Back
 AJAC  Vol.2 No.2 , May 2011
Investigation of Distribution for Trace Lead and Cadmium in Chinese Herbal Medicines and Their Decoctions by Graphite Furnace Atomic Absorption Spectrometry
Abstract: Lead and cadmium in herbal medicines are highly toxic to living organisms even in low concentrations. An effective method is developed for analysis of trace lead and cadmium in Chinese herbal medicines and their decoctions by graphite furnace atomic absorption spectrometry (GFAAS). The effects of analytical conditions on absorbance were investigated and optimized. A water-dissolving capability for Pb and Cd was investigated, and the contents of different species in five Chinese herbal medicines and their decoctions were analyzed. The content ratios (kow) of n-octanol-soluble Pb or Cd to water-soluble Pb or Cd were evaluated, and the distribution of Pb and Cd in water decoction at stomach and intestine acidities was developed, in the first time. The contents of water-soluble Pb and Cd, n-octanol-soluble Pb and Cd, and their content ratios were related with the kind of medicine and the acidity of the decoction. The proposed method has the advantages of simple operation, high sensitivity and high speed, with 3 σ detection limits of 4.2 pg for Pb and 0.1 pg for Cd.
Cite this paper: nullH. Sun and L. Li, "Investigation of Distribution for Trace Lead and Cadmium in Chinese Herbal Medicines and Their Decoctions by Graphite Furnace Atomic Absorption Spectrometry," American Journal of Analytical Chemistry, Vol. 2 No. 2, 2011, pp. 217-222. doi: 10.4236/ajac.2011.22026.
References

[1]   X. M. Liu, J. P. Wang, Y. Xiong, H. J. Guo, R. D. Liu, R.F. Huang and L. Ma, “Plumbism Following CHINESE Herbal Treatment for Chronic Hepatitis B Virus Infection,” Chinese Journal of Hepatology, Vol. 13, No. 3, 2005, p. 237.

[2]   Z. G. Zhu, S. F. Dong, W. M. Liu and R. N. Hua, “Analysis of the Contents of 11 Metal Elements in Suxiaoweiningchongji,” Journal of the Fourth Military Medical University, Vol. 23, No. 2, 2002, pp. 137-140.

[3]   Marina M. A. Campos, H. Tonuci, S. M. Silva, Bruna de S. Altoé, Dermeval de Carvalho, Eloisa A. M. Kronka, Ana M. S. Pereira, Bianca W. Bertoni, Suzelei de C. Franca and Carlos E. S. Miranda, “Determination of Lead Content in Medicinal Plants by Pre-Concentration Flow Injection Analysis-Flame Atomic Absorption Spectrometry,” Phytochemical Analysis, Vol. 20, No. 6, 2009, pp. 445-449.

[4]   ?. M. M. Flores, A. P. F. Saidelles, J. C. P. Mattos, Edson I. M?ller, J. S. F. Pereira, J. N. G. Paniz and V. L. Dressler, “Determination of Cd and Pb in Medicinal Plants Using Solid Sampling Flame Atomic Absorption Spectrometry,” International Journal of Environmental Analytical Chemistry, Vol. 89, No. 2, 2009, pp. 129-140. doi:10.1080/03067310802578945

[5]   X. D. Yuan, K. H. Ling and C. W. Keung, “The Analysis of Heavy Metals in Chinese Herbal Medicine by Flow Injection-Mercury Hydride System and Graphite Furnace Atomic Absorption Spectrometry,” Phytochemical Analysis, Vol. 20, No. 4, 2009, pp. 293-297. doi:10.1002/pca.1126

[6]   I. C. Chuang, Y. L. Huang and T. H. Lin, “Determination of Lead and Cadmium in Chinese Crude Drugs by Graphite-Furnace Atomic Absorption Spectrometry,” Analytical Sciences, Vol. 15, No. 11, 1999, pp. 1133-1136. doi:10.2116/analsci.15.1133

[7]   X. W. Li, J. Q. Gao and J. L. Zhao, “Determination of Heavy Metal in Chinese Herbs,” Journal of Hygiene Research, Vol. 231, No. 4, 2002, pp. 295-297. doi:10.2116/analsci.15.1133

[8]   C. B. Fuh, H. I. Lin and H.Y. Tsai, “Determination of Lead, Cadmium, Chromium, and Arsenic in 13 Herbs of Tocolysis Formulation Using Atomic Absorption Spectrometry,” Journal of Food and Drug Analysis, Vol. 11, No. 1, 2003, pp. 39-45.

[9]   M. R. Gomez, S. Cerutti, L. L Sombra, M. F Silva and L. D Martínez, “Determination of Heavy Metals for the Quality Control in Argentinian Herbal Medicines by ETAAS and ICP-OES,” Food and Chemical Toxicology, Vol. 45, No. 6, 2007, pp. 1060-1064. doi:10.1016/j.fct.2006.12.013

[10]   S. Arpadjan, G. ?elik, S. Ta?kesen and ?. Gü?er, “Arsenic, Cadmium and Lead in Medicinal Herbs and Their Fractionation,” Food and Chemical Toxicology, Vol. 46, No. 8, 2008, pp. 2871-2875. doi:10.1016/j.fct.2008.05.027

[11]   Y. K. Lü, H. W. Sun, C. G. Yuan and X. P. Yan, “Simultaneous Determination of Trace Cadmium and Arsenic in Biological Samples by Hydride Generation-Double Channel Atomic Fluorescence Spectrometry,” Analytical Chemistry, Vol. 74, No.7, 2002, pp. 1525-1529. doi:10.1021/ac0156971

[12]   Y. L. Yang, G. Y. Yan and Q. Lin, “Determination of Heavy Metal Ions in Chinese Herbal Medicine by Microwave Digestion and RP-HPLC with UV-Vis Detection,” Microchimica Acta, Vol. 144, No. 4, 2004, pp. 297-302. doi:10.1007/s00604-003-0020-6

[13]   G. J. Zhong, “Physiology,” Publishing Company of Sanitation and People, Beijing, 1988.

[14]   S. X. Li, N. S. Deng and Z. Q. Liu, “Speciation Analysis of Zinc in Chinese Traditional Medicine by Flame Atomic Absorption Spectrometry,” Journal of Analytical. Sciences, Vol. 18, No. 2, 2002, pp. 145-148.

[15]   S. X. Li and N. S. Deng, “Speciation Analysis of Manganic in Chinese Herbal Medicines by Flame Atomic Absorption Spectreometry,” Chinese Journal of Analytical Chemistry, Vol. 30, No. 7, 2002, p. 890.

[16]   H. W. Sun, F. X. Qiao, R. Suo, L. X. Li and S. X. Liang, “Simultaneous Determination of Trace Arsenic(III), Antimony(III), Total Arsenic and Antimony in Chinese Medicinal Herbs by Hydride Generation-Double Channel Atomic Fluorescence Spectrometry,” Analytica Chimica Acta, Vol. 505, No. 2, 2004, pp. 255-261. doi:10.1016/j.aca.2003.10.071

[17]   N. S. Deng, “Instruction of Environmental Chemistry,” Publisher of Wuhan University, Wuhan, 2000.

 
 
Top