Enhancing Population’s Resistance to Toxic Exposures as an Auxilliary Tool of Decreasing Environmental and Occupational Health Risks (a Self-Overview)

Julia I.  Soloboyeva; Sergey V.  Yarushin; Nadezhda V.  Loginova; Marina P.  Sutunkova; Ilzira A.  Minigalieva; Ekaterina P.  Kireyeva; Sergey V.  Kuzmin; Vladimir B.  Gurvich; Larisa I.  Privalova; Boris A.  Katsnelson; Natalia I.  Kochneva; Olga L.  Malykh

doi:10.4236/jep.2014.514137

JEP Vol.5 No.14 , November 2014

Enhancing Population’s Resistance to Toxic Exposures as an Auxilliary Tool of Decreasing Environmental and Occupational Health Risks (a Self-Overview)

Boris A. Katsnelson¹^*, Larisa I. Privalova¹, Vladimir B. Gurvich¹, Sergey V. Kuzmin^1,2, Ekaterina P. Kireyeva¹, Ilzira A. Minigalieva¹, Marina P. Sutunkova¹, Nadezhda V. Loginova¹, Olga L. Malykh², Sergey V. Yarushin¹, Julia I. Soloboyeva¹, Natalia I. Kochneva²

Abstract: Environment chemical pollution can be persistent, and even virtually irremovable. For some chemicals in the workplace environment reliably safe low exposure levels are technically unattainable or presumably nonexistent. As a supplement to decreasing harmful exposures to as low levels as possible, the “biological prophylaxis” aims at enhancing host’s protective mechanisms. During over 30 years in animal experiments modeling isolated or combined chronic or subchronic exposures to silica, asbestos, monazite, lead, chromium, arsenic, manganese, nickel, vanadium, nanosilver, nanocopper, formaldehyde, phenol, naphthalene, benzo(a)pyrene we tested so-called “bioprophylatic complexes” (BPCs) comprising innocuous substances with theoretically expected beneficial influence on the toxicokinetics and/or toxicodynamics of those toxics. The BPCs proved protectively effective in animal experiments were then subjected to controlled field trials on restricted groups of volunteers. Once the effectiveness and safety of a BPC was established, it was recommended for practical use, first of all, in the most vulnerable population groups (children, pregnant women) and in the most harmful occupations. At each stage of this work the effectiveness of the bioprophylactic approach to chemical risks management was successfully demonstrated. The BPCs tested up to now proved capable of mitigating systemic toxicity, cytotoxicity, fibrogenicity, and mutagenicity of the above-listed chemicals.

Keywords: Environmental Pollution, Health Risks, Bio-Protectors

Cite this paper: Katsnelson, B. , Privalova, L. , Gurvich, V. , Kuzmin, S. , Kireyeva, E. , Minigalieva, I. , Sutunkova, M. , Loginova, N. , Malykh, O. , Yarushin, S. , Soloboyeva, J. and Kochneva, N. (2014) Enhancing Population’s Resistance to Toxic Exposures as an Auxilliary Tool of Decreasing Environmental and Occupational Health Risks (a Self-Overview). Journal of Environmental Protection, 5, 1435-1449. doi: 10.4236/jep.2014.514137.

References

[1] Katsnelson, B.A., Degtyareva, T.D. and Privalova, L.I. (2004) Development of Means Increasing Resistance of the Organism to the Effect of Inorganic Pollutants of Industrial and Natural Environments. Russia, Ross Khim Zh, 48, 65-71.

[2] Katsnelson, B.A., Polzik, E.V. and Privalova, L.I. (1986) Some Aspects of the Problem of Individual Predisposition to Silicosis. Environmental Health Perspectives, 68, 175-185.
http://dx.doi.org/10.1289/ehp.8668175

[3] Katsnelson, B.A., Alekseyeva, O.G., Privalova, L.I. and Polzik, E.V. (1995) Pneumoconioses: Pathogenesis and Biological Prophylaxis. Ural Division of the Russian Academy of Sciences Russia, Ekaterinburg.

[4] Polzik, E.V., Katsnelson, B.A., Kochneva, M.Yu. and Kasantsev, V.S. (1990) The Principles of Predicting the Individual Risk of Silicosis and Silicotuberculosis. Med Lav, 81, 87-95.

[5] Polzik, E.V., Katsnelson, B.A., Yakusheva, M.Yu. and Kasantsev, V.S. (1993) A Follow-Up on Workers with Predicted Individual Susceptibility to Silicosis. Med Lav, 84, 249-255.

[6] Morosova, K.I., Katsnelson, B.A., Rotenberg, Yu.S. and Belobragina, G.V. (1984) A Further Experimental Study of the Antisilicotic Effect of Glutamate. Br J Ind Med, 41, 518-525.

[7] Privalova, L.I., Katsnelson, B.A., Sutunkova, M.Р., Valamina, I.E., Beresneva, O.Yu., Degtyareva, T.D. and Yeremenko, O.S. (2007) Attenuation of Some Adverse Health Effects of Chrysotile Asbestos with a Bioprotective Complex in Animal Experiments. Cent Eur J Occup Environ Med, 13, 3-14.

