Health  Vol.6 No.19 , November 2014
The Effect of Tea-Cinnamon and Melissa officinalis L. Aqueous Extraction, on Neuropsychology Distress, Biochemical and Oxidative Stress Biomarkers in Glass Production Workers
ABSTRACT
Medicinal plants are considered as natural sources of antioxidant compounds which may protect organisms against oxidative stresses. The aim of this study was to evaluate the potential of Cinnamon and Melissa officinalis L. (Lemon balm) on the improvement of oxidative stress in glass production workers. This clinical study was conducted on 32 glass production workers. They were asked to use 0.5 g of tea-Cinnamon and 3 g of Lemon balm as infusion for 30 days in the morning and evening each day. At the beginning and the end of the study, blood samples were taken from individuals to determine the level of fasting blood suger (FBS), aspartate transaminase (AST), alanintransferase (ALT), triglyceride (TG), cholesterol (CL), low-density lipoprotein (LDL), high-density lipoprotein(HDL) levels, lipid peroxidation (LPO), total antioxidant capacity (TAC) and sillies were measured in workers’ blood. At the end of experiment, data were subjected to the paired t-test analysis. Clinical examination was accomplished to record any abnormal signs or symptoms. After treatment, the high-density lipoprotein and TAC of serum significantly increased while the AST and LPO decreased. There were positive correlations between work history and initiative energy disorder of cognitive test. Probably tea-Cinnamon and Lemon balm possesses marked antioxidant activity and, therefore, it can be used to protect individuals from the oxidative stresses. Using supplementary antioxidants may be helpful in the treatment of workers.

Cite this paper
Rashidi, M. , Malekirad, A. , Abdollahi, M. , Habibollahi, S. , Dolatyari, N. and Narimani, M. (2014) The Effect of Tea-Cinnamon and Melissa officinalis L. Aqueous Extraction, on Neuropsychology Distress, Biochemical and Oxidative Stress Biomarkers in Glass Production Workers. Health, 6, 2592-2601. doi: 10.4236/health.2014.619298.
References
[1]   Maciejewska, A. (2007) Backgrounds for Assessing Occupational Exposure to Crystalline Silica Dust in Poland and Worldwide. Medycyna Pracy, 58, 327-344.

[2]   Miscetti, G., Bodo, P., Garofani, P., Abbritti, E.P., Luciani, G., Mazzanti, M., et al. (2011) A Survey on Workers’ Individual Exposure to Crystalline Silica in the Building Industry. La Medicina del lavoro, 102, 370-381.

[3]   Nurminen, M., Corvalan, C., Leigh, J. and Baker, G. (1992) Prediction of Silicosis and Lung Cancer in the Australian Labor Force Exposed to Silica. Scandinavian Journal of Work, Environment & Health, 18, 393-399.
http://dx.doi.org/10.5271/sjweh.1565

[4]   McLaughlin, J.K., Chow, W.H. and Levy, L.S. (1997) Amorphous Silica: A Review of Health Effects from Inhalation Exposure with Particular Reference to Cancer. Journal of Toxicology and Environmental Health, 50, 553-566.
http://dx.doi.org/10.1080/15287399709532054

[5]   Rushton, L. (2012) Evaluation of Cytotoxic, Genotoxic and Inflammatory Responses of Micro- and Nano-Particles of Granite on Human Lung Fibroblast Cell IMR-90. Toxicology Letters, 208, 300-307.
http://dx.doi.org/10.1016/j.toxlet.2011.11.004

[6]   Cocco, P., Rice, C.H., Chen, J.Q., McCawley, M.A., McLaughlin, J.K. and Dosemeci, M. (2001) Lung Cancer Risk, Silica Exposure, and Silicosis in Chinese Mines and Pottery Factories: The Modifying Role of Other Workplace Lung Carcinogens. American Journal of Industrial Medicine, 40, 674-682.
http://dx.doi.org/10.1002/ajim.10022

[7]   Hnizdo, E. and Vallyathan, V. (2003) Chronic Obstructive Pulmonary Disease Due to Occupational Exposure to Silica Dust: A Review of Epidemiological and Pathological Evidence. Occupational and Environmental Medicine, 60, 237-243.
http://dx.doi.org/10.1136/oem.60.4.237

