Preparation of Composite Particles Made of Biodegradable Polymer and a Few Additives with Phase Separation Followed by Drying-in-Liquid
ABSTRACT
It was tried to prepare the biodegradable composite particles by the phase separation method followed by the drying-in-liquid method. The composite particles were made of poly-ε-caprolac-tone, quaternary ammonium, carbon black and wax. In the experiment, acetone and water were selected as a good solvent and a poor solvent for poly-ε-caprolactone, quaternary ammonium and wax, respectively. The composite particles were prepared by changing the surfactant species and their concentration, the feeding velocity of water and the weight ratio of poly-ε-caprolactone with larger molecular weight to one with smaller molecular weight. The composite particles with the inner structure in which carbon black, quaternary ammonium and wax were coated well with poly-ε-caprolactone could be prepared by the preparation method presented in this study. The structure and the mean diameter of composite particles were strongly affected by the feeding velocity of water. The higher the feeding velocity of water, the larger the mean diameter of composite particles. The mean diameter was drastically decreased with the surfactant concentration and increased with the added amount of poly-ε-caprolactant with larger molecular weight.
It was tried to prepare the biodegradable composite particles by the phase separation method followed by the drying-in-liquid method. The composite particles were made of poly-ε-caprolac-tone, quaternary ammonium, carbon black and wax. In the experiment, acetone and water were selected as a good solvent and a poor solvent for poly-ε-caprolactone, quaternary ammonium and wax, respectively. The composite particles were prepared by changing the surfactant species and their concentration, the feeding velocity of water and the weight ratio of poly-ε-caprolactone with larger molecular weight to one with smaller molecular weight. The composite particles with the inner structure in which carbon black, quaternary ammonium and wax were coated well with poly-ε-caprolactone could be prepared by the preparation method presented in this study. The structure and the mean diameter of composite particles were strongly affected by the feeding velocity of water. The higher the feeding velocity of water, the larger the mean diameter of composite particles. The mean diameter was drastically decreased with the surfactant concentration and increased with the added amount of poly-ε-caprolactant with larger molecular weight.
KEYWORDS
Biodegradable Composite Particles, Phase Separation, Drying-in-Liquid, Poly-ε-Caprolactone, Microencapsulation
Biodegradable Composite Particles, Phase Separation, Drying-in-Liquid, Poly-ε-Caprolactone, Microencapsulation
Cite this paper
Kutsuwada, M. , Taguchi, Y. and Tanaka, M. (2015) Preparation of Composite Particles Made of Biodegradable Polymer and a Few Additives with Phase Separation Followed by Drying-in-Liquid. Journal of Encapsulation and Adsorption Sciences, 5, 11-20. doi: 10.4236/jeas.2015.51002.
Kutsuwada, M. , Taguchi, Y. and Tanaka, M. (2015) Preparation of Composite Particles Made of Biodegradable Polymer and a Few Additives with Phase Separation Followed by Drying-in-Liquid. Journal of Encapsulation and Adsorption Sciences, 5, 11-20. doi: 10.4236/jeas.2015.51002.
References
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http://dx.doi.org/10.4236/jeas.2013.33011 [17] Jiang, A., Fang, X., Yu, Q., Deng, J. and Yang, W. (2012) New Route to Monodispersed Amphiphilic Core-Shell Polymer Nanoparticles: Polymerization of Styrene from α-Methylstyrene-Containing Macroinitiator. Journal of Applied Polymer Science, 124, 4121-4126. http://dx.doi.org/10.1002/app.35266 [18] Huang, Z., Wang, C., Li, Y. and Wang, Z. (2012) Controlled Preparation of Core-Shell Polystyrene/Polypyrrole Nanocomposite Particles by a Swelling-Diffusion-Interfacial Polymerization Method. Colloid and Polymer Science, 290, 979-985. http://dx.doi.org/10.1007/s00396-012-2663-5 [19] Fuchigami, K., Taguchi, Y. and Tanaka, M. (2008) Preparation of Microcapsules Containing TMBA (1,3,5-Trimethylbarbituric Acid) by the Drying-in-Liquid Method and Its Application. Journal of Applies Polymer Sciences, 110, 2145-2152. http://dx.doi.org/10.1002/app.28825
[1] Kondo, T. (1967) Saishin Maikurokapseruka Gijutsu (Microencapsulation Technique). TES, Tokyo. (In Japanese) [2] Tanaka, M. (2008) Key Point of Preparation of Nano/microcapsules. Techno System Publishing Co. Ltd., Tokyo. [3] Sendil, D., Gürsel, I., Wise, D.L. and Hasirci, V. (1999) Antibiotic Release from Biodegradable PHBV Microparticles. Journal of Controlled Release, 59, 207-217. http://dx.doi.org/10.1016/S0168-3659(98)00195-3 [4] Hong, K. and Park, S. (2000) Preparation of Poly(l-lactide) Microcapsules for Fragrant Fiber and Their Characteristics. Polymer, 41, 4567-4572. http://dx.doi.org/10.1016/S0032-3861(99)00677-1 [5] Zhao, G.H., Liu, Y., Fang, C.L., Zhang, M., Zhou, C.Q. and Chen, Z.D. (2006) Water Resistance, Mechanical Properties and Biodegradability of Methylated-Cornstarch/Poly(vinyl alcohol) Blend Film. Polymer Degradation and Stability, 91, 703-711. http://dx.doi.org/10.1016/j.polymdegradstab.2005.06.008 [6] Lee, J.I. and Yoo, H.S. (2008) Biodegradable Microspheres Containing Poly(ε-caprolactone)-Pluronicblock Copolymers for Temperature-Responsive Release of Proteins. Colloids and Surfaces B: Biointerface, 61, 81-87.
