Back
 FNS  Vol.6 No.3 , March 2015
Effects of Biebersteinia multifida DC. Root Extract on Physical Stamina in Male Mice
Abstract: Biebersteinia multifida DC. has been used for the purpose of development of physical strength in iranian folk medicine. In the present study, we investigated the effect of Biebersteinia multifida DC. root extract on performance of the Forced Swimming Test (FST), and on blood biochemical parameters related to fatigue: Blood Urea Nitrogen (BUN), Creatine Kinase (CK), Lactic Dehydrogenase (LDH), Glucose (Glc), and Total Protein (TP). Biebersteinia multifida DC. root extract was orally administered to mice at the doses 4, 7 and 10 mg/kg continuously once per day for 1 and 7 days using a feeding atraumatic needle. After 7 days, on FST the immobility time was decreased in the treated-groups at the doses 4 and 7 mg/kg, but after 1 day, only the immobility time of the treated- group at the dose of 4 mg/kg was decreased significantly. In addition, the content of Glc and TP in the blood serum was significantly increased in the groups receiving 4 and 7 mg/kg of Biebersteinia multifida DC. root extract for 7 days and LDH was decreased significantly. However, the levels of BUN and CK did not show a significant change. The results predict a potential benefit of Biebersteinia multifida DC. root extract as an anti-fatigue treatment and for improving physical stamina.
Cite this paper: Jahromy, M. , Mohajer, A. , Adibi, L. and Khakpour, S. (2015) Effects of Biebersteinia multifida DC. Root Extract on Physical Stamina in Male Mice. Food and Nutrition Sciences, 6, 326-331. doi: 10.4236/fns.2015.63032.
References

[1]   Davis, P.H. (1967) Flora of Turkey. Edinburg University Press, Edinburgh, 451.

[2]   Reschinger, K.H. (1970) Flora Iranica. Geraniaceae, 1, 63.

[3]   Farsam, H., Amanlou, M., Dehpour, A.R. and Jahaniani, F. (2000) Anti-Inflammatory and Analgesic Activity of Biebersteinia multifida DC. Root Extract. Journal of Ethnopharmacology, 71, 443-447.
http://dx.doi.org/10.1016/S0378-8741(00)00174-4

[4]   Kurbanov, D. and Zharekeev, B.Kh. (1974) Alkaloid of Biebersteinia multifida and Peganum harmala from the Katakapak ASSR. Through Chemical Abstract 82, 83023b. Khim. Prir. Soedin, 5, 685-686.

[5]   Arifkhodzhaev, A.O., Arifkhodzhaev, Kh.A. and Kondratenko, E.S. (1985) Polysaccharides from Saponin-Containing Plants. 11. Isolation and Characterization of Polysaccharides from Biebersteinia multifida. Through Chemical Abstract 104, 165369f. Khim. Prir. Soedin, 16, 755-757.

[6]   Arifkhodzhaev, A.O. and Rakhimov, D.A. (1987) Polysaccharides from Saponin-Containing Plants. 111. Polysaccharides of the Aerial Parts of Biebersteinia multifida. Through Chemical Abstract 106, 153118. Khim. Prir. Soedin, 6, 773-774.

[7]   Zhang, X.F., Hu, B. and Zhou, B.N. (1995) Studies on the Active Constituent of Tiberan Herb Biebersteinia heterostemon Maxim. Acta Pharmaceutica Sinica, 30, 211-214.

[8]   Borsini, F. and Meli, A. (1988) Is the Forced Swimming Test a Suitable Model for Revealing Antidepressant Activity? Psychopharmacology (Berlin), 94, 147-160.
http://dx.doi.org/10.1007/BF00176837

[9]   Kim, K.M., Yu, K.W., Kang, D.H. and Suth, H.J. (2002) Anti-Stress and Anti-Fatigue Effect of Fermented Rice Bran. Phytotherapy Research, 16, 700-702.
http://dx.doi.org/10.1002/ptr.1019

[10]   Novelli, G.P., Falsini, S. and Bracciotti, G. (1990) Exogenous Glutathione Increases Endurance to Muscle Effort in Mice. Pharmacological Research, 23, 149-155.
http://dx.doi.org/10.1016/S1043-6618(05)80116-1

[11]   Ozturk, N., Baser, K.H., Aydin, S., Ozturk, Y. and Calis, I. (2002) Effects of Gentiana lutea ssp. Symphandra on the Central Nervous System in Mice. Phytotherapy Research, 16, 627-631.

[12]   Volfinger, L., Lassourd, V., Michaux, J.M., Braun, J.P. and Toutain, P.L. (1994) Kinetic Evaluation of Muscle Damage during Exercise by Calculation of Amount of Creatine Kinase Released. American Journal of Physiology, 266, R434R441.

[13]   Coombes, J.S. and McNaughton, L.R. (2000) Effects of Branched-Chain Amino Acid Supplementation on Serum Creatine Kinase and Lactate Dehydrogenase after Prolonged Exercise. Journal of Sports Medicine and Physical Fitness, 40, 240-246.

[14]   Wu, J.L., Wu, Q.P., Huang, J.M., Chen, R., Cai, M. and Tan, J.B. (2006) Effects of L-Malate on Physical Stamina and Activities of Enzymes Related to the Malate-Aspartate Shuttle in Liver of Mice. Physiological Research, 56, 213-220.

[15]   Porsolt, R., Bertin, A. and Jalfer, M. (1977) Behavioral Despair in Mice: A Primary Screening Test for Antidepressant. Archives Internationales de Pharmacodynamie et de Thérapie, 229, 327-336.

[16]   Koo, H.N., Lee, J.K., Hong, S.H. and Kim, H.M. (2004) Herbkines Increases Physical Stamina in Mice. Biological and Pharmaceutical Bulletin, 27, 117-119.
http://dx.doi.org/10.1248/bpb.27.117

 
 
Top