CRCM  Vol.3 No.8 , August 2014
Infective Endocarditis with Negative Cultures: A Defiant Diagnosis
ABSTRACT

The diagnosis and management of blood culture-negative endocarditis constitute a real clinical challenge and a systemic approach is necessary for a successful outcome. The authors report a case of a female patient aged 26, with previous clinical history of valve disease and heart failure NYHA class II, with decompensation of co-morbidities associated with fever, productive cough, nonselective anorexia and unquantified weight loss with one month of evolution with negative blood cultures. Transesophageal echocardiography revealed the presence of severe pulmonary hypertension and mitral valve vegetations in the context of positive serology for Q fever. Herein, the authors report a case of blood culture-negative endocarditis and present a brief review on the management of this medical condition. We highlighted the diagnostic difficulties of blood culture-negative endocarditis and subacute clinical presentation, which sometimes present with fever of unknown origin and complaints of deterioration of cardiac function, thus creating a challenging differential diagnosis.


Cite this paper
Rocha, C. , Clérigo, V. , Fernandes, L. , Rodrigues, A. , Sargento, D. and Silva, G. (2014) Infective Endocarditis with Negative Cultures: A Defiant Diagnosis. Case Reports in Clinical Medicine, 3, 460-464. doi: 10.4236/crcm.2014.38101.
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