OJAP  Vol.3 No.4 , December 2014
Prenatal Exposure to Polycyclic Aromatic Hydrocarbons and Birth Weight in China
Abstract: Adverse birth outcomes are a leading cause of mortality in children in China, but the environmental influences of these conditions remain largely unexplained in this population. We aimed to evaluate the levels of polycyclic aromatic hydrocarbons (PAHs) in Chinese pregnant women and their newborns, and to examine the association between levels of PAHs and infant birth weight. We conducted a cross-sectional study including 81 pairs of mothers and newborns from four hospitals in four different cities in China. High Performance Liquid Chromatography was used to measure the concentration of nine PAHs in maternal and cord blood and multiple linear regression analyses were used to evaluate the associations of these PAHs with infant birth weight. Anthracene (ANT) had the highest average concentration and detection rate (geometric mean = 69.54 ng/g and 76.5%, respectively) in maternal serum samples, while fluoranthene (FLT) had the highest concentration and detection rate (geometric mean = 68.4 ng/g and 50.6%, respectively) in the cord blood. Most of the measured PAHs in maternal serum and three PAHs in cord blood were inversely but non-significantly associated with birth weight. The strongest associations were observed for higher concentrations of benzo (a) pyrene (BaP) in maternal serum (230.7 g decrease for levels > median vs. < LOD; p = 0.151) and for ANT in cord blood (153.1 g decrease for levels < median vs. < LOD; p = 0.208). Ant and FLT were the predominant PAHs in the maternal and cord blood serum. Serum concentrations of several measured PAHs were associated with a decreased birth weight, although not significantly, suggesting that further studies with larger sample sizes are needed to validate our findings.
Cite this paper: Chen, Q. , Zheng, T. , Bassig, B. , Cheng, Y. , Leaderer, B. , Lin, S. , Holford, T. , Qiu, J. , Zhang, Y. , Shi, K. , Zhu, Y. , Niu, J. , Li, Y. , Guo, H. , Hu, X. and Jin, Y. (2014) Prenatal Exposure to Polycyclic Aromatic Hydrocarbons and Birth Weight in China. Open Journal of Air Pollution, 3, 100-110. doi: 10.4236/ojap.2014.34010.

[1]   Bostrom, C.E., Gerde, P., Hanberg, A., Jernstrom, B., Johansson, C., Kyrklund, T., et al. (2002) Cancer Risk Assessment, Indicators, and Guidelines for Polycyclic Aromatic Hydrocarbons in the Ambient Air. Environmental Health Perspectives, 110, 451-488.

[2]   Perera, F.P., Rauh, V., Tsai, W.Y., Kinney, P., Camann, D., Barr, D., et al. (2003) Effects of Transplacental Exposure to Environmental Pollutants on Birth Outcomes in a Multiethnic Population. Environmental Health Perspectives, 111, 201-205.

[3]   Shen, H., Huang, Y., Wang, R., Zhu, D., Li, W., Shen, G., et al. (2013) Global Atmospheric Emissions of Polycyclic Aromatic Hydrocarbons from 1960 to 2008 and Future Predictions. Environmental Science & Technology, 47, 6415-6424.

[4]   Liu, S., Tao, S., Liu, W., Liu, Y., Dou, H., Zhao, J., et al. (2007) Atmospheric Polycyclic Aromatic Hydrocarbons in North China: A Winter-Time Study. Environmental Science & Technology, 41, 8256-8261.

[5]   Zhang, S., Zhang, W., Wang, K., Shen, Y., Hu, L. and Wang, X. (2009) Concentration, Distribution and Source Apportionment of Atmospheric Polycyclic Aromatic Hydrocarbons in the Southeast Suburb of Beijing, China. Environmental Monitoring and Assessment, 151, 197-207.

[6]   Mathews, T.J. and MacDorman, M.F. (2008) Infant Mortality Statistics from the 2005 Period Linked Birth/Infant Death Data Set. National Vital Statistics Reports: From the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System, 57, 1-32.

[7]   Feng, J., Yuan, X.Q., Zhu, J., Li, X.H., Miao, L., He, C.H., et al. (2012) Under-5-Mortality Rate and Causes of Death in China, 2000 to 2010. Zhonghua Liu Xing Bing Xue Za Zhi, 33, 558-561.

[8]   Wang, J.Z., Zhu, C.Z. and Chen, T.H. (2013) PAHs in the Chinese Environment: Levels, Inventory Mass, Source and Toxic Potency Assessment. Environmental Science Processes & Impacts, 15, 1104-1112.

[9]   Choi, H., Rauh, V., Garfinkel, R., Tu, Y. and Perera, F.P. (2008) Prenatal Exposure to Airborne Polycyclic Aromatic Hydrocarbons and Risk of Intrauterine Growth Restriction. Environmental Health Perspectives, 116, 658-665.

[10]   Choi, H., Jedrychowski, W., Spengler, J., Camann, D.E., Whyatt, R.M., Rauh, V., et al. (2006) International Studies of Prenatal Exposure to Polycyclic Aromatic Hydrocarbons and Fetal Growth. Environmental Health Perspectives, 114, 1744-1750.

[11]   Perera, F.P., Whyatt, R.M., Jedrychowski, W., Rauh, V., Manchester, D., Santella, R.M., et al. (1998) Recent Developments in Molecular Epidemiology: A Study of the Effects of Environmental Polycyclic Aromatic Hydrocarbons on Birth Outcomes in Poland. American Journal of Epidemiology, 147, 309-314.

