Background: Several epidemiological studies have been carried to identify
the risk factors for developing breast cancer. The aim of this study was to
evaluate the risk factors associated with breast cancer in different age groups
in the Moroccan women and to determine susceptible and protective factors.
Methods: This was a case control study including 400 women with
breast cancer and 400 controls of the National Institute of Oncology Sidi
Mohamed Ben Abdallah, Rabat, Morocco from 2008 to 2010. These women were
interviewed for epidemiological information and risk factor for breast cancer.
Results: Early age at menarche, late menopause, oral contraceptive and family
history with first degree were positively associated with breast cancer in all
the series and in the age group between 22 and 34 years. In the age group
between 44 and 34 years, a risk of breast cancer was associated only with a
family history of breast cancer. In the age group of 45 years or older, the
factors which seem to influence a breast cancer are: late menopause, oral
contraceptive and family history in the first degree. In contrast, early
childbearing, multiparity and lactation were negatively associated with breast
cancer. Conclusion: This study is rather in favour of positive association between
hormonal factors and breast cancer, and confirms the protective role of
multiparity and lactation.
Cite this paper
Laamiri, F. , Bouayad, A. , Hasswane, N. , Ahid, S. , Mrabet, M. and Amina, B. (2015) Risk Factors for Breast Cancer of Different Age Groups: Moroccan Data?. Open Journal of Obstetrics and Gynecology
, 79-87. doi: 10.4236/ojog.2015.52011
 Fearly, J., Shin, H.R., Bray, F., Forman, D., Mathers, C. and Parkin, D.M. (2010) Estimates of World Wide Burden of Cancer in 2008: GLOBOCAN 2008. International Journal of Cardiology, 127, 2893-2917.
 Key, T.J. and Pike, M.C. (1988) The Role of Oestrogens and Progestagens in the Epidemiology and Prevention of Breast Cancer. European Journal of Cancer and Clinical Oncology, 24, 29 -43.
 Einbeigi, Z., Bergman, A., Kindblom, L.G., et al. (2001) A Founder Mutation of the BRCA1 Gene in Western Sweden Associated with a High Incidence of Breast and Ovarian Cancer. European Journal of Cancer, 37, 1904-1909.
 Nkondjock, A. and Ghadirian, P. (2005) Facteurs de risque du cancer du sein. M/S, 21, 175-180.
 Richard, A. (2005) Première régles: L’age de survenue en baisse chez les adolescents américains. Journal of Pediatrics, 147, 753-760.
 Kotsopoulos, J., Lubinsky, J., Lynch, H.T., et al. (2005) Age at Menarche and the Risk of Breast Cancer in BRCA1 and BRCA2 Mutation Carriers. Cancer Causes Control, 16, 667-674. http://dx.doi.org/10.1007/s10552-005-1724-1
 Hunter, D.J., Spiegelman, D., Adami, H.O., et al. (1997) Non-Dietary Factors as Risk Factors for Breast Cancer and as Effect Modifiers of the Association of Fat Intake and Risk of Breast Cancer. Cancer Causes Control, 8, 49-56.
 Clavel-Chapelon, F. (2002) Cumulative Number of Menstrual Cycles and Breast Cancer Risk: Results from the E3N Cohort Study of French Women. Cancer Causes Control, 13, 831-838. http://dx.doi.org/10.1023/A:1020684821837
 Key, T.J., Verkasalo, P.K. and Banks, E. (2001) Epidemiology of Breast Cancer. Lancet Oncology, 2, 133-140.
 Collaborative Group on Hormonal Factors in Breast Cancer (1997) Breast Cancer and Hormonal Replacement Therapy: Collaborative Reanalysis of Individual Data from 51 Epidemiological Studies of 52.705 Women with Breast Cancer and 108.411 Women without Breast Cancer. Lancet, 350, 1047-1059.
 Collaborative Groups on Hormonal Factors in Breast Cancer (1996) Breast Cancer and Hormonal Contraceptives: Collaborative Reanalysis of Individual Data on 53.297 Women with Breast Cancer and 100.239 Women without Breast Cancer from 54 Epidemiological Studies. Lancet, 347, 1713-1727.
 Liu, Q., Wuu, J., Lambe, M., Hsieh, S.F., Ekbom, A. and Hsieh, C.C. (2002) Transient Increase in Breast Cancer Risk after Giving Birth: Postpartum Period with the Highest Risk (Sweden). Cancer Causes Control, 13, 299-305.
 Merviel, P., Jouvance, O., Naepels, P., Fauvet, R., Cabry-Goubet, R., Gagneur, O. and Gondry, J. (2011) Existe-t-il encore des facteurs de risque de survenue d’un cancer du sein? Gynécologie Obstétrique & Fertilité, 39, 486-490.
 Hinkula, M., Pukkala, E., Kyyronen, P. and Kauppila, A. (2001) Grand Multiparity and the Risk of Breast Cancer: Population-Based Study in Finland. Cancer Causes Control, 12, 491-500.
 Russo, J., Hu, Y.F., Yang, X. and Russo, I.H. (2000) Developmental, Cellular, and Molecular Basis of Human Breast Cancer. Journal of the National Cancer Institute Monographs, 27, 17-37.
 Ewertz, M., Duffy, S.W., Adami, H.O., Kv?le, G., Lund, E., Meirik, O., et al. (1990) Age at First Birth Parity and Risk of Breast Cancer: A Meta-Analysis of 8 Studies from Nordic Countries. International Journal of Cancer, 46, 597-603.