[8]   Zhang, X., Wang, H., Zhu, X., Liu, Y., Wang, L., Dai, Q., et al. (2008) Cohort Mortality Study in Three Ceramic Factories in Jingdezhen in China. Journal of Huazhong University of Science and Technology [Medical Sciences], 28, 386-390.
http://dx.doi.org/10.1007/s11596-008-0404-2

[9]   Bugge, M.D., Foreland, S., Kjærheim, K., Eduard, W., Martinsen, J.I. and Kjuus, H. (2011) Mortality from Non-Malignant Respiratory Diseases among Workers in the Norwegian Silicon Carbide Industry: Associations with Dust Exposure. Occupational and Environmental Medicine, 68, 863-869.
http://dx.doi.org/10.1136/oem.2010.062836

[10]   Bugge, M.D., Kjærheim, K., Foreland, S., Eduard, W. and Kjuus, H. (2012) Lung Cancer Incidence among Norwegian Silicon Carbide Industry Workers: Associations with Particulate Exposure Factors. Occupational and Environmental Medicine, 69, 527-533.
http://dx.doi.org/10.1136/oemed-2011-100623

[11]   Zhang, J.W., Lv, G.C., Yao, J.M. and Hong, X.P. (2010) Assessment of Serum Antioxidant Status in Patients with Silicosis. The Journal of International Medical Research, 38, 884-889.
http://dx.doi.org/10.1177/147323001003800314

[12]   Lin, W., Huang, Y.W., Zhou, X.D. and Ma, Y. (2006) In Vitro Toxicity of Silica Nanoparticles in Human Lung Cancer Cells. Toxicology and Applied Pharmacology, 217, 252-259.
http://dx.doi.org/10.1016/j.taap.2006.10.004

[13]   Ahmad, I., Khan, M.I., Patil, G. and Chauhan, L.K. (2012) Evaluation of Cytotoxic, Genotoxic and Inflammatory Responses of Micro- and Nano-Particles of Granite on Human Lung Fibroblast Cell IMR-90. Toxicology Letters, 208, 300-307.
http://dx.doi.org/10.1016/j.toxlet.2011.11.004

[14]   Su, W.J., Gan, L., Wang, H.J., Zhou, T., Weng, S.F., Liu, F.C. and Chen, W.H. (2009) Experimental Research on Biological Responses of Productive Dusts from Pottery Factories and Tungsten Mines. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi=Zhonghua Laodong Weisheng Zhiyebing Zazhi, 27, 579-583.

[15]   Yang, H., Liu, C., Yang, D., Zhang, H. and Xi, Z. (2009) Comparative Study of Cytotoxicity, Oxidative Stress and Genotoxicity Induced by Four Typical Nanomaterials: The Role of Particle Size, Shape and Composition. Journal of Applied Toxicology, 29, 69-78.
http://dx.doi.org/10.1002/jat.1385

[16]   Bosetti, M., Hench, L. and Cannas, M. (2002) Interaction of Bioactive Glasses with Peritoneal Macrophages and Monocytes in Vitro. Journal of Biomedical Materials Research, 60, 79-85.
http://dx.doi.org/10.1002/jbm.1282

[17]   Tagesson, C., Kallberg, M. and Wingren, G. (1996) Urinary Malondialdehyde and 8-Hydroxydeoxyguanosine as Potential Markers of Oxidative Stress in Industrial Art Glass Workers. International Archives of Occupational and Environmental Health, 69, 5-13.
http://dx.doi.org/10.1007/BF02630732

[18]   Wen, W., Yang, J., Gao, X. and Heng, Z. (2007) Changes of the Certain Genotoxicities in Workers Occupationally Exposed to Arsenic. Journal of Hygiene Research, 36, 340-342.

[19]   Rossi, O., Turini, L., Chellini, E., Buonocore, C. and Loi, A.M. (2004) Survey on Health Status of Workers Exposed in the Past to Carcinogens in a Glass Factory in Leghorn, Italy. La Medicina del lavoro, 95, 465-474.

