JBM  Vol.2 No.6 , August 2014
Peste des Petits Ruminants Vaccine (Nigerian Strain 75/1) Confers Protection for at Least 3 Years in Sheep and Goats
ABSTRACT


The present study reports the duration of immunity and protective efficacy of Peste des Petits Ruminants (PPR) vaccine (Nigerian strain 75/1) in sheep and goats. A total of 105 sheep and goats were divided into three groups A, B and C. Group A received normal recommended dose (1.0 ml) of PPR vaccine, group B received half dose (0.5 ml) of PPR vaccine and group C was kept as unvaccinated control group in contact with vaccinated animals. The post vaccination dynamics of antibodies against PPR virus was studied. It was found that significant antibody titres persisted for 3 years post vaccination in sheep and goats vaccinated with either full dose or half dose of PPR vaccine. The challenge protection studies were carried out in experimental animals at 24 and 36 month post vaccination. The vaccinates withstood challenge and were found completely resistant clinically and virologically to virulent PPR virus for 24 and 36 months post vaccination. The unvaccinated control animals developed typical clinical signs of PPR and the challenged virus was detected in ocular, nasal and oral secretions of these animals. This study demonstrated that a single immunization with PPR vaccine conferred solid protection in sheep and goats for 3 years.



Cite this paper
Zahur, A. , Irshad, H. , Ullah, A. , Afzal, M. , Latif, A. , Ullah, R. , Farooq, U. , Samo, M. and Jahangir, M. (2014) Peste des Petits Ruminants Vaccine (Nigerian Strain 75/1) Confers Protection for at Least 3 Years in Sheep and Goats. Journal of Biosciences and Medicines, 2, 27-33. doi: 10.4236/jbm.2014.26005.
References
[1]   Gibbs, E., Taylor, W., Lawman, M. and Bryant, J. (1979) Classification of Peste des Petits Ruminants Virus as the Fourth Member of the Genus Morbillivirus. Intervirology, 11, 268-274. http://dx.doi.org/10.1159/000149044

[2]   Baldock, C., Forman, T., Geering, B. and Taylor, B. (1999) New Technologies in the Fight Against Transboundary Animal Diseases. Rome.

[3]   Amjad, H., Forsyth, M., Barrett, T. and Rossiter, P. (1996) Peste des Petits Ruminants in Goats in Pakistan. Veterinary Record, 139, 118-119. http://dx.doi.org/10.1136/vr.139.5.118

[4]   Zahur, A., Irshad, H., Hussain, M., Ullah, A., Jahangir, M., Khan, M.Q. and Farooq, M.S. (2008) The Epidemiology of Peste des Petits Ruminants in Pakistan. Rev Sci Tech (International Office of Epizootics), 27, 877-884.

[5]   Zahur, A., Ullah, A., Hussain, M., Irshad, H., Hameed, A., Jahangir, M. and Farooq, M. (2011) Sero-Epidemiology of Peste des Petits Ruminants (PPR) in Pakistan. Preventive Veterinary Medicine, 102, 87-92. http://dx.doi.org/10.1016/j.prevetmed.2011.06.011

[6]   Anderson, J. and McKay, J.A. (1994) The Detection of Anti-bodies Against Peste des Petits Ruminants Virus in Cattle, Sheep and Goats and the Possible Implications to Rinderpest Control Programmes. Epidemiology & Infection, 112, 225-231. http://dx.doi.org/10.1017/S0950268800057599

[7]   Libeau, G., Prehaud, C., Lancelot, R., Colas, F., Guerre, L., Bishop, D. and Diallo, A. (1995) Development of a Competitive ELISA for Detecting Antibodies to the Peste des Petits Ruminants Virus Using a Recombinant Nucleoprotein. Research in Veterinary Science, 58, 50-55. http://dx.doi.org/10.1016/0034-5288(95)90088-8

[8]   Forsyth, M. and Barrett, T. (1995) Evaluation of Polymerase Chain Reaction for the Detection and Characterization of Rinderpest and Peste de Petit Ruminant’s Viruses for Epide-miological Studies. Virus Research, 39, 151-163. http://dx.doi.org/10.1016/0168-1702(95)00076-3

