AMPC  Vol.5 No.3 , March 2015
Preparation and Characterization of Holmium-Beta-Cyclodextrin Complex
ABSTRACT
The purpose of this study was to prepare and characterize of holmium-beta-cyclodextrin complex (Ho-β-CD) in order to increase the solubility and stability of Holmium. To achieve this goal, Ho-β-CD complex was prepared by evaporation method of holmium and beta cyclodextrin solutions in a proportion (1:1) and (1:3), respectively. Infrared (IR) and Raman spectroscopy, X-Ray Diffraction were performed to identify the complex. Morphology of the Ho, β-CD, and Ho-β-CD were studied using Scanning Electron Microscopy (SEM).

Cite this paper
Rojas-Mena, A. , López-González, H. and Rojas-Hernández, A. (2015) Preparation and Characterization of Holmium-Beta-Cyclodextrin Complex. Advances in Materials Physics and Chemistry, 5, 87-94. doi: 10.4236/ampc.2015.53011.
References
[1]   Abdelrahman, A.I. (2011) Lanthanide-Encoded Polystyrene Microspheres for Mass Cytometry-Based Bioassays. Thesis, Department of Chemistry, University of Toronto, Toronto.

[2]   Zielhuis, S. (2006) Radioactive Particles for Cancer Therapy and Multimodality Imaging. Thesis, University Medical Center Utrecht, Utrecht.

[3]   Baran, E.J. (2007) La Nueva Farmacoterapia Inorgánica. XVIII. Compuestos de Lantánidos. Latin American Journal of Pharmacy, 26, 626-634.

[4]   Lyra, M., Andreou, M., Georgantzoglou, A., Kardolaimi, S., Lagopati, N., Ploussi, A. and Salvara, A.L. (2011) Ionnis Vamvakas. Nuclear Medicine Therapy. Radiositopes Production and Dosimetry, 2-6.

[5]   IAEA-TECDOC-1228 (2011) Herapeutic Applications of Radiopharmaceuticals. Proceedings of an International Seminar, Hyderabad, 18-22 January 1999, 1-6.

[6]   Lira, R.A., Myamoto, D.M., Souza, J.R., Nascimento, N., Osso Junior, J.A., Martinelli, J.R. and de Burgos M. de Azevedo, M. (2011) Microspheres with an Ultra-High Holmium Content for Brachytherapy of Malignancies. 2011 International Nuclear Atalntic Conference-INAC 2011, Belo Horizonte, 24-28 October 2011, 12 p.

[7]   Yavari, K., Hadi, K., Mohamad, T., Mazidi, M., Bagher, K., Asl, R.S. and Maragheh, M.G. (2013) Development of 166Ho Poly Lactic Acid Microspheres for Radiosynovectomy. Journal of Pharamacy and Pharmacolgy, 1, 25-35.

[8]   de Lacerda, S.M.V. (2009) Copper, Samarium and Holmium Complexes with Tetraazamacrocycles Potencially Interesting for Nuclear Medicine. Thesis, Departamento de Química e Bioquímica, Faculdad de Ciencias, Universidade de Lisboa, Loures.

[9]   Loftsson, T. and Brewster, M.E. (1996) Pharmaceutical Applications of Cycldextrins. 1. Drug Solubilization and Stabilization. Journal of Pharamceutical Science, 85, 1017-1025.
http://dx.doi.org/10.1021/js950534b

[10]   Moscoso, D.A. (2010) Multifunctional Platforms Based on Cyclodextrins: Design Antitoxins of Anthrax and Gene Vectors. PhD Thesis, Institute of Chemical Research of the Higher Council for Scientific Research, Department of Chemistry, University of Sevilla, Sevilla.

[11]   Prakash Rao, B., Sarasija, S., Narendra, C. and Balasangameshwer (2006) Physicochemical Characterization of β-Cyclodextrin and Hydroxy Ethyl β-Cyclodextrin Complexes of Rifampicin. ARS Pharmaceutica, 47, 37-59.

[12]   Martinez, G. and Gamez, M.A. (2007) Cyclodextrins: Inclusion Complexes with Polymers. Revista Iberoamericana de Polymers, 8, 300-312.

[13]   Restrepo, J., Vinasco, L.E., Jaramillo, L.P. and Colmenares, A.J. (2009) Encapsulation of Essential Oils Citral (Cymbopogon citratus) in β-Cyclodextrins Using Supercritical CO2. Engineering and Competitiveness Magazine, 11, 9-19.

[14]   Sambasevam, K.P., Mohamad, S., Sarih, N.M. and Ismail, N.A. (2013) Synthesis and Characterization of the Inclusion Complex of β-Cyclodextrin and Azomethine. International Journal of Molecular Sciences, 14, 3671-3682.
http://dx.doi.org/10.3390/ijms14023671

[15]   Wang, H.Y., Han, J. and Xia, G.F. (2007) Spectroscopy Study of Orange G-β-Cyclodextrin Complex and Its Analytical Application. Spectrochimica Acta Part A: Molecular and Biomolecular, 66, 578-585.
http://dx.doi.org/10.1016/j.saa.2006.03.035

[16]   Balboul, B.A.A.A. (2000) Physicochemical Characterization of the Decomposition Course of Hydrated Holmium Nitrate. Thermoanalytical Studies. Powder Technology, 107, 168-174.
http://dx.doi.org/10.1016/S0032-5910(99)00183-7

[17]   Maixner, J. and Bartunek, V. (2012) X-Ray Powder Diffraction Data for Holmium Nitrate Pentahydrate. Powder Diffraction Pattern, 27, 203-207.

 
 
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