[20]   Salari-Sharif, P., Asalforoush, M., Ameri, F., Larijani, B. and Abdollahi, M. (2010) The Effect of n-3 Fatty Acids on Bone Biomarkers in Iranian Postmenopausal Osteoporotic Women: A Randomized Clinical Trial. Age, 32, 179-186.
http://dx.doi.org/10.1007/s11357-009-9122-3

[21]   Mohseni-Salehi-Monfared, S.S., Larijani, B. and Abdollahi, M. (2009) Islet Transplantation and Antioxidant Management: A Comprehensive Review. World Journal of Gastroenterology, 15, 1153-1161.
http://dx.doi.org/10.3748/wjg.15.1153

[22]   Hasani-Ranjbar, S., Larijani, B. and Abdollahi, M. (2009) A Systematic Review of the Potential Herbal Sources of Future Drugs Effective in Oxidant-Related Diseases. Inflammation & Allergy Drug Targets, 8, 2-10.
http://dx.doi.org/10.2174/187152809787582561

[23]   Rahimi, R., Nikfar, S., Larijani, B. and Abdollahi, M. (2005) A Review on the Role of Antioxidants in the Management of Diabetes and Its Complications. Biomedicine & Pharmacotherapy, 59, 365-373.
http://dx.doi.org/10.1016/j.biopha.2005.07.002

[24]   Rezaie, A., Parker, R.D. and Abdollahi, M. (2007) Oxidative Stress and Pathogenesis of Inflammatory Bowel Disease: An Epiphenomenon or the Cause? Digestive Diseases and Sciences, 52, 2015-2021.
http://dx.doi.org/10.1007/s10620-006-9622-2

[25]   Rahimi, R., Nikfar, S., Rezaie, A. and Abdollahi, M. (2009) A Meta-Analysis on the Efficacy and Safety of Combined Vitamin C and E Supplementation in Preeclamptic Women. Hypertension in Pregnancy, 28, 417-434.
http://dx.doi.org/10.3109/10641950802629667

[26]   Malekirad, A.A., Mojtabaee, M., Faghih, M., Vaezi, G. and Abdollahi, M. (2012) Effects of the Mixture of Melissa officinalis L., Cinnamomum zeylanicum and Urtica dioica on Hepatic Enzymes Activity in Patients with Nonalcoholic Fatty Liver Disease. International Journal of Pharmacology, 8, 204-208.
http://dx.doi.org/10.3923/ijp.2012.204.208

[27]   Fani, A., Malekirad, A.A., Nazem, H.A., Rahzani, K., Ranjbar, A., Vosogh-Ghanbari, S., et al. (2008) On the Benefit of Cinnamomum zeylanicum for Radiology Unit Staff. Journal of Medical Science, 1-6.

[28]   Zeraatpishe, A., Oryan, S., Bagheri, M.H., Pilevarian, A.A., Malekirad, A.A., Baeeri, M., et al. (2011) Effects of Melissa officinalis L. on Oxidative Status and DNA Damage in Subjects Exposed to Long-Term Low-Dose Ionizing Radiation. Toxicology and Industrial Health, 27, 205-212.
http://dx.doi.org/10.1177/0748233710383889

[29]   Fazli, D., Malekirad, A.A., Pilehvarian, A.A., Salehi, H., Zerratpishe, A., Rahzani, K. and Abdollahi, M. (2012) Effects of Melissa officinalis L. on Oxidative Status and Biochemical Parameters in Occupationally Exposed Workers to Aluminum: A Before after Clinical Trial. International Journal of Pharmacology, 8, 455-458.
http://dx.doi.org/10.3923/ijp.2012.455.458

[30]   Esterabeur, H. and Cheeseman, K. (1990) Determination of Aldehyids Lipid Peroxidation Products: Malondealdhyde and 4-hydroxyl Nonenal. Methods in Enzymology, 186, 407-421.
http://dx.doi.org/10.1016/0076-6879(90)86134-H

[31]   Benzi, I.F. and Strain, S. (1999) Ferric Reducing Antioxidant Assay. Methods in Enzymology, 292, 15-27.

