Objective: To compare the
efficacy of Oxytocin versus Methylergometrine in active management of third
stage of labour in reducing risk of postpartum hemorrhage. Methods: This study
was carried out by randomly assigning into two groups with 150 women in each
group. Group 1 included patients
who received injection Oxytocin 10 IU intramuscular within one minute of the birth
of the baby. Injection Methylergometrine (0.2 mg) was given intravenously at
the delivery of anterior shoulder of the baby to women in Group 2. Outcome
measures were the duration of third stage, blood loss, pre and post-delivery
hematocrit, side effects and incidence of PPH. Statistical analysis was done
using Chi square test, Fischers test, Mann Whitney test, and t test. p <
0.05 was considered significant. Results: Mean duration of third stage of
labour, mean blood loss, post-delivery fall in hematocrit and need for
additional uterotonics were significantly less in the Group 2. However side
effects like nausea, vomiting and rise in blood pressure were significantly
higher in women in Group 2 (p = 0.000). Conclusion: Methylergometrine is more
effective than Oxytocin in reducing the duration of third stage of labour and
blood loss but has significant side effects like nausea, vomiting and rise in
Cite this paper
Boopathi, A. , Nayak, S. , Rao, A. and Rao, B. (2014) Oxytocin versus Methylergometrine in the Active Management of Third Stage of Labour. Open Journal of Obstetrics and Gynecology
, 666-671. doi: 10.4236/ojog.2014.411093
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