CRCM  Vol.3 No.12 , December 2014
Successful Tacrolimus Therapy Extended by Everolimus in Retroperitoneal Angiomyolipoma after Lung Transplantation: A Case Report
ABSTRACT
Lymphangioleiomyomatosis (LAM) is a rare disease that affects women, especially in child-bearing age. Clinical manifestations include angiomyolipoma, pneumothorax, chylothorax, cystic changes of lungs and progressive pulmonary failure. In this article, we report a case of lung transplantation (LuTX) for end stage pulmonary LAM and the treatment of angiomyolipoma showing growth after LuTX resulting in complete remission with combination therapy of everolimus and tacrolimus.

Cite this paper
Erdélyi, T. , Bohács, A. , Vincze, K. , Kováts, Z. , Sárosi, V. , Sinkovicz, A. , Balázs, G. and Müller, V. (2014) Successful Tacrolimus Therapy Extended by Everolimus in Retroperitoneal Angiomyolipoma after Lung Transplantation: A Case Report. Case Reports in Clinical Medicine, 3, 636-638. doi: 10.4236/crcm.2014.312135.
References
[1]   Glasgow, C.G., EL-Chemaly, S. and Moss, J. (2012) Lymphatics in Lymphangioleiomyomatosis and Idiopathic Pulmonary Fibrosis. European Respiratory Review: An Official Journal of the European Respiratory Society, 21, 196-206.
http://dx.doi.org/10.1183/09059180.00009311

[2]   Johnson, S.R. (2006) Lymphangioleiomyomatosis. The European Respiratory Journal, 27, 1056-1065.

[3]   Casanova, A. and Ancochea, J. (2011) Lymphangioleiomyomatosis: New Therapeutic Approaches. Archivos de Bronconeumologia, 47, 579-580.
http://dx.doi.org/10.1016/j.arbres.2011.06.008

[4]   Henske, E.P. and McCormack, F.X. (2012) Lymphangioleiomyomatosis—A Wolfinsheep’s Clothing. The Journal of Clinical Investigation, 122, 3807-3816.
http://dx.doi.org/10.1172/JCI58709

[5]   Kpodonu, J., Massad, M.G., Chaer, R.A., et al. (2005) The US Experience with Lung Transplantation for Pulmonary Lymphangioleyomiomatosis. The Journal of Heart and Lung Transplantation: The Official Publication of the International Society for Heart Transplantation, 24, 1247-1253.
http://dx.doi.org/10.1016/j.healun.2004.09.013

[6]   Bissler, J.J., McCormack, F.X., Young, L.R., et al. (2008) Sirolimus for Angiomyolipoma in Tuberous Sclerosis Complex or Lymphangioleiomyomatosis. The New England Journal of Medicine, 358, 140-151.
http://dx.doi.org/10.1056/NEJMoa063564

[7]   Bujalance-Cabrera, C., Vaquero-Barrios, J.M. and Redel-Montero, J. (2012) Reduction in Size of Renal Angiomyolipoma after Treatment with Everolimus in Lung Transplantation Due to Lymphangioleiomyomatosis. Archivos de Bronconeumologia, 48, 479-481.
http://dx.doi.org/10.1016/j.arbres.2012.02.002

 
 
Top