Lymphocytes respond to mitogens that stimulate
proliferation by increasing theirs metabolic activity. In this study we
investigate L-Glutamine and L-Leucine uptake as markers of cell response to
Concavalina A (ConcaA) stimulation, using a high-resolution flow technique. We
found that lymphocytes induced to blast transformation enhanced rate and
efficiency of amino acid uptake during cell proliferation. Considering that
increases in transport is the first quantifiable response of cells during
malignant transformation, amino acid uptake could also be useful as an early
marker of malignancy.
Cite this paper
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