Health  Vol.3 No.5 , May 2011
Impact of chemical elements on heart failure progression in coronary heart disease patients
ABSTRACT
Background. The high prevalence, poor prog-nosis of patients with coronary heart disease with chronic heart failure determine the relevance of the study pathophysiological and molecular mechanisms of this pathology. Researches of the trace element metabolism in the myocardium are scarce. With this in mind, an attempt was made to analyze the relationship of macro and trace elements metabolism with the functional state of the myocardium in coronary heart disease patients against the background of chronic heart failure progression. Methods and Results. To study the content of the chemical elements (S, K, Ca, Cr, Fe, Ni, Cu, Zn, Se, Rb, Sr) in the myocardium of 43 patients with coronary heart disease, use was made of X-ray fluorescence with synchrotron radiation. While doing autopsy, 43 samples of left ventricle myocardium were taken off the cardiac callosity. Myocardium samples were subjected to histological examination. Dynamics of macro and trace elements content in the myocardium reflects the development of energy deficiency and disorders of myocardial microcirculation with a decrease of systolic myocardial function. Structural/functional disorders in the myocardium of the left ventricle of patients with coronary heart disease that accompany the progression of chronic heart failure are associated with profound changes of metabolic processes in heart muscle. Conclusions. The structural/ functional changes accompanying chronic heart failure progression are associated with wide variations of metabolic processes in the myocardium, which could be evaluated by the content of chemical elements in tissue.

Cite this paper
nullAlexander, K. , Oksana, K. , Elena, L. , Irina, L. , Galina, O. , Aleksander, C. , Evgeni, K. and Alexander, V. (2011) Impact of chemical elements on heart failure progression in coronary heart disease patients. Health, 3, 263-270. doi: 10.4236/health.2011.35047.
References
[1]   Focused update (2009) ACCF/AHA guidelines for the diagnosis and management of heart failure in adults: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: Developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation, 119, 1977-2016.

[2]   Ratmanova, A. (2009) Cardiovascular morbidity and lethality statistics in European countries (2008). Medicine Review, 1, 6-12.

[3]   Sato, Y., Kita, T., Takatsu, Y. and Kimura, T. (2004) Biochemical markers of myocyte injury in heart failure. Heart, 90, 1110-1113. doi:10.1136/hrt.2003.023895

[4]   St. John Sutton, M.G. and Sharpe, N. (2000) Left ventricular remodeling after myocardial infarction. Circulation, 101, 2981-2988.

[5]   Kassiri, Z., Zhong, J., Guo, D., et al. (2009) Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction. Circulation: Heart Failure, 2, 446-455. doi:10.1161/CIRCHEARTFAILURE.108.840124

[6]   Rashed, M.N., Ahmed, M.M., Al-Hossainy, A.F. and Abd, S.M. (2010) Trends in speciation analysis of some heavy metals in serum of patients with chronic hepatitis C and chronic hepatitis B using differential pulse adsorptive stripping voltammetric measurement and atomic absorption spectrophotometry. Journal of Trace Elements in Medicine and Biology, 24, 138-145. doi:10.1016/j.jtemb.2009.11.006

[7]   Siddiqui, M.K.J., Jyoti, Singh, S., Mehrotra, P.K., Singh, K. and Sarangi, R. (2006) Comparison of some trace elements concentration in blood, tumor free breast and tumor tissues of women with benign and malignant breast lesions: An Indian study. Environment International, 32, 630-637. doi:10.1016/j.envint.2006.02.002

[8]   Miner, E.C. and Miller, W.L. (2006) A looc between the cardiomyocytes:the extracellular matrix in heart failure. Mayo Clinic Proceedings, 81, 71-76. doi:10.4065/81.1.71

[9]   ASSC/SECI (2010) National recommendations on diagnostics and treatment of CHF (3rd revision). Heart Failure, 55, 3-62.