[8] Katsnelson, B.A., Yeremenko, O.S., Privalova, L.I., Makeyev, O.H., Degtyareva, T.D., Beresneva, O.Y. and Nazukin, A.S. (2009) Toxicity of Monazite Particulate and Its Attenuation with a Complex of Bio-Protectors. Med Lav, 100, 455-470.

[9] Kireyeva, E.P., Katsnelson, B.A., Degtyareva, T.D., Privalova, L.I., Valamina, I.E., Beresneva, O.Yu. and Denisenko, S.A. (2006) Nephrotoxic Effect of Lead and Cadmium and Its Inhibition by a Set of Bioprotectors. (Russian). Toxicol Vest, 6, 26-32.

[10] Degtyareva, T.D., Katsnelson, B.A., Minigalieva, I.A., Soloboeva, Yu.I., Brezgina, S.V., Beresneva, O.Yu. and Makarenko, N.P. (2007) Biological Prevention of Combined Effect of Toxic Metals and Organic Substances. Russia, Gig Sanit, 3, 37-40.

[11] Katsnelson, B.A., Privalova, L.I., Kireyeva, Y.P., Yeremenko, O.S., Sutunkova, M.P., Valamina, I.E., Varaksin, A.N., Panov, V.G. and Kazmer, J.I. (2012) Combined Subchronic Fluoride-Lead Intoxication and Its Attenuation with the Help of a Complex of Bioprotectors. La Medicina del lavoro, 103, 146-159.

[12] Katsnelson, B.A., Degtyareva, T.D., Privalova, L.I., Denisenko, S.A., Beresneva, O.Yu., Soloboeva, Yu.I. and Minigalieva, I.A. (2005) Biological Prophylaxis as a Complex Influence upon an Organism Increasing Its Resistance against Exposure to Chemical Hazards of Occupation and Environment. Russia, Vestn Ural Med Akad, 2, 70-76.

[13] Katsnelson, B.A., Privalova, L.I., Gurvich, V.B., Makeyev, O.H., Shur, V.Ya., Beikin, Ya.B., Tulakina, L.G., et al. (2013) Comparative in Vivo Assessment of Some Adverse Bioeffects of Equidimensional Gold and Silver Nanoparticles and the Attenuation of Nanosilver’s Effects with a Complex of Innocuous Bioprotectors. International Journal of Molecular Sciences, 14, 2449-2483.

[14] Privalova, L.I., Katsnelson, B.A., Loginova, N.V., Gurvich, V.B., Shur, V.Y., Valamina, I.E., Kostykova, S.V., et al. (2014) Subchronic Toxicity of Copper Oxide Nanoparticles and Its Attenuation with the Help of a Combination of Bioprotectors. International Journal of Molecular Sciences, 15, 12379-12406.
http://dx.doi.org/10.3390/ijms150712379

[15] Katsnelson, B.A., Degtyareva, T.D., Privalova, L.I., Minigaliyeva, I.A., Slyshkina, T.V., Ryzhov, V.V. and Beresneva, O.Y. (2013) Attenuation of Subchronic Formaldehyde Inhalation Toxicity with Oral Administration of Glutamate, Glycine and Methionine. Toxicology Letters, 220, 181-186.
http://dx.doi.org/10.1016/j.toxlet.2013.04.024

[16] Degtyareva, T.D., Privalova, L.I., Katsnelson, B.A., Beresneva, O.Yu., Denisenko, S.F. and Bukharova, G.Sh. (2002) Estimation of the Influence of Sodium Glutamate and Saparalum on the Cytotoxic Action of Particles of Low Soluble Compounds of Some Toxic Metals. Russia, Topical Issues in Preventive Medicine in the Ural Region (Collected Research Papers), Medical Research Center of Prophylaxis, Ekaterinburg.

[17] Degtyareva, T.D., Katsnelson, B.A., Privalova, L.I., Gurvich, V.B., Denisenko, S.A., Beresneva, O.Yu. and Makarenko, N.P. (2004) An Experimental Trial of an Iron-Containing Biopreventive Complex Inhibiting the Development of Harmful Environmental Effects of Lead in Combination with Other Toxic Metals. Russia, Contemporary Issues in Preventive Medicine, Environment and Public Health in Industrial Regions of Russia, (Onishchenko, G.G., Ed.), Medical Research Center of Prophylaxis, Ekaterinburg.

[18] Degtyareva, T.D., Katsnelson, B.A., Privalova, L.I., Beresneva, O.Y., Konysheva, L.K. and Demchenko, P.I. (2000) Estimation of the Effectiveness of Biological Prevention agents Lead Intoxication (An Experimental Study). Russia, Med tr prom ekol, 3, 40-43.

