NM  Vol.5 No.5 , December 2014
Vitamin D Level in Multiple Sclerosis Patients. Could Vitamin D Level Be Routine Investigation for Multiple Sclerosis Patients?
Abstract: Objectives: To study the prevalence of vitamin D deficiency among newly diagnosed multiple sclerosis patients. Patients and Methods: It is a case control cross matching age related study done on totally 40 subjects (20 patients are newly diagnosed as MS; patients don’t start any medication for MS (naive patients) and 20 subjects are controls with the same age and sex). Base line vitamin D level was measured (i.e. vitamin D, 25-OH (total)) and MRI brain with contrast was done for all patients. Results: Low total vitamin D level was seen among 65% of patients with MS (13/20); however, this was only 20% of normal controls (4/20). Conclusion: Hypovitaminosis D is common in MS patients.
Cite this paper: Ibrahim, M. , Alloush, T. and Rahim, M. (2014) Vitamin D Level in Multiple Sclerosis Patients. Could Vitamin D Level Be Routine Investigation for Multiple Sclerosis Patients?. Neuroscience and Medicine, 5, 201-204. doi: 10.4236/nm.2014.55023.

[1]   Weiner, H.L. (2004) Multiple Sclerosis Is an Inflammatory T-Cell-Mediated Autoimmune Disease. Archives of Neurology, 61, 1613.

[2]   Compston, A. and Coles, A. (2008) Multiple Sclerosis. Lancet, 372, 1502.

[3]   Goodin, D.S. (2014) The Epidemiology of Multiple Sclerosis: Insights to Disease Pathogenesis. Handbook of Clinical Neurology, 122, 231.

[4]   Nylander, A. and Hafler, D.A. (2012) Multiple Sclerosis. Journal of Clinical Investigation, 122, 1180.

[5]   Roach, E.S. (2004) Is Multiple Sclerosis an Autoimmune Disorder? Archives of Neurology, 61, 1615.

[6]   Ascherio, A. and Munger, K.L. (2007) Environmental Risk Factors for Multiple Sclerosis. Part II: Noninfectious Factors. Archives of Neurology, 61, 504.

[7]   Van der Mei, I.A., Ponsonby, A.L., Dwyer, T., et al. (2003) Past Exposure to Sun, Skin Phenotype, and Risk of Multiple Sclerosis: Case-Control Study. BMJ, 327, 316.

[8]   Islam, T., Gauderman, W.J., Cozen, W. and Mack, T.M. (2007) Childhood Sun Exposure Influences Risk of Multiple Sclerosis in Monozygotic Twins. Neurology, 69, 381.

[9]   Orton, S.M., Wald, L., Confavreux, C., et al. (2011) Association of UV Radiation with Multiple Sclerosis Prevalence and Sex Ratio in France. Neurology, 76, 425.

[10]   Ramagopalan, S.V., Handel, A.E., Giovannoni, G., et al. (2011) Relationship of UV Exposure to Prevalence of Multiple Sclerosis in England. Neurology, 76, 1410.

[11]   Salzer, J., Hallmans, G., Nyström, M., et al. (2012) Vitamin D as a Protective Factor in Multiple Sclerosis. Neurology, 79, 2140.

[12]   Munger, K.L., Zhang, S.M., O’Reilly, E., et al. (2004) Vitamin D Intake and Incidence of Multiple Sclerosis. Neurology, 62, 60.

[13]   Mowry, E.M., Waubant, E., McCulloch, C.E., et al. (2012) Vitamin D Status Predicts New Brain Magnetic Resonance Imaging Activity in Multiple Sclerosis. Annals of Neurology, 72, 234.

[14]   Ascherio, A., Munger, K.L., White, R., et al. (2014) Vitamin D as an Early Predictor of Multiple Sclerosis Activity and Progression. JAMA Neurology, 71, 306.

[15]   Smolders, J., et al. (2008) Association of Vitamin D Metabolite Levels with Relapse Rate and Disability in Multiple Sclerosis. Multiple Sclerosis, 14, 1220-1224.

[16]   Correale, J., et al. (2009) Immunomodulatory Effects of Vitamin D in Multiple Sclerosis. Brain, 132, 1146-1160.

[17]   Van der Mei, I.A., et al. (2007) Vitamin D Levels in People with Multiple Sclerosis and Community Controls in Tasmania, Australia. Journal of Neurology, 254, 581-590.

[18]   Runia, T.F., et al. (2012) Lower Serum Vitamin D Levels Are Associated with a Higher Relapse Risk in Multiple Sclerosis. Neurology, 79, 261-266.