[10]   Zile, M.R. and Brutsaert, D.L. (2002) New concepts in diastolic dysfunction and diastolic heart failure: Part I diagnosis, prognosis, and measurements of diastolic function. Circulation, 105, 1387-1393. doi:10.1161/hc1102.105289

[11]   Ramani, G.V., Uber, P.A. and Mehra, M.R. (2010) Chronic heart failure: contemporary diagnosis and management. Mayo Clinic Proceedings, 85, 180-195. doi:10.4065/mcp.2009.0494

[12]   Beltrami, C.A., Finato, N., Rocco, M., Feruglio, G.A., et al. (1994) Structural basis of endstage failure in ischemic cardiomyoparthy in humans. Circulation, 89, 151-163.

[13]   Novelli, E.L.B., Diniz, Y.S., Machado, T., Proen, B., et al. (2000) Toxic mechanism of nickel exposure on cardiac tissue. Toxic Substance Mechanisms, 19, 177-187. doi:10.1080/107691800300119374

[14]   Okuneva, G.N., Levicheva, E.N., Loginova, I.Yu., et al. (2009) Myocardium dynamics in health and transposition of the great arteries. Pediatry G.N. Speransky Journal, 87, 29-33.

[15]   Patterson, K.Y. and Veillon, C. (2001) Stable isotopes of minerals as metabolic tracers in human nutrition research. Experimental Biology and Medicine, 226, 271-282.

[16]   American Diabetes Association (2004) Nutrition principles and recommendations in diabetes (position statement). Diabetes Care, 27, S36-S46. doi:10.2337/diacare.27.2007.S36

[17]   Cefalu, W.T. and Hu, F.B. (2004) Role of chromium in human health and in diabetes. Diabetes Care, 27, 2741-2751. doi:10.2337/diacare.27.11.2741

[18]   Chowdhury, S., Pandit, K. and Roychowdury, P. (2003) Role of chromium in human metabolism, with special reference to type 2 diabetes. Journal of the Association of Physicians of India, 51, 701-705.

[19]   Diastolic Heart Failure (2004) Challenges of diagnosis and treatment. American Family Physician, 69, 2609-2617.

[20]   Arredondo, M. and Nunez, M.T. (2005) Iron and copper metabolism. Molecular Aspects of Medicine, 26, 313- 327. doi:10.1016/j.mam.2005.07.010

[21]   Bie de, P., Sluis van de, B., Klomp, L. and Wijmenga, C. (2005) The many faces of the copper metabolism protein MURR1/COMMD1. Journal of Heredity (Special Issue), 96, 803-811.

[22]   Palmer, B.M., Vogt, S., Chen, Z., Lachapelle, R.R. and Lewinter, M.M. (2006) Intracellular distributions of essential elements in cardiomyocytes. Journal of Structural Biology, 155, 12-21. doi:10.1016/j.jsb.2005.11.017

[23]   Tubek, S. (2007) Selected zinc metabolism parameters and left ventricle mass in echocardiographic examination in primary arterial hypertension. Biological Trace Element Research, 118, 138-145. doi:10.1007/s12011-007-0021-0

[24]   Campbell, J.D. (2004) Alzheimer’s disease: Minerals and Essential fatty acids. Journal of Orthomolecular Medicine, 19, 173-182.

[25]   Zaugg, C.E. and Buser, P.T. (2001) When calcium turns arrhythmogenic: Intracellular calcium handling during the development of hypertrophy and heart failure. Croatian Medical Journal, 42, 24-32.

[26]   Zachara, B.A., Gromadzińska, J., Wasowicz, W. and Zbróg, Z. (2006) Red blood cell and plasma glutathione peroxidase activities and selenium concentration in patients with chronic kidney disease: A review. Acta Biochimica Polonica, 53, 663-677.

[27]   Lu, J., Berndt, C. and Holmgren, A. (2009) Metabolism of selenium compounds catalyzed by the mammalian selenoprotein thioredoxin reductase. Biochimica et Biophysica Acta (BBA), 1790, 1513-1519.

[28]   Lescure, A., Deniziak, M., Rederstorff, M. and Krol, A. (2008) Molecular basis for the role of selenium in muscle development and function. Chemistry & Biodiversity, 5, 408-413. doi:10.1002/cbdv.200890041

[29]   Orndahl, G., Rindby, A. and Selin, E. (1982) Myotonic dystrophy and selenium. Acta Medica Scandinavica, 211, 493-499. doi:10.1111/j.0954-6820.1982.tb01988.x

 
 
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