[12]   Perera, F.P., Tang, D.L., Rauh, V., Lester, K., Tsai, W.Y., Tu, Y.H., et al. (2005) Relationships among Polycyclic Aromatic Hydrocarbon-DNA Adducts, Proximity to the World Trade Center, and Effects on Fetal Growth. Environmental Health Perspectives, 113, 1062-1067.

[13]   Tsang, H.L., Wu, S.C., Leung, C.K., Tao, S. and Wong, M.H. (2011) Body Burden of POPs of Hong Kong Residents, Based on Human Milk, Maternal and Cord Serum. Environment International, 37, 142-151.

[14]   Guo, Y.Y., Huo, X., Wu, K.S., Liu, J.X., Zhang, Y.L. and Xu, X.J. (2012) Carcinogenic Polycyclic Aromatic Hydrocarbons in Umbilical Cord Blood of Human Neonates from Guiyu, China. The Science of the Total Environment, 427-428, 35-40.

[15]   Yu, Y.X., Wang, X.L., Wang, B., Tao, S., Liu, W.X., Wang, X.J., et al. (2011) Polycyclic Aromatic Hydrocarbon Residues in Human Milk, Placenta, and Umbilical Cord Blood in Beijing, China. Environmental Science & Technology, 45, 10235-10242.

[16]   Dong, S., Ding, C., Zhang, M. and Liu, Y. (2009) Relationship of PAHs Levels in Umbilical Cord Blood and the PAHs Exposure between the Mother and the Paired Newborns. Journal of Hygiene Research, 38, 339-342.

[17]   Tang, D.L., Li, T.Y., Liu, J.J., Chen, Y.H., Qu, L.R. and Perera, F. (2006) PAH-DNA Adducts in Cord Blood and Fetal and Child Development in a Chinese Cohort. Environmental Health Perspectives, 114, 1297-1300.

[18]   Tang, D.L., Li, T.Y., Chow, J.C., Kulkarni, S.U., Watson, J.G., Ho, S.S., et al. (2014) Air Pollution Effects on Fetal and Child Development: A Cohort Comparison in China. Environmental Pollution, 185, 90-96.

[19]   Ding, C., Zheng, L. and Lin, S. (2012) Determination of Nine Kinds of Polycyclic Aromatic Hydrocarbons in Serum by High Performance Liquid Chromatography. Journal of Hygiene Research, 41, 850-853.

[20]   Rylander, L., Nilsson-Ehle, P. and Hagmar, L. (2006) A Simplified Precise Method for Adjusting Serum Levels of Persistent Organohalogen Pollutants to Total Serum Lipids. Chemosphere, 62, 333-336.

[21]   The International Agency for Research on Cancer (1983) Polynuclear Aromatic Compounds, Part 1, Chemical, Environmental and Experimental Data. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, 32, 1-453.

[22]   WHO (2000) Air Quality Guidelines for Europe. WHO Regional Publications, European Series, No. 91, V-X, 1-273.

[23]   Dejmek, J., Solansky, I., Benes, I., Lenicek, J. and Sram, R.J. (2000) The Impact of Polycyclic Aromatic Hydrocarbons and Fine Particles on Pregnancy Outcome. Environmental Health Perspectives, 108, 1159-1164.

[24]   Zhang, D.H., Ma, Y.L., He, K.B., Duan, F.K., Jia, Y.T., Okuda, T., et al. (2006) Characteristics of Polycyclic Aromatic Hydrocarbons (PAHS) on Airborne Particulates in Beijing. Environmental Science, 27, 1269-1275.

[25]   Aarstad, K., Toftgard, R. and Nilsen, O.G. (1987) A Comparison of the Binding and Distribution of Benzo[a]Pyrene in Human and Rat Serum. Toxicology, 47, 235-245.

[26]   Madhavan, N.D. and Naidu, K.A. (1995) Polycyclic Aromatic Hydrocarbons in Placenta, Maternal Blood, Umbilical Cord Blood and Milk of Indian Women. Human & Experimental Toxicology, 14, 503-506.

[27]   Minh, T.B., Watanabe, M., Kajiwara, N., Iwata, H., Takahashi, S., Subramanian, A., et al. (2006) Human Blood Monitoring Program in Japan: Contamination and Bioaccumulation of Persistent Organochlorines in Japanese Residents. Archives of Environmental Contamination and Toxicology, 51, 296-313.

[28]   Anderson, L.M., Jones, A.B., Miller, M.S. and Chauhan, D.P. (1989) Metabolism of Transplacental Carcinogens. IARC Scientific Publications, 96, 155-188.

[29]   Jedrychowski, W., Perera, F.P., Tang, D.L., Stigter, L., Mroz, E., Flak, E., et al. (2012) Impact of Barbecued Meat Consumed in Pregnancy on Birth Outcomes Accounting for Personal Prenatal Exposure to Airborne Polycyclic Aromatic Hydrocarbons: Birth Cohort Study in Poland. Nutrition, 28, 372-377.

[30]   Choi, H., Wang, L., Lin, X.H., Spengler, J.D. and Perera, F.P. (2012) Fetal Window of Vulnerability to Airborne Polycyclic Aromatic Hydrocarbons on Proportional Intrauterine Growth Restriction. PLoS ONE, 7, e35464.