Laura E. Gayosso-García Sancho¹, Elhadi M. Yahia², Pablo García-Solís³, Gustavo A. González-Aguilar⁴

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¹ Jefatura de Nutrición Humana, Universidad Estatal de Sonora, Hermosillo, México.
² Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Querétaro, México.
³ Facultad de Medicina, Universidad Autónoma de Querétaro, Querétaro, México.
⁴ Coordinación de Tecnología de Alimentos de Origen Vegetal, Centro de Investigación en Alimentación y Desarrollo, A.C., Hermosillo, México.
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Abstract: Several epidemiological studies have suggested that carotenoids have antineoplasic activities. The objective of this study was to determine the antiproliferative effect of rich carotenoid lipophilic extracts of papaya fruit pulp ( Carica papaya L., cv Maradol) in breast cancer cells, MCF-7 (estrogen receptor positive) and MDA-MB-231 (estrogen receptor negative), and in non-tumoral mammary epithelial cells MCF-12F. Antiproliferative effect was evaluated using the methylthiazolydiphenyl-tetrazolium bromide (MTT) assay and testing lipophilic extracts from different papaya fruit ripening stages (RS1, RS2, RS3, RS4), at different times (24, 48 and 72 h). Papaya lipophilic extracts do not inhibit cell proliferation of MCF-12F and MDA-MB-231 cells. However, MCF-7 cells showed a significant reduction in proliferation at 72 h with the RS4 papaya extract. Results suggested that lipophilic extracts had different action mechanisms on each type of cells and therefore, more studies were required to elucidate such mechanisms.

Keywords: Carica papaya, Antiproliferative Activity, Breast Cancer, Carotenoids

Cite this paper: Sancho, L. , Yahia, E. , García-Solís, P. and González-Aguilar, G. (2014) Inhibition of Proliferation of Breast Cancer Cells MCF7 and MDA-MB-231 by Lipophilic Extracts of Papaya (Carica papaya L. var. Maradol) Fruit. Food and Nutrition Sciences, 5, 2097-2103. doi: 10.4236/fns.2014.521222.

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