JBBS  Vol.4 No.12 , December 2014
Effects of Post-Training Blockade of GABAB Receptor on Memory of Food Location and Expression of Synapsin I in the Hippocampus of Pigeons (Columba livia)
Abstract: This study investigated effects of post-training treatment with phaclofen, GABAB receptor antagonist, on the memory of food location and on the expression of Synapsin I in the hippocampus of pigeons. Pigeons were trained in food location (7 sessions) and underwent post-training treatment with phaclofen (0.3 mg/kg, i.p.; PHAC), saline (SAL) or non-treated (NTR). Testing for memory persistence occurred 7 days after the last training session (PHACR, SALR and NTRR Groups). Pigeons treated with phaclofen had lower latency and higher correct choice values than saline and non-treated controls (p < 0.05). Analysis of hippocampus tissue indicated that Synapsin I-positive cell counts were higher in pigeons treated with phaclofen than in saline and non-treated controls (p < 0.05). Data indicated enhancement of consolidation and persistence of food location memory, and up-regulation of Synapsin I expression in the hippocampus of pigeons, which were related with post-training blockade of GABAB receptors.
Cite this paper: Canova, F. , Faria, R. and de Moraes Ferrari, E. (2014) Effects of Post-Training Blockade of GABAB Receptor on Memory of Food Location and Expression of Synapsin I in the Hippocampus of Pigeons (Columba livia). Journal of Behavioral and Brain Science, 4, 579-589. doi: 10.4236/jbbs.2014.412055.

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