IJOC  Vol.4 No.5 , December 2014
The First Synthesis of Sessiline
ABSTRACT
Sessiline is an alkaloid which is recently isolated from the fruits of Acanthopanax sessiliflorus. The molecule contains two five-membered heterocyclic units joined together by an acylaminocarbinol-ether type bond. Here, we describe the first, simple synthesis of sessiline from 5-hydroxypyrrolidin-2-one and 5-hydroxymethylfurfural, which are prepared from succinimide and furfuryl alcohol, respectively. The coupling reaction takes place on moderate heating under neat conditions.

Cite this paper
Ilkei, V. , Faragó, K. , Sánta, Z. , Dékány, M. , Hazai, L. , Szántay Jr., C. , Szántay, C. and Kalaus, G. (2014) The First Synthesis of Sessiline. International Journal of Organic Chemistry, 4, 309-313. doi: 10.4236/ijoc.2014.45033.
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