Jacqueline C. Dominguez, Jennifer Rose Soriano, Cely D. Magpantay, Mary Grace S. Orquiza, Wynette Marie Solis, Macario F. Reandelar Jr., Ma. Lourdes C. Joson

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Memory Center, Institute for Neurosciences, St. Luke’s Medical Center, Quezon City, Philippines.
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Abstract: Background: The Montreal Cognitive Assessment (MoCA) is a useful instrument employed by clinicians to detect cognitive impairment and diagnose probable Alzheimer’s Disease (AD) while in its early stages. Methods: A cross-sectional study was conducted to determine the diagnostic validity of the Philippine version of the MoCA (MoCA-P) among 1385 community-dwelling Filipino elderly from Marikina City, Metro Manila. Results: 509 controls and 97 elderly with probable AD and a Clinical Dementia Rating (CDR) global score of 0.5 were included in the analysis. Analysis of variance showed that the AD group was older (p < 0.05) and had fewer years of education (p < 0.05). The optimal cut-off score to differentiate controls from those with probable AD was 20/21, with a sensitivity of 0.835 and a specificity of 0.723, and area under the curve (AUC) of 0.89 (p < 0.001). The positive and negative likelihood ratios were 3.01 and 0.23, respectively; and pre- and post-test odds were 0.0951 and 0.2224, respectively. Logistic regression showed that the odds of scoring < 20 on the MoCA-P increased with advancing age and with education at ≤7 years (p < 0.05). Two points are added to the MoCA-P score for those with ≤7 years of education. Conclusion: The MoCA-P is a valid instrument for the early detection of mild AD among the Filipino elderly.

Keywords: Alzheimer Disease, Filipino, MoCA-P, Validation

Cite this paper: Dominguez, J. , Soriano, J. , Magpantay, C. , Orquiza, M. , Solis, W. , Reandelar Jr., M. and Joson, M. (2014) Early Detection of Mild Alzheimer’s Disease in Filipino Elderly: Validation of the Montreal Cognitive Assessment-Philippines (MoCA-P). Advances in Alzheimer's Disease, 3, 160-167. doi: 10.4236/aad.2014.34015.

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