IJOHNS  Vol.3 No.6 , November 2014
Typical Aspects of the Granular Cell Tumor of the Oral Cavity
ABSTRACT
Granular cell tumor (GCT) is a rare neoplasm that can occur in any part of the body, but mostly they are located intraorally. Its histogenetic origin remains controversial, but it probably arises from Schwann cells and is generally benign. The tumor is typically asymptomatic and appears as a nodule, with a relatively high predilection for the tongue. This article reports a case of a 72-year-old woman treated at the Center of Oral Diagnosis of the Fundação Hermínio Ometto Dental School. The patient presented with an asymptomatic nodule in the dorsal surface of the tongue for approximately 4 months. The patient was submitted to an excisional biopsy and histopatological examination revealed polyhedral cells with granular aspect. The immunohistochemical staining for S-100 presented strong reactivity, confirming the diagnosis of GCT. Finally, we made a concise discussion about the pathogenesis and fundamental clinico-pathological aspects of GCT making the differential diagnosis.

Cite this paper
Prieto-Oliveira, P. , Vitorino Cardoso, S. , Zumbaio Mistro, F. , Kignel, S. , Cantanhede Orsini Machado de Sousa, S. and Brazão-Silva, M. (2014) Typical Aspects of the Granular Cell Tumor of the Oral Cavity. International Journal of Otolaryngology and Head & Neck Surgery, 3, 318-322. doi: 10.4236/ijohns.2014.36057.
References
[1]   Wang, B.Y., Zagzag, D. and Nonaka, D. (2009) Tumors of Nervous System. In: Barnes, L., Ed., Surgical Pathology of the Head and Neck, 3rd Edition, Informa Healthcare, New York, 669-771.

[2]   Weiss, S.W. and Goldblum, J.R. (2001) Enzinger and Weiss’s Soft Tissue Tumors. 4th Edition, Mosby, St Louis, 1622.

[3]   Speight, P. (2005) Granular Cell Tumor. In: Eveson, J.W., Reichart, P. and Sidransky, D., Eds., World Health Organization Classification of Tumors. Pathology and Genetics of Head and Neck Tumours, IARC Press, Lyon, 185-186.

[4]   Sequeira, O.F., Marcos-Martins, O., Hercules, H.C. and dos Santos, J.L. (1970) Mioblastoma múltiplo com localizacãoo brônquica, lingual e parotidiana. Hospital (Rio J), 77, 1179-1195.

[5]   Rejas, R.A., Campos, M.S., Cortes, A.R., Pinto, D.D. and de Sousa, S.C. (2011) The Neural Histogenetic Origin of the Oral Granular Cell Tumor: An Immunohistochemical Evidence. Medicina Oral, Patologia Oral y Cirugia Bucal, 16, 6-10.
http://dx.doi.org/10.4317/medoral.16.e6

[6]   Fullen, D.R., Reed, J.A., Finnerty, B. and McNutt, N.S. (2001) S100A6 Preferentially Labels Type C Nevus Cells and Nevic Corpuscles: Additional Support for Schwannian Differentiation of Intradermal Nevi. Journal of Cutaneous Pathology, 28, 393-399.
http://dx.doi.org/10.1034/j.1600-0560.2001.028008393.x

[7]   Vered, M., Carpenter, W.M. and Buchner, A. (2009) Granular Cell Tumor of the Oral Cavity: Updated Immunohistochemical Profile. Journal of Oral Pathology Medicine, 38, 150-159.
http://dx.doi.org/10.1111/j.1600-0714.2008.00725.x

[8]   Mittal, K.R. and True, L.D. (1988) Origin of Granules in Granular Cell Tumor. Intracellular Myelin Formation with Autodigestion. Archives of Pathology Laboratory, 112, 302-303.

[9]   Fanburg-Smith, J.C., Meis-Kindblom, J., Fante, R. and Kindblom, L. (1998) Malignant Granular Cell Tumor of Soft Tissue: Diagnostic Criteria and Clinicopathologic Correlation. American Journal of Surgical Pathology, 22, 779-794.
http://dx.doi.org/10.1097/00000478-199807000-00001

[10]   Choi, S.M., Hong, S.G., Kang, S.M., Chae, B.G., Kim, S.J., Park, P.K. and Park, H.S. (2014) A Case of Malignant Granular Cell Tumor in the Sigmoid Colon. Clinical Endoscopy, 47, 197-200.
http://dx.doi.org/10.5946/ce.2014.47.2.197

[11]   Regezi, J.A., Sciubba, J.J. and Jordan, R.C.K. (2011) Oral Pathology: Clinical Pathologic Correlations. 6th Edition, Elsevier Saunders, St Louis, 388.

[12]   Childers, E.L. and Fanburg-Smith, J.C. (2010) Congenital Epulis of the Newborn: 10 New Cases of a Rare Oral Tumor. Annals of Diagnostic Pathology, 15, 157-161.
http://dx.doi.org/10.1016/j.anndiagpath.2010.10.003

[13]   Basile, J.R. and Woo, S.B. (2003) Polypoid S-100-Negative Granular Cell Tumor of the Oral Cavity: A Case Report and Review of Literature. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 96, 70-76.
http://dx.doi.org/10.1016/S1079-2104(03)00097-0

[14]   Eguia, A., Uribarri, A., Gay-Escoda, C., Crovetto, M.A., Martínez-Conde, R. and Aguirre, J.M. (2006) Granular Cell Tumor: Report of 8 Intraoral Cases. Medicina Oral, Patología Oral y Cirugía Bucal, 11, 425-428.

[15]   Becelli, R., Perugini, M., Gasparini, G., Cassoni, A. and Fabiani, F. (2001) Abrikossoff’s Tumor. Journal of Craniofacial Surgery, 12, 78-81.
http://dx.doi.org/10.1097/00001665-200101000-00013

 
 
Top