Objectives: The balance of the vaginal ecosystem
depends on lactobacilli whose biofilm protectsagainst microorganisms that are
not normally present or are subdominant in vaginal flora. Vaginal infection treatments should eliminate
pathogens while preserving the Lactobacillus flora to prevent relapse or recurrence. The objective
of this study was to determine the sensitivity of lactobacilli to antiseptics,
antibiotics and antifungal agents used, alone or in combination, in the topical
treatment of infectious vaginitis. Materials and Methods: The minimum
inhibitory concentration (MIC) of 15 active ingredients and the minimum
inhibitory dilution (MID) of 17 pharmaceuticals products were determined for
three main Lactobacillus strains (L.
gasseri and L. jensenii).
Results: The MICs of the antibiotics and antifungal agents were above their
critical concentrations in the three strains, contrary to the antiseptics.
According to their MID, some pharmaceutical products, especially combinations,
inhibit the growth of one or more strains at concentrations that can be found
in the vaginal mucosa after application at the usual dosage. Conclusions:
Certain topical anti-infective drugs may interfere with the growth of
lactobacilli, worsening the vaginal flora imbalance. Maintaining vaginal flora
balance should be a selection criterion when choosing an anti-infective therapy.
Cite this paper
Neut, C. , Verrière, F. , Nelis, H. and Coenye, T. (2015) Topical Treatment of Infectious Vaginitis: Effects of Antibiotic, Antifungal and Antiseptic Drugs on the Growth of Normal Vaginal Lactobacillus
Strains. Open Journal of Obstetrics and Gynecology
, 173-180. doi: 10.4236/ojog.2015.53024
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