[32]   Moritz, S., Ferahli, S. and Naber, D. (2004) Memory and Attention Performance in Psychiatric Patients: Lack of Correspondence between Clinician-Rated and Patient-Rated Functioning with Neuropsychological Test Results. Journal of the International Neuropsychological Society, 10, 623-633.
http://dx.doi.org/10.1017/S1355617704104153

[33]   Malekirad, A.A., Mirabdollahi, M., Pilehvarian, A.A., Nassajpour, A.A. and Abdollahi, M. (2013) Status of Neurocognitive and Oxidative Stress Conditions in Iron-Steel Workers. Toxicology and Industrial Health. [Epub ahead of print]
http://dx.doi.org/10.1177/0748233713483196

[34]   Malekirad, A.A., Kalantari-Dehaghi, R. and Abdollahi, M. (2013) Clinical, Haematological, and Neurocognitive Findings in Lead-Exposed Workers of a Battery Plant in Iran. Archives of Industrial Hygiene and Toxicology, 64, 497-503.
http://dx.doi.org/10.2478/10004-1254-64-2013-2385

[35]   Malekirad, A.A., Faghih, M., Mirabdollahi, M., Kiani, M., Fathi, A. and Abdollahi, M. (2013) Neurocognitive, Mental Health, and Glucose Disorders in Farmers Exposed to Organophosphorus Pesticides. Archives of Industrial Hygiene and Toxicology, 64, 1-8.
http://dx.doi.org/10.2478/10004-1254-64-2013-2296

[36]   Zhang, X.T., Ni, W.M., Miao, R.M., Liu, X.C., Lu, Y.W., Yang, S.L., et al. (2011) Effects of Oxidative Stress and NF-KappaB Levels in Peripheral Blood Mononuclear Cells on Development of Silicosis. Zhonghua Laodong Weisheng Zhiyebing Zazhi, 29, 251-254.

[37]   Pilger, A., Germadnik, D., Schaffer, A., Theiler, A., Pils, P., Sluka, F., Winker, N. and Rüdiger, H.W. (2000) 8-Hydroxydeoxygua-nosine in Leukocyte DNA and Urine of Quartz-Exposed Workers and Patients with Silicosis. International Archives of Occupational and Environmental Health, 73, 305-310.
http://dx.doi.org/10.1007/s004200000117

[38]   Vuyyuri, S.B., Ishaq, M., Kuppala, D., Grover, P. and Ahuja, Y.R. (2006) Evaluation of Micronucleus Frequencies and DNA Damage in Glass Workers Exposed to Arsenic. Environmental and Molecular Mutagenesis, 47, 562-570.
http://dx.doi.org/10.1002/em.20229

[39]   Lin, T.S., Wu, C.C., Wu, J.D. and Wei, C.H. (2012) Oxidative DNA Damage Estimated by Urinary 8-hydroxy-2’-deoxyguanosine and Arsenic in Glass Production Workers. Toxicology and Industrial Health, 28, 513-521.
http://dx.doi.org/10.1177/0748233711416945

[40]   Zhang, X.T., Ni, W.M., Miao, R.M., Liu, X.C., Lu, Y.W., Yang, S.L., et al. (2011) Effects of Oxidative Stress and NF-kappaB Levels in Peripheral Blood Mononuclear Cells on Development of Silicosis. Chinese Journal of Industrial Hygiene and Occupational Diseases, 29, 251-254.

[41]   Ghiazza, M., Polimeni, M., Fenoglio, I., Gazzano, E., Ghigo, D. and Fubini, B. (2010) Does Vitreous Silica Contradict the Toxicity of the Crystalline Silica Paradigm? Chemical Research in Toxicology, 23, 620-629.
http://dx.doi.org/10.1021/tx900369x

[42]   Kamal, A.A., Gomaa, A., El Khafif, M. and Hammad, A.S. (1989) Plasma Lipid Peroxides among Workers Exposed to Silica or Asbestos Dusts. Environmental Research, 49, 173-180.
http://dx.doi.org/10.1016/S0013-9351(89)80062-3

[43]   Bartoli, D., Battista, G., De Santis, M., Iaia, T.E., Orsi, D., Tarchi, M., Pirastut, R. and Valiani, M. (1998) Cohort Study of Art Glass Workers in Tuscany, Italy: Mortality from Non-Malignant Diseases. Occupational Medicine, 48, 441-445.
http://dx.doi.org/10.1093/occmed/48.7.441

[44]   Pira, E., Manzari, M., Gallus, S., Negri, E., Bosetti, C., Romano, C., et al. (2009) Cancer Mortality in a Cohort of Continuous Glass Filament Workers. Journal of Occupational and Environmental Medicine, 51, 239-242.
http://dx.doi.org/10.1097/JOM.0b013e318193fd0d

[45]   Sankila, R., Kar-jalainen, S., Pukkala, E., Oksanen, H., Hakulinen, T., Teppo, L. and Hakama, M. (1990) Cancer Risk among Glass Factory Workers: An Excess of Lung Cancer? British Journal of Industrial Medicine, 47, 815-818.

