OJOph  Vol.4 No.4 , November 2014
Xeroderma Pigmentosa: High Risk for Ocular Neoplasia
Abstract: Aim of Work: The aim of our work was early cytological and laboratory detection of any ocular surface malignant changes in xeroderma pigmentosa. Patients and Methods: Eighteen cases with xeroderma pigmentosa were included in this study. All cases were subjected to full ophthalmolog-ical examination, conjunctival biopsy from any abnormal lesion, polymerase chain reaction assay and impression cytology. Results: All cases were boys; the mean age was 11 years old. The main ocular presentation was dryness and abnormal epibulbar masses in different locations. Polymerase chain reaction represents precipitation of malignant cells which was confirmed by impression cytology. Conclusion: PCR and impression cytology are beneficial investigations for detection of any malignant changes in xeroderma pigmentosa.
Cite this paper: Elawamry, A. , El-Moatassem Kotb, A. and Hany, S. (2014) Xeroderma Pigmentosa: High Risk for Ocular Neoplasia. Open Journal of Ophthalmology, 4, 120-123. doi: 10.4236/ojoph.2014.44020.

[1]   Ghobrial, F.G. (2005) Conjunctival Squamous Cell Carcinoma in Xeroderma PIgmentosum Case Report. Egyptian Bullitien of Opthalmology, 98, 18.

[2]   Tseng, S.C.G. (1985) Staging of Conjunctival Squamous Metaplasiil by Impression Cytology. Ophthalmology, 92, 728-733.

[3]   Ferrer, C., Colom, F., Frases, S., Mulet, E., Abad, J.L. and Alio, J.L. (2001) Detection and Identification of Fungal Pathogens by PCR and by ITS2 and 58s Ribosomal DNA Typing in Ocular Infections. Journal of Clinical Microbiology, 39, 2873-2879.

[4]   Lohamann, C.P., Linde, H.I. and Reisehl, U. (2000) Improved Detection of Microorganisms by Polymerase Chain Reaction in Delayed Endophthalmitis after Cataract Surgery. Ophthalmology, 107, 1047-1052.

[5]   Goyal, J., Rao, V., Srinivasan, R. and Agarawal, K. (1994) Oculocutaneuos Manifestations in Xeroderma Pigmentosum. British Journal of Ophthalmology, 78, 295-297.

[6]   Babar, T.F., Khan, M.N., Hussain, M., Shah, S.A., Khan, M.Y. and Khan, M.D. (2007) Spectrum of Ocular Surface Squamous Neoplasia. Journal of the College of Physicians and Surgeons Pakistan, 17, 344-346.