[19] Katsnelson, B.A., Degtyareva, T.D. and Privalova, L.I. (1999) Principles of Biological Prevention of Occupational and Environmental Pathology Due to the Impact of Inorganic Substances. Russia, Medical Research Center of Prophylaxis, Ekaterinburg.

[20] Katsnelson, B.A., Degtyareva, T.D., Privalova, L.I., Medvedeva, S.J., Gurvich, V.B. and Denisenko, S.A. (2004) Inhibition of General Toxic and Thyreotoxic Action of a Combination of Environmental Contaminants-Metals with a Complex of Bioprotective Agents. Russia, Toxicol Vest, 2, 23-29.

[21] Katsnelson, B.A., Makeyev, O.H., Kochneva, N.I., Privalova, L.I., Degtyareva, T.D., Bukhantsev, V.A. and Dovzhenko, E.I. (2007) Testing a Set of Bioprotectors against the Genotoxic Effect of a Combination of Ecotoxicants. Central European Journal of Occupational and Environmental Medicine, 13, 251-264.

[22] Degtyareva, T.D. (2001) The Influence of Biotic Doses of Copper on the Development of Lead Intoxication in Experiment. Russia, Occupational Medicine and Industrial Ecology (Collected Research Papers), (Domnin, S.G., Ed.), Medical Research Center of Prophylaxis, Ekaterinburg.

[23] Katsnelson, B.A., Privalova, L.I., Kuzmin, S.V., Malykh, O.L., Gurvich, V.B., Voronin, S.A. and Soloboeva, Yu.I. (2008) Lead and Childhood: Risks and Their Management (the Middle Urals Experience). Central European Journal of Occupational and Environmental Medicine, 14, 3-25.

[24] Ettinger, A.E., Lamadrid-Figueroa, H., Tellez-Rojo, M.M., Mercaso-Garcia, A., Peterson, K.E., Schwartz, J., Hu, H. and Hernandez-Avila, M. (2009) Effect of Calcium Supplementation on Blood Lead Level in Pregnancy: A Randomized Placebo-Controlled Trial. Environmental Health Perspectives, 117, 26-31.
http://dx.doi.org/10.1289/ehp.11868

[25] Akhter, S., Momen, M.A., Rahman, M.M., Parveen, T. and Karim, R.K. (2010) Effect of Maternal Anemia on Fetal Outcome. Mymensingh Medical Journal, 19, 391-398.

[26] Katsnelson, B.A., Kireyeva, E.P., Kuzmin, S.V., Privalova, L.I., Burns, K.M., Khrushcheva, N.A. and Denisenko, S.A. (2007) An Association between Incipient Renal Damage and Urine Cadmium and Lead Levels in Young Russian Children: A Case Control Study. European Epi Marker, 11, 1-8.

[27] Varaksin, A.N., Katsnelson, B.A., Panov, V.G., Privalova, L.I., Kireyeva, E.P., Valamina, I.E. and Beresneva, O.Y. (2014) Some Considerations Concerning the Theory of Combined Toxicity: A Case Study of Subchronic Experimental Intoxication with Cadmium and Lead. Food and Chemical Toxicology, 64, 144-156.
http://dx.doi.org/10.1016/j.fct.2013.11.024

[28] Katsnelson, B.A., Privalova, L.I., Degtyareva, T.D., Kireyeva, E.P., Khrushcheva, N.A., Beikin, Ya.B. and Sutunkova, M.P. (2007) Correction of Certain Indices of Renal Function in Children Exposed to Lead and Cadmium as a Result of Using a Complex of Antitoxic Bioprotectors. Russia, Toxicol Vest, 6, 11-15.

[29] Katsnelson, B.A., Kochneva, N.I., Makeyev, O.H. and Privalova, L.I. (2008) Risk Factors for Cancer in a Small Russian Town with Unusually High Cancer Morbidity Rates and the Search for Biological Protection of Its Residents. Central European Journal of Occupational and Environmental Medicine, 14, 53-54.

[30] Kapiczewska, M. (2006) A Vegetable to Meat Consumption Ratio as a Relevant Factor Determining Cancer Preventive Diet. The Mediterranean versus Other European Countries. Forum of Nutrition, 59, 130-157.
http://dx.doi.org/10.1159/000095211

[31] Jedrychowski, W. and Maugeri, U. (2008) An Apple a Day May Hold Colorectal Cancer at Bay. A Recent Evidence from Case-Control Study. European Epi Marker, 12, 1-8.

[32] Sugimura, T. (2002) Food and Cancer. Toxicology, 181-182, 17-21.
http://dx.doi.org/10.1016/S0300-483X(02)00250-0

[33] Katsnelson, B.A., Makeyev, O.G., Kochneva, N.I., Degtyareva, T.D., Privalova, L.I., Beresneva, O.Yu. and Kireyeva, E.P. (2008) A Controlled Trial on Female Volunteers of a Set of Biological Protectors against Environmentally Caused Toxic and Carcinogenic Risk. Russia, Toxicol Vest, 3, 12-19.