OJMM  Vol.5 No.1 , March 2015
Bacterial Uropathogen among Benign Prostatic Hyperplasia Patients at a Tertiary Hospital in Nigeria
As the lumen of the prostatic urethra becomes compromised by fibroadenomatous growth in the periurethral region of the prostate of men with Benign prostatic hyperplasia (BPH), urine outflow is obstructed progressively resulting in incomplete bladder empting causing stasis and may predispose patients to infection. Mid stream urine samples were collected from 94 BPH patients. Macroscopy, microscopy, culture and antibiotic susceptibility test were carried out on isolated uropathogens. Isolated bacteria were characterized using biochemical tests. Isolated bacterial pathogens include Proteus mirabilis, Escherichia coli, Pseudomonas aeruginosa, Klebsiella oxytoca, Morgarella morgani, K. pneumonia and Enterococcus faecalis in order of frequency. The isolates show highest resistance of 87.1% to Ciprofloxacin and least resistance of 12.9% to Imipenem. The isolates were found to be multi-drug resistant and the 12.9% resistance to Imipenem suggests presence of Carbapenemase producing bacteria among the isolates.

Cite this paper
Oshodi, A. , Nwabuisi, C. , Popoola, A. , Edungbola, L. , Agbede, O. , Akanbi II, A. , Fadeyi, A. and Raheem, R. (2015) Bacterial Uropathogen among Benign Prostatic Hyperplasia Patients at a Tertiary Hospital in Nigeria. Open Journal of Medical Microbiology, 5, 22-27. doi: 10.4236/ojmm.2015.51004.
[1]   Chan, S.W. (2011) Pathology and Medical Therapy of Benign Prostatic Hyperplasia. The Hong Kong Medical Diary, 16, 4-7.

[2]   Chedi, B.A.Z., Wannang, N.N., Halliru, M.A. and Bichi, L.A. (2009) A Seven Months Retrospective Study on Urinary Tract Infection among Patient at Aminu Kano Teaching Hospital, Kano-Nigeria. Bayero Journal of Pure and Applied Science, 2, 95-98.

[3]   Forbes, B.A., Sahm, D.F. and Weissfeld, A.S. (2007) Bailey and Scott’s Diagnostic Microbiology. 12th Edition, Mosby Elsevier, China, 842-855.

[4]   Getenet, B. and Wondewosen, T. (2011) Bacteria Uropathogen in Urinary Tract Infection and Antibiotic Susceptibility Pattern in Jimma University Specialized Hospital, Southwest Ethiopia. Ethiopian Journal of Health Sciences, 21, 141-146.

[5]   Ryan, K.J. (2004) Urinary Tract Infections. In: Ryan, K.J. and Ray, C.G., Eds., Sherris Medical Microbiology an Introduction to Infectious Diseases, McGraw-Hill, New York, 867-871.

[6]   Crowford, E.D. and Dall’Era, J. (2006) Benign Prostatic Hyperplasia and Progression of Lower Urinary Tract Symptom—A Review. US Genito-Urinary Disease, 44-46.

[7]   Stamm, W.E. (2005) Urinary Tract Infections and Pyelonephritis. In: Kasper, D.L., Fanci, A.S., Longo, D.L., Braunwald, S.L., Hanser and Jameson, J.L., Eds., Harrison Principles of Internal Medicine, 16th Edition, McGraw Hill, New York, 1715-1721.

[8]   Oni, A.A., Mbah, G.A., Ogunkunle, M.O., Shitu, O.B. and Bakare, R.A. (2003) Nosocomial Infection: Urinary Tract Infection in Patients with Indwelling Catheter. African Journal of Clinical & Experimental Microbiology, 4, 63-71.

[9]   Taiwo, S.S. and Aderounmu, A.O.A. (2006) Catheter Associated Urinary Tract Infection: Aetiologic Agents and Antimicrobial Susceptibility Pattern in Ladoke Akintola University Teaching Hospital, Osogbo, Nigeria. African Journal of Biomedical Research, 9, 141-148.

[10]   Chan, S.S., Chan, K.K., Lin, A.T., Chang, Y.H., Wu, H.H., Hsu, T.H., Chin, A.W. and Chang, L.S. (1998) Complicated Urinary Tract Infection: Analysis of 179 Patients. Zhoughua Yi Xue Za Zhi (Taipei), 61, 651-656.

[11]   Barkin, J. (2011) Benign Prostatic Hyperplasia and Lower Urinary Tract Symptoms: Evidence and Approaches for Best Case Management. Canadian Journal of Urology, 18, 14-19.

[12]   Lepor, H. (2004) Evaluating Men with Benign Prostatic Hyperplasia. Reviews in Urology, 6, S8-S15.

[13]   Adegoke, A.O., Bamigbowu, O.E., Ayodele, M.B.O. and Blankson, C.D. (2012) Prevalence of Asymptomatic Bacteriuria in Prostatitis Subjects Attending University of Port Harcourt Teaching Hospital. African Journal of Microbiology Research, 6, 4443-4448.

[14]   Oshodi, A.J., Nwabuisi, C., Popoola, A.A., Edungbola, L.D., Agbede, O.O., Akanbi II, A.A., Fadeyi, A., Nyanmgee, A., Adeyemi, O. and Raheem, R.A. (2014) Association between Benign Prostatic Hyperplasia and Urinary Tract Infection. Continental Journal of Biomedical Sciences, 8, 7-11.

[15]   Gichobi, D., Wanzala, P., Mutai, J. and Kamweya, A. (2010) Factors Associated with Disease Outcome in Children at Kenyatta National Hospital. Journal of Public Health and Epidemiology, 2, 262-266.

[16]   Hurst, F.P., Neff, R.T., Falta, E.M., Jindal, R.M., Lentine, K.L., Swanson, J.S., Agodoa, L.Y. and Abbott, K.C. (2009) Incidence, Predictors, and Associated Outcomes of Prostatism after Kidney Transplantation. Clinical Journal of the American Society of Nephrology, 4, 329-336.

[17]   Nicolle, L.E. (2005) Complicated Urinary Tract Infection in Adults. Canadian Journal of Infectious Diseases & Medical Microbiology, 16, 349-360.

[18]   Auda, J.G. and Al-Grawi, I.G. (2009) Isolation, Identification and Antimicrobial Susceptibility of Uropathogenic Morganella morganii. Al-Kindy College Medical Journal, 5, 32-35.