped.2015.52020
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