Sadegh Chinikar^1*, Abbas Ali Javadi^2*, Arash Hajiannia², Behroz Ataei², Tahmineh Jalali¹, Sahar Khakifirouz¹, Norbert Nowotny^3,4, Jonas Schmidt-Chanasit⁵, Nariman Shahhosseini^1,5

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¹ Arboviruses and Viral Haemorrhagic Fevers Laboratory (National Ref. Lab), Department of Virology, Pasteur Institute of Iran, Tehran, Iran.
² Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
³ Institute of Virology, University of Veterinary Medicine, Vienna, Austria.
⁴ Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
⁵ WHO Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research, Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
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Abstract: Hantavirus is a zoonosis transmitted from rodents to humans. Asymptomatic infected rodents can secrete hantaviruses in the urine, feces, and saliva. The main route of infection transmission to human is aerosols contaminated with the virus. This study was designed to evaluate the serological and molecular prevalence of hantavirus as an emerging zoonoses disease among street sweepers in Isfahan province, central Iran. Serum samples from 200 street sweepers in healthy condition and those with recent renal failure were tested by ELISA (IgM and IgG). Molecular analysis was subsequently applied for IgM positive cases. From these samples, 9 (4.5%) were positive, of which 2 (22.22%) were positive for both IgM and RT-PCR, while 7 (77.77%) were positive for IgG. The mean age and work experience of the positive cases were 39.7 and 11.5 respectively. According to our observations, all positive cases reported prevalence of rodents in their work place. The logistic regression test showed that the age and work experience were not risk factors for being positive, but prevalence of rodents in work place was a risk factor for being positive, when compared with negative cases. This is the first comprehensive study on the prevalence of hantavirus with positive results coming from Iranian population, which can raise the public awareness for the hantavirus infections as a public health threat.

Keywords: Hantavirus, Emergence Zoonoses, Rodent, Arboviruses, Iran

Cite this paper: Chinikar, S. , Javadi, A. , Hajiannia, A. , Ataei, B. , Jalali, T. , Khakifirouz, S. , Nowotny, N. , Schmidt-Chanasit, J. , Shahhosseini, N. (2014) First Evidence of Hantavirus in Central Iran as an Emerging Viral Disease. Advances in Infectious Diseases, 4, 173-177. doi: 10.4236/aid.2014.44024.

References

[1]   Peters, C. and Khan, A.S. (2002) Hantavirus Pulmonary Syndrome: The New American Hemorrhagic Fever. Clinical Infectious Diseases, 34, 1224-1231. http://dx.doi.org/10.1086/339864

[2]   Schmaljohn, C. and Hjelle, B. (1997) Hantaviruses: A Global Disease Problem. Emerging Infectious Diseases, 3, 95-104. http://dx.doi.org/10.3201/eid0302.970202

[3]   Clement, J.P. (2003) Hantavirus. Antiviral Research, 57, 121-127.
http://dx.doi.org/10.1016/S0166-3542(02)00205-X

[4]   Sarigüzel, N., Hofmann, J., Canpolat, A.T., et al. (2012) Dobrava Hantavirus Infection Complicated by Panhypopituitarism, Istanbul, Turkey, 2010. Emerging Infectious Diseases, 18, 1180-1183.
http://dx.doi.org/10.3201/eid1807.111746

[5]   Jonsson, C.B., Figueiredo, L.T.M. and Vapalahti, O. (2010) A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease. Clinical Microbiology Reviews, 23, 412-441.
http://dx.doi.org/10.1128/CMR.00062-09

[6]   Frey, M.T., Vial, P.C., Castillo, C.H., et al. (2003) Hantavirus Prevalence in the IX Region of Chile. Emerging Infectious Diseases, 9, 827-832. http://dx.doi.org/10.3201/eid0907.020587

[7]   Jay, M., Ascher, M.S., Chomel, B.B., et al. (1997) Seroepidemiologic Studies of Hantavirus Infection among Wild Rodents in California. Emerging Infectious Diseases, 3, 183-190.
http://dx.doi.org/10.3201/eid0302.970213

[8]   Kallio, E.R., Klingström, J., Gustafsson, E., et al. (2006) Prolonged Survival of Puumala Hantavirus Outside the Host: Evidence for Indirect Transmission via the Environment. Journal of General Virology, 87, 2127-2134. http://dx.doi.org/10.1099/vir.0.81643-0

[9]   Chinikar, S., Shayesteh, M., Khakifirouz, S., et al. (2013) Nosocomial Infection of Crimean-Congo Haemorrhagic Fever in Eastern Iran: Case Report. Travel Medicine and Infectious Disease, 11, 252-255. http://dx.doi.org/10.1016/j.tmaid.2012.11.009

[10]   Chinikar, S., Shah-Hosseini, N., Bouzari, S., et al. (2013) New Circulating Genomic Variant of Crimean-Congo Hemorrhagic Fever Virus in Iran, Archives of Virology, 158, 1085-1088.
http://dx.doi.org/10.1007/s00705-012-1588-0

[11]   Chinikar, S., Ghiasi, S. M., Shah-Hosseini, N., et al. (2013) Preliminary Study of Dengue Virus Infection in Iran. Travel Medicine and Infectious Disease, 11, 166-169.
http://dx.doi.org/10.1016/j.tmaid.2012.10.001

[12]   Chinikar, S., Shah-Hosseini, N., Mostafavi, E., et al. (2013) Seroprevalence of West Nile Virus in Iran. Vector-Borne and Zoonotic Diseases, 13, 586-589. http://dx.doi.org/10.1089/vbz.2012.1207

[13]   Chinikar, S., Shah-Hosseini, N., Mostafavi, E., Jalali, T. and Fooks, A.R. (2013) Surveillance of Rift Valley Fever in Iran between 2001 and 2011. All Results Journals, 4, 16-18.

[14]   Rovida, F., Percivalle, E., Sarasini, A., Chichino, G. and Baldanti, F. (2013) Imported Hantavirus Cardiopulmonary Syndrome in an Italian Traveller Returning from Cuba. The New Microbiologica, 36, 103-105.

[15]   Oncul, O., Atalay, Y., Onem, Y., et al. (2011) Hantavirus Infection in Istanbul, Turkey. Emerging Infectious Diseases, 17, 303-304. http://dx.doi.org/10.3201/eid1702.100663

[16]   Escadafal, C., Avsic-Zupanc, T., Vapalahti, O., et al. (2012) Second External Quality Assurance Study for the Serological Diagnosis of Hantaviruses in Europe. PLoS Neglected Tropical Diseases, 6, e1607.

[17]   Hofmann, J., Meisel, H., Klempa, B., et al. (2008) Hantavirus Outbreak, Germany, 2007. Emerging Infectious Diseases, 14, 850-852. http://dx.doi.org/10.3201/eid1405.071533

[18]   Heyman, P., Cochez, C., Korukluoglu, G., et al. (2011) Bridging Continents: Hantaviruses of Europe and Asia Minor. Türk Hijyen ve Deneysel Biyoloji Dergisi, 68, 41-48.
http://dx.doi.org/10.5505/TurkHijyen.2011.33254

[19]   Gozalan, A., Kalaycioglu, H., Uyar, Y., et al. (2013) Human Puumala and Dobrava Hantavirus Infections in the Black Sea Region of Turkey: A Cross-Sectional Study. Vector-Borne and Zoonotic Diseases, 13, 111-118. http://dx.doi.org/10.1089/vbz.2011.0939