[9]   Diallo, A., Minet, C., Le Goff C., Berhe, G., Albina, E., Libeau, G. and Barrett T. (2007) The Threat of Peste des Petits Ruminants: Progress in Vaccine Development for Disease Control. Vaccine, 25, 5591-5597. http://dx.doi.org/10.1016/j.vaccine.2007.02.013

[10]   Adu, F. and Nawathe D. (1981) Safety of Tissue Culture Rin-derpest Vaccine in Pregnant goats. Tropical Animal Health and Production, 13, 166-166. http://dx.doi.org/10.1007/BF02237916

[11]   Taylor, W. (1984) The Distribution and Epidemiology of Peste des Petits Ruminants. Preventive Veterinary Medicine, 2, 157-166. http://dx.doi.org/10.1016/0167-5877(84)90059-X

[12]   Diallo, A., Taylor, W.P., Lefevre, P.C. and Provost, A. (1989) Attenuation D'une Ouche De Virus De La Peste des Petits Ru-minants: Candidat Pour un Vaccin Homologue Vivant. Rev Elev Med Vet Pay, 42, 311-319.

[13]   Awa, DN., Ngagnou, A., Tefiang, E., Yaya, D, and Njoya, A. (2002) Post Vaccination and Colostral Peste des Petits Ruminants Antibody Dynamics in Research Flocks of Kirdi Goats and Foulbe Sheep of North Cameroon. Preventive Veterinary Medicine, 55, 265-271. http://dx.doi.org/10.1016/S0167-5877(02)00013-2

[14]   Intizar, M., Ahmad, M., Anjum, A, and Hanif, A. (2009) Comparative Efficacy of Peste des Petits Ruminants (PPR) Vaccines Available in Pakistan in Sheep and Goats. Pakistan Veterinary Journal, 29.

[15]   Siddique, M., Rahman, M., Chowdhury, S., Kafi, M. and Alam, M. (2006) Determination of Efficacy of Thermostable PPR Live Homologous Vaccine Incubated at Room Temperature for 14 Days. BangladeshJVetMed, 4, 43-46.

[16]   Plowright, W. (1984) The Duration of Immunity in Cattle following Inoculation of Rinderpest Cell Culture Vaccine. Journal of Hygiene-Cambridge, 92, 285-296. http://dx.doi.org/10.1017/S0022172400064524

[17]   Martrenchar, A., Bouchel, D., Zoyem, N., Thiaucourt, F. and Lambert, M. (1997) Risk Factors Responsible for the Appearance of Individual Clinical Signs in Small Ruminants in Northern Cameroon. Small Ruminant Research, 26, 45-52. http://dx.doi.org/10.1016/S0921-4488(96)00975-3

[18]   Singh, R., Saravanan, P., Sreenivasa, B., Singh, R. and Ban-dyopadhyay, S. (2004) Prevalence and Distribution of Peste des Petits Ruminants Virus Infection in Small Ruminants in India. Rev Sci Tech (International Office of Epizootics), 23, 807-819.

[19]   Lefevre, P.C, and Diallo, A. (1990) Peste des Petits Ruminants. Rev Sci Tech (International Office of Epizootics), 9, 935-981.

[20]   Roeder, P.L. and Obi, T.U. (1999) Recognizing Peste des Petits Ruminants: A Field Manual. In: Food and Agriculture Organization of the United Nations. Rome. ftp://ftp.fao.org/docrep/FAO/003/X1703E/X1703E00.PDF.

[21]   Abubakar, M., Ali, Q. and Khan, H.A. (2008)Prevalence and Mortality Rate of Peste des Petitis Ruminant (PPR): Possible Association with Abortion in Goat. Tropical Animal Health and Production, 40, 317-321. http://dx.doi.org/10.1007/s11250-007-9105-2

[22]   Losos, G.J. (1986) Infectious Tropical Diseases of Domestic Ani-mals. Longman Scientific & Technical.

[23]   Cosby, S.L., Kai, C. and Yamanouchi, K. (2005) Immunology of Rin-derpest—An Immunosuppression but a Lifelong Vaccine Protection. In: Barrett, T., Paul-Pierre, P. and Taylor, W., Eds. Rinderpest and Peste des Petits Ruminants: Virus Plagues of Large and Small Ruminants. Pirbright, United Kingdom, 196.

 
 
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