AJPS  Vol.6 No.8 , May 2015
Effect of Selective Medicinal Plant Extract on Blood Glucose, Sperm Shape and Various Physiological Parameters
Abstract: Salvadora persica, Moringa pergrina and Citrullus colocynthis are three traditional important medicinal species used in indigenous medicinal herbal drugs to cure various diseases in South Asia and Middle East countries. The objective of the present study is to investigate the effects of oral administration of extracts of Salvadora persica leaves, Moringa pergrina leaves and Citrullus colocynthis seeds on different physiological parameters of mice. The leaves of Salvadora persica, Moringa pergrina and Citrullus colocynthis seeds were collected from Ibri and Al-Musanaa, dried and crushed into powder and extract was obtained by soxhalet apparatus. The extract was then administered to mice at a dosage of 0.5%, 1.0%, 1.5% and 2.0% for twenty one days. The mice treated with different concentrations of plant extracts showed different physiological changes, Salvadora persica leaf extract at 1.5% and 2.0% showed hypo activity, grooming, prostration, while mice treated with 0.5% and 1.0% showed no effective behavioral changes. The Moringa pergrina leaf extract dosage of 0.5%, 1.0%, 1.5% and 2.0% produced significant weight loss and affected the blood sugar level. Citrullus colocynthis seed extract at 1.5% and 2.0% showed abnormal sperms shape like circular head, double head and double tails whereas at 0.5% and 1.0% exhibited normal sperm shape.
Cite this paper: Reddy, S. , Al-Neeri, I. , Al-Issaei, H. and Al-Jabri, S. (2015) Effect of Selective Medicinal Plant Extract on Blood Glucose, Sperm Shape and Various Physiological Parameters. American Journal of Plant Sciences, 6, 1109-1115. doi: 10.4236/ajps.2015.68115.

[1]   Selin, H. and Shapiro, H. (2003) Medicine across Cultures: History and Practice of Medicine in Non-Western Cultures. Springer, Berlin, 35.

[2]   Askitopoulou, H., Konsolaki, E., Ramoutsaki, I. and Anastassaki, E. (2002) Surgical Cures by Sleep Induction as the Asclepieion of Epidaurus. International Congress Series, 1242, 11-17.

[3]   Khan, M., Ali, M., Ali, A. and Mir, S.R. (2014) Hypoglycemic and Hypolipidemic Activities of Arabic and Indian Origin Salvadora persica Root Extract on Diabetic Rats with Histopathology of Their Pancreas. International Journal of Health Sciences (Qassim), 8, 45-56.

[4]   Huseini, H.F., Darvishzadeh, F., Heshmat, R., Jafariazar, Z., Raza, M. and Larijani, B. (2009) The Clinical Investigation of Citrullus colocynthis (L.) Schrad Fruit in Treatment of Type II Diabetic Patients: A Randomized, Double Blind, Placebo-Controlled Clinical Trial. Phytotherapy Research, 23, 1186-1189.

[5]   El-Alfy, T.S., Ezzat, S.M., Hegazy, A.K., Amer, A.M. and Kamel, G.M. (2011) Isolation of Biologically Active Constituents from Moringa peregrina (Forssk.) Fiori. (Family: Moringaceae) Growing in Egypt. Pharmacognosy Magazine, 7, 109-115.

[6]   Dangi, S.Y., Jolly, C.I. and Narayanan, S. (2002) Antihypertensive Activity of Total Alkaloids from the Leaves of Moringa oleifera. Journal of Pharmaceutical Biology, 40, 144-148.

[7]   Ali, B.H., Tanira, M.O., Bashir, A.K. and Al-Qarawi, A.A. (2000) Effect of Rhazyastricta Dence on Monoamine Oxidase and Cholinesterase Activity and Brain Biogenic Amine Levels in Rats. Journal of Pharmacy and Pharmacology, 52, 1297-1300.

[8]   Tanira, M.O., Ali, B.H., Bashir, A.K. and Chandranath, I. (1996) Some Pharmacologic and Toxicologic Studies on Rhazyastricta Dence in Rats, Mice and Rabbits. General Pharmacology, 27, 1261-1267.

[9]   Vadivelan, R., Dipanjan, M., Umasankar, P., Dhanabal, S.P., Satishkumar, M.N., Antony, S. and Iango, E.K. (2011) Hypoglycemic, Antioxidant and Hypolipidemic Activity of Asparagus racemosus on Streptozotocin-Induced Diabetic in Rats. Advances in Applied Science Research, 2, 179-185.

[10]   Grover, J.K., Yadav, S. and Vats, V. (2002) Medicinal Plants of India with Antidiabetic Potential. Journal of Ethnopharmacology, 81, 81-100.

[11]   Bayala, B., Telefo, P.B., Bassole, I.H.N., Tamboura, H.H., Belemtougri, R.G., Sawadogo, L., Malpaux, B. and Dacheux, J.L. (2011) Anti-Spermatogenic Activity Leptadeniahastata Leaf Stems Aqueous Extracts in Male Wistar Rats. Journal of Pharmacology and Toxicology, 6, 391-399.

[12]   Taguchi, H. and Armarego, W.L.F. (1998) Glyceryl Ether Monooxygenase (EC A Microsomal Enzyme of Ether Lipid Metabolism. Medicinal Research Reviews, 18, 43-88.

[13]   Amole, O., Izegbu, M., Onakoya, A. and Dada, M. (2006) Toxicity Studies of the Aqueous Extract of Vernonia amygdalina. Journal of Biomedical Research, 17, 39-40.

[14]   Lans, C. and Brown, G. (1998) Ethnoveterinary Medicines Used for Ruminants in Trinidad and Tobago. Preventive Veterinary Medicine, 35, 149-163.

[15]   Guarrera, P.M. (2005) Traditional Phytotherapy in Central Italy (Marche, Abruzzo and Latium). Fitoterapia, 76, 1-25.

[16]   Al Lafi, T. and Ababneh, H. (1995) The Effect of the Extract of the Miswak (Chewing Sticks) Used in Jordan and the Middle East on Oral Bacteria. International Dental Journal, 45, 218-222.