http://dx.doi.org/10.1016/j.colsurfb.2007.07.008 [7] Gao, Y.T., Shen, P.Y., Wang, B.H., Lü, S.D., Huang, G.C. and Ho, L.S. (1984) Controlled Release Effect of Insecticide Microcapsules and Their Results in Common Household Insect Pest Control. Journal of Microencapsulation, 1, 307-315. http://dx.doi.org/10.3109/02652048409031543 [8] Hirech, K., Payan, S., Carnelle, G., Brujes, L. and Legrand, J. (2003) Microencapsulation of an Insecticide by Interfacial Polymerization. Powder Technology, 130, 324-330. http://dx.doi.org/10.1016/S0032-5910(02)00211-5 [9] Takahashi, T., Taguchi, Y. and Tanaka, M. (2005) Preparation of Polyurea Microcapsules Containing Pyrethroid Insecticide with Hexamethylene Diisocyanate Uretidione and Isocyanurate. Journal of Chemical Engineering of Japan, 38, 929-936. http://dx.doi.org/10.1252/jcej.38.929 [10] Taguchi, Y., Yamada, Y., Ishikura, Y. and Tanaka, M. (2003) Preparation of Biodegradable Capsules Composed of Paper Fibers by Utilizing Liquid-Liquid Dispersion. Journal of Chemical Engineering of Japan, 36, 1236-1241.
http://dx.doi.org/10.1252/jcej.36.1236 [11] Sonia, T.A., Rekha, M.R. and Sharma, C.P. (2011) Bioadhesive Hydrophobic Chitosan Microparticles for Oral Delivery of Insulin: In Vitro Characterization and in Vivo Uptake Studies. Journal of Applied Polymer Science, 119, 2902-2910. http://dx.doi.org/10.1002/app.32979 [12] Naidu, B.V.K. and Paulson, A.T. (2011) A New Method for the Preparation of Gelatin Nanoparticles: Encapsulation and Drug Release Characteristics. Journal of Applied Polymer Science, 121, 3495-3500.
http://dx.doi.org/10.1002/app.34171 [13] Rekha, M.R. and Sharma, C.P. (2011) Glutamine-Chitosan Microparticles as Oral Insulin Delivery Matrix: In Vitro Characterization. Journal of Applied Polymer Science, 122, 2374-2382.
http://dx.doi.org/10.1002/app.34315 [14] Hirano, N., Shimoyama, A. and Uchizono, A. (1995) Japanese Patent No. 7-70116. [15] Miyazaki, K., Yanagihori, A., Takahashi, N. and Yamaoka, H. (1996) Japanese Patent No. 8-90927. [16] Yokoyama, Y., Fuchigami, K., Taguchi, Y. and Tanaka, M. (2013) Preparation of Microcapsules with Liquid Droplet Coalescence Method Followed by Phase Separation. Journal of Encapsulation and Adsorption Sciences, 3, 93-97.
http://dx.doi.org/10.4236/jeas.2013.33011 [17] Jiang, A., Fang, X., Yu, Q., Deng, J. and Yang, W. (2012) New Route to Monodispersed Amphiphilic Core-Shell Polymer Nanoparticles: Polymerization of Styrene from α-Methylstyrene-Containing Macroinitiator. Journal of Applied Polymer Science, 124, 4121-4126. http://dx.doi.org/10.1002/app.35266 [18] Huang, Z., Wang, C., Li, Y. and Wang, Z. (2012) Controlled Preparation of Core-Shell Polystyrene/Polypyrrole Nanocomposite Particles by a Swelling-Diffusion-Interfacial Polymerization Method. Colloid and Polymer Science, 290, 979-985. http://dx.doi.org/10.1007/s00396-012-2663-5 [19] Fuchigami, K., Taguchi, Y. and Tanaka, M. (2008) Preparation of Microcapsules Containing TMBA (1,3,5-Trimethylbarbituric Acid) by the Drying-in-Liquid Method and Its Application. Journal of Applies Polymer Sciences, 110, 2145-2152. http://dx.doi.org/10.1002/app.28825