OJEMD  Vol.4 No.12 , December 2014
F1 Offspring of (F0) Female Rats Fed a High-Saturated Fat, Prenatal/Lactation Diet Remain Insulin Resistant Despite Postnatal Diet Rich in Omega-3 Polyunsaturated Fatty Acids
Abstract: Prior research has shown adult diets rich in omega-3 long-chain polyunsaturated fatty acids (omega-3 LC-PUFAs) can improve adult metabolic health. Previous studies have also shown maternal overnutrition during pregnancy/lactation adversely affects metabolic functioning in adult offspring. The purpose of the current study was to investigate the interaction of these two metabolism regulating factors by assessing the effectiveness of a postweaning diet rich in omega-3 long chain-polyunsaturated fatty acids (omega-3 LC-PUFAs) to improve metabolic function in adult offspring whose mothers were fed a high-saturated fat “Western” diet during pregnancy/lactation. We compared metabolic function between offspring of three prenatal-lactation/postweaning diet lines of Sprague-Dawley rats: 1) offspring of mothers fed a high-saturated fat “Western” diet during pregnancy-lactation, then weaned to a high omega-3 LC-PUFA diet (Western/PUFA); 2) offspring of mothers fed a control diet during pregnancy-lactation, then weaned to a high omega-3 LC-PUFA diet (Control/PUFA); and 3) offspring of mothers fed a Western diet during pregnancylactation, and postweaning (Western/Western). Fasting plasma insulin, triglycerides, and insulin resistance (HOMA-IR) of Western/PUFA animals were intermediate to those of Western/Western and Control/PUFA offspring, although these differences did not reach statistical significance. This suggests the metabolic benefits of an omega-3 LC-PUFA-rich diet are insufficient to overcome the deleterious effects of a high-saturated fat prenatal-lactation diet.
Cite this paper: Kachinski, J. , Jin, H. and Benyshek, D. (2014) F1 Offspring of (F0) Female Rats Fed a High-Saturated Fat, Prenatal/Lactation Diet Remain Insulin Resistant Despite Postnatal Diet Rich in Omega-3 Polyunsaturated Fatty Acids. Open Journal of Endocrine and Metabolic Diseases, 4, 258-264. doi: 10.4236/ojemd.2014.412027.

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