Author(s) Francisco Sanchez¹, Jose Luis Gil¹, Macarena Perán²

Affiliation(s)
¹ Department of Biochemistry, Molecular Biology and Immunology, University of Málaga, Málaga, Spain.
² Department of Health Sciences, University of Jaén, Jaén, Spain.

ABSTRACT

Lymphocytes respond to mitogens that stimulate proliferation by increasing theirs metabolic activity. In this study we investigate L-Glutamine and L-Leucine uptake as markers of cell response to Concavalina A (ConcaA) stimulation, using a high-resolution flow technique. We found that lymphocytes induced to blast transformation enhanced rate and efficiency of amino acid uptake during cell proliferation. Considering that increases in transport is the first quantifiable response of cells during malignant transformation, amino acid uptake could also be useful as an early marker of malignancy.

KEYWORDS
Cell Membrane Transport, Lymphocytes, L-Glutamine, L-Leucine, Malignancy Biomarkers

Cite this paper
Sanchez, F. , Gil, J. and Perán, M. (2015) Modifications of L-Glutamine and L-Leucine Transport in Proliferating Lymphocytes. Journal of Biosciences and Medicines, 3, 104-109. doi: 10.4236/jbm.2015.33016.

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