OJPathology  Vol.4 No.4 , October 2014
Umbilical Endometriosis without Pelvic Surgery
Abstract: We report a recently observed case of primary umbilical endometriosis without previous pelvic surgery. A 41-year-old Japanese woman complained of umbilical nodular tumor. Histopathology revealed endometriosis of an approximate 10 mm resected mass. The stromal cells in endometriosis were immunohistochemically positive for CD10. Two months later the first umbilical surgery, she underwent a left salpingo-oophorectomy and release of adhesion around the left adnexa under a laparoscope. She was treated with dienogest (2 mg/day) for six months after four injections of GnRH analogue for four months. After three years of the follow-up, there were no signs of local relapse and no clinical and ultrasonographic abnormalities due to endometriosis.
Cite this paper: Niwa, K. , Mizuno, Y. , Yano, R. , Ueda, Y. , Narikawa, N. , Tanaka, T. (2014) Umbilical Endometriosis without Pelvic Surgery. Open Journal of Pathology, 4, 171-175. doi: 10.4236/ojpathology.2014.44022.

[1]   Spaziani, E., Picchio, M., Di Filippo, A., De Cristofano, C., Ceci, F. and Stagnitti, F. (2009) Spontaneous Umbilical Endometriosis: A Case Report with One-Year Follow-Up. Clinical Experimental Obstetrics Gynecology, 36, 263-264.

[2]   Rosina, P., Pugliarello, S., Colato, C. and Girolomoni, G. (2008) Endometriosis of Umbilical Cicatrix: Case Report and Review of the Literature. Acta Dermatovenerologica Croatica, 16, 218-221.

[3]   Bagade, P.V. and Guirguis, M.M. (2009) Menstruating from the Umbilicus as a Rare Case of Primary Umbilical Endometriosis: A Case Report. Journal of Medical Case Reports, 3, 9326.

[4]   Victory, R., Diamond, M.P. and Johns, D.A.J. (2007) Villar’s Nodule: A Case Report and Systematic Literature Review of Endometriosis Externa of the Umbilicus. Journal of Minimally Invasive Gynecology, 14, 23-32.

[5]   Kyamidis, K., Lora, V. and Kanitakis, J. (2011) Spontaneous Cutaneous Umbilical Endometriosis: Report of A New Case with Immunohistochemical Study and Literature Review. Dermatology Online Journal, 17, 5.

[6]   Fancellu, A., Pinna, A., Manca, A., Capobianco, G. and Porcu, A. (2013) Primary Umbilical Endometriosis. Case Report and Discussion on Management Options. International Journal of Surgery Case Reports, 4, 1145-1148.

[7]   Goldberg, J.M. and Bedaiwy, M.A. (2007) Recurrent Umbilical Endometriosis after Laparoscopic Treatment of Minimal Pelvic Endometriosis: a case report. The Journal of Reproductive Medicine, 52, 551-552.

[8]   Michowitz, M., Baratz, M. and Stavorovsky, M. (1983) Endometriosis of the Umbilicus. Dermatologica, 167, 326-330.

[9]   Chatzikokkinou, P., Thorfinn, J., Angelidis, I.K., Papa, G. and Trevisan, G. (2009) Spontaneous Endometriosis in an Umbilical Skin Lesion Acta dermatovenerologica Alpina, Panonica, et Adriatica, 18, 126-130.

[10]   Dessy, L.A., Buccheri, E.M., Chiummariello, S., Gagliardi, D.N. and Onesti, M.G. (2008) Umbilical Endometriosis, Our Experience. In Vivo, 22, 811-815.

[11]   Latcher, J.W. (1953) Endometriosis of the Umbilicus. American Journal of Obstetrics Gynecology, 66, 161-168.

[12]   Khaled, A., Hammami, H., Fazaa, B., Zermani, R., Ben Jilani, S. and Kamoun, M.R. (2008) Primary Umbilical Endometriosis: A Rare Variant of Extragenital Endometriosis. Pathologica, 100, 473-475.

[13]   Obata, K., Ikoma, N., Oomura, G. and Inoue, Y. (2013) Clear Cell Adenocarcinoma Arising from Umbilical Endometriosis. Journal of Obstetrics and Gynaecology Research, 39, 455-461.

[14]   Dadhwal, V., Gupta, B., Dasgupta, C., Shende, U. and Deka, D. (2011) Primary Umbilical Endometriosis: A Rare Entity. Archives of Gynecology and Obstetrics, 283, 119-120.

[15]   Lauslahti, K. (1972) Malignant External Endometriosis: A Case of Adenocarcinoma of Umbilical Endometriosis. Acta Pathologica et Microbiologica Scandinavica, Section A, Pathology, 233, 98-102.

[16]   Barbaros, U., Iyibozkurt, A.C., Gulluoglu, M., Barbaros, M., Erbil, Y., Tunali, V. and Mercan, S. (2005) Endometriotic Umbilical Port Site Metastasis after Laparoscopy. American Journal of Obstetrics Gynecology, 193, 1761-1763.