IJCM  Vol.2 No.2 , May 2011
Thyroid Disorders in Patients with Inflammatory Bowel Diseases
ABSTRACT
Background: The rate of thyroid disorders is reported to be increased in patients with Ulcerative Colitis (UC) and Crohn’s disease (CD) than the normal population. The purpose of this study is to evaluate the prevalance of Thyroid disorders in a group of patients with inflammatory bowel diseases (IBD). Material and Methods: 146 IBD patients (113 UC and 33 CD patients) and 66 healthy control subjects were enrolled into the study. Serum free T4 (FT4), free T3 (FT3), TSH and anti TPO levels of the patients were analyzed retrospectively and and compared with a control group. These cases were also investigated with thyroid ultrasound and nuclear (scintigraphy) imaging. Results: The mean age of IBD patients (76 women) was 42.9 ± 12.4 years. Among the control group 42 were female and their mean age was 40.9 ± 12.1 years. Thyroid gland disease was found in 14 (9.5%, 8 female, 6 male) of 146 IBD patients. The frequency of thyroid disorders has been found to be higher than the control group in patients with control group (14/146 vs. 1/66, p = 0.042). No statistically significant difference has been observed at the thyroid disorder rates between the UC and CD patients (11/113 vs. 3/33, p = 0.912). Hashimoto thyroiditis has been found at 4 (2.7%) of the IBD patients. Conclusion: In accordance with several works published in literature, we have found a higher rate of thyroid disease apperance at IBD patients.

Cite this paper
nullM. Yakut, Y. Üstün, G. Kabacan and I. Soykan, "Thyroid Disorders in Patients with Inflammatory Bowel Diseases," International Journal of Clinical Medicine, Vol. 2 No. 2, 2011, pp. 89-92. doi: 10.4236/ijcm.2011.22018.
References
[1]   [1] J. Powell, H. Shapiro and J. Carbone, “Therappeutic Problems of Ulcerative Colitis with Hyperthyroidisim,” American Journal of Gastroenterology, Vol. 50, No. 2, 1968, pp. 116-124.

[2]   [2] G. Jarnerot, A. K. Azad Khan and S. C. Truelove, “The Thyroid in Ulcerativecolitis and Crohn’s Disease. II. Thyroid Enlargement and Hyperthyroidism in Ulcerative Colitis,” Acta Medica Scandinavica, Vol. 197, 1975, pp. 83-87. doi:10.1111/j.0954-6820.1975.tb04882.x

[3]   [3] M. Cesarini, E. Angelucci and M. Rivera, “Thyroid Disorders and In?ammatory Bowel Diseases: Retro- spective Evaluation of 909 Patients from an Italian Referral Center,” Inflammatory Bowel Diseases, Vol. 16, No. 2, 2010, pp. 186-187.

[4]   [4] A. J. Greenstein, H. D. Janowitz and D. B. Sachar, “The Extra-Intestinal Complications of Crohn’s Disease and Ulcera-Tivecolitis a Study of 700 Patients,” Medicine, Vol. 55, No. 5, 1976, pp. 401-412. doi:10.1097/00005792-197609000-00004

[5]   [5] P. Gimondo, P. Mirk, C. Pizzi, G. Messina and S. Gimondo, “Iafrancesco G. Clinico-Ultrasonographic Assessment of the Thyroid Volume and Function in Chronic Enteritis and Colitis: Preliminary Data,” Radiologia Medica, Vol. 92, No. 3, 1996, pp. 257-260.

[6]   [6] G. Casella, E. De Marco, E. Antonelli, et al., “The Prevalence of Hyper and Hypothyroidism in Patients with Ulcerative Colitis,” Journal of Crohn’s and Colitis, Vol. 2, No. 4, 2008, pp. 327-330. doi:10.1016/j.crohns.2008.09.001

[7]   [7] D. Peretianu, C. Dumitrescu and V. Lotrenau, “Asso- ciation of Hyperthyroidism and Ulcerative Colitis. Report of Two Cases,” Medicine Interne, Vol. 28, No. 1, 1990, pp. 41-45.

[8]   [8] J. K. Trianta?llidis, P. Cherakakis and A. Zervakakis “Coexistence of Hyperthyroidism and Ulcerative Colitis: Report of 4 Cases and a Review of the Literature,” Italian Journal of Gastroenterology, Vol. 24, No. 9, 1992, pp. 494-497.

[9]   [9] C. N. Bernstein, A. Wajda and J. F. Blanchard, “The Clu- stering of Other Chronic In?ammatory Diseases in In- ?ammatory Bowel Disease: A Population-Based Study,” Gastroenterology, Vol. 129, 2005, pp. 827-836. doi:10.1053/j.gastro.2005.06.021

[10]   [10] B. Kantar?eken, A. ?etinkaya, M. ?ahin, “Thyroid Hormon Levels in Ulcerative Colitis Patients,” Akademik Gastroenteroloji Dergisi, Vol. 77, No. 33, 2008, pp. 168- 170.

[11]   [11] B. Tunc, L. Filik, A. Ulker, A. Demirbag and B. Sahin “Subclinical Thyroid Disorders and Inflammatory Bowel Disease,” Romanian Journal of Gastroenterology, Vol. 14, No. 1, 2005, pp. 98-99.

[12]   [12] S. A. Shah, M. A. Peppercorn and J. A. Pallotta, “Au- toimmune (Hashimoto’s) Thyroiditis Associated with Crohn’s Disease,” Journal of Clinical Gastroenterology, Vol. 26, No. 2, 1998, pp. 117-120. doi:10.1097/00004836-199803000-00006

[13]   [13] I. Bank and J. O. Busari, “Crohn’s Disease, Autoimmune Thyroiditis, and Beta-Thalassemia Trait in an Adolescent: An Unusual Combination of Diseases,” European Jour-nal of Pediatrics, Vol. 167, No. 11, 2008, pp. 1343-1346. doi:10.1007/s00431-008-0676-3

[14]   [14] G. Messina, N. Viceconti and B. Trinti, “The Clinical and Echographic Assessment of Thyroid Function and Struc- ture in Patients with a Chronic Inflammatory Intestinal Disease,” Recenti Progressi in Medicina, Vol. 90, No. 1, 1999, pp. 13-16.

[15]   [15] X. Geng, L. Biancone and H. H. Dai, et al. “Tropomyosin Isoforms in ?ntestinal Mucosa: Production of Autoanti- Bodies to Tropomyosin Isoforms in Ulcerative Colitis,” Gastroenterology, 1998, Vol. 114, No. 5, pp. 912-922. doi:10.1016/S0016-5085(98)70310-5

[16]   [16] H. Hasegawa, K. Hasegawa, T. Saito, et al., “A Case of Myopathy with Ulceratif Colitis,” Clinical Neurology, Vol. 30, No. 2, 1990, pp. 184-188.

 
 
Top