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 JCDSA  Vol.4 No.5 , December 2014
In Vitro Evaluations for a New Topical Anti-Aging Formulation
Abstract: The study aimed to evaluate the in vitro properties of a new gel formulation (P-3086) as anti-aging treatment. Two in vitro methods aimed to assess and compare the efficacy of the gel formulation in reducing oxidative damages, artificially induced by UVA on skin-derived keratinocytes and in promoting the synthesis of collagen, compared with other four formulations. P-3086 reduced reactive oxygen species production after UVA stress with the highest effect observed at 0.016 mg/ml and 0.031 mg/ml concentration. P-3086 also promoted the collagen synthesis faster when compared with other formulations. The new gel product, based on hyaluronic acid, Vitamin E and Humulus lupulus, showed a good efficacy as anti-aging effect reducing the oxidative damages derived by the action of ROS, moreover stimulating the synthesis of one of the components of the connective tissue, the collagen.
Cite this paper: Scarci, F. and Mailland, F. (2014) In Vitro Evaluations for a New Topical Anti-Aging Formulation. Journal of Cosmetics, Dermatological Sciences and Applications, 4, 316-322. doi: 10.4236/jcdsa.2014.45041.
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