[46]   Sripaiboonkij, P., Sripaiboonkij, N., Phanprasit, W. and Jaakkola, M.S. (2009) Respiratory and Skin Health among Glass Microfiber Production Workers: A Cross-Sectional Study. Environmental Health, 8, 36.
http://dx.doi.org/10.1186/1476-069X-8-36

[47]   Gordon, S.B., Curran, A.D., Turley, A., Wong, C.H., Rahman, S.N., Wiley, K. and Morice, A.H. (1997) Glass Bottle Workers Exposed to Low-Dose Irritant Fumes Cough but Do Not Wheeze. American Journal of Respiratory and Critical Care Medicine, 156, 206-210.
http://dx.doi.org/10.1164/ajrccm.156.1.9610042

[48]   Bayrami, M., Hashemi, T., Malekirad, A.A., Ashayeri, H., Faraji, F. and Abdollahi, M. (2012) Electroencephalogram, Cognitive State, Psychological Disorders, Clinical Symptom, and Oxidative Stress in Horticulture Farmers Exposed to Organophosphate Pesticides. Toxicology and Industrial Health, 28, 90-96.
http://dx.doi.org/10.1177/0748233711407243

[49]   Jomova, K., Vondrakova, D., Lawson, M. and Valko, M. (2010) Metals, Oxidative Stress and Neurodegenerative Disorders. Molecular and Cellular Biochemistry, 345, 91-104.
http://dx.doi.org/10.1007/s11010-010-0563-x

[50]   Wang, J., Markesbery, W.R. and Lovell, M.A. (2006) Increased Oxidative Damage in Nuclear and Mitochondrial DNA in Mild Cognitive Impairment. Journal of Neurochemistry, 96, 825-832.
http://dx.doi.org/10.1111/j.1471-4159.2005.03615.x

[51]   Markesbery, W.R. and Lovell, M.A. (2007) Damage to Lipids, Proteins, DNA, and RNA in Mild Cognitive Impairment. JAMA Neurology, 64, 954-956.
http://dx.doi.org/10.1001/archneur.64.7.954

[52]   Praticò, D., Clark, C.M., Liun, F., Rokach, J., Lee, V.Y. and Trojanowski, J.Q. (2002) Increase of Brain Oxidative Stress in Mild Cognitive Impairment: A Possible Predictor of Alzheimer Disease. JAMA Neurology, 59, 972-976.
http://dx.doi.org/10.1001/archneur.59.6.972

[53]   Amin, K.A. and Abd El-Twab, T.M. (2009) Oxidative Markers, Nitric Oxide and Homocysteine Alteration in Hypercholesterolimic Rats: Role of Atorvastatine and Cinnamon. International Journal of Clinical and Experimental Medicine, 2, 254-265.

[54]   Moselhy, S.S. and Junbi, H.H. (2010) Antioxidant Properties of Ethanolic and Aqueous Cinnamon Extracts against Liver Injury in Rats. International Journal of Advances in Pharmaceutical Sciences, 1, 151-155.

[55]   Birdane, Y.O., Büyükokuroglu, M.E., Birdane, F.M., Cemek, M. and Yavuz, H. (2007) Anti-Inflammatory and Antinociceptive Effects of Melissa officinalis L. in Rodents. Revue de Médecine Vétérinaire, 158, 75-81.

[56]   Bolkent, S., Yanardag, R., Karabulut-Bulan, O. and Yesilyaprak, B. (2005) Protective Role of Melissa officinalis L. Extract on Liver of Hyperlipidemic Rats: A Morphological and Biochemical Study. Journal of Ethnopharmacology, 99, 391-398.
http://dx.doi.org/10.1016/j.jep.2005.02.038

 
 
Top