Objectives: This study aimed to evaluate the fatigue in patients with undifferentiated spondyloarthritis [USpA], and its relationship with disease-specific variables, spinal mobility measures and healthy related quality of life [HRQOL]. Methods: Eighty patients with USpA and forty healthy subjects were included in this study. The multidimensional assessment of fatigue [MAF] and the generic instrument Short Form 36 [SF 36] were used in patient and control groups to assess fatigue and [HRQOL]. Fatigue was also assessed with the Bath ankylosing spondylitis disease activity index [BASDAI] fatigue item. The evaluation included the activity of the disease [BASDAI], functional status [Bath ankylosing spondylitis functional index], and visual analog scale [VAS] of axial and joint pain. Demographics and disease-related data were obtained. Results: Patients with USpA had higher scores in MAF total and in all MAF subgroup scales than controls. All SF-36 subgroups scores were also found to be significantly lower in patients. Severe fatigue experienced 60% in patients. MAF total scores were found to be significantly correlated with morning stiffness, BASDAI, Bath ankylosing spondylitis functional index (BASFI), BASDAI fatigue, VAS-axial, and SF-36 subgroups scores in patients [p < 0.05]. Conclusions: The patients with USpA defined significantly more fatigue and lower HRQOL when compared with healthy persons. MAF was found to be related with the clinical and functional status and health-related quality of life of patients with USpA.
 Dougados, M., Linden, S., Juhlin, R., et al. (1991) The European Spondyloarthropathy Study Group Preliminary Criteria for the Classification Spondyloarthropathy. Arthritis & Rheumatism, 34, 1218-1227.
 Lin, Z., Gu, J., He, P., et al. (2011) Multicenter Validation of the Value of BASFI and BASDAI in Chinese Ankylosing Spondylitis and Undifferentiated Spondyloarthropathy Patients. Rheumatology International, 3, 233-238.
 Spoorenberg, A., Heijde, D., Klerk, E., et al. (1999) A Comparative Study of the Usefulness of the Bath Ankylosing spondylitis Functional Index and the Dougados Functional Index in the Assessment of Ankylosing Spondylitis. The Journal of Rheumatology, 26, 961-965.
 Claudepierre, P., Sibila, J., Goupille, P., et al. (1997) Evaluation of a French Version of the Bath Ankylosing spondylitis Disease Activity Index in Patients with Spondylarthropathy. Journal of Rheumatology, 24, 1954-1958.
 Keikkila, S., Vitanen, J.V., Kautiainen, H., et al. (2002) Functional Long Term Changes in Patients with Spondyloarthropathy. Clinical Rheumatology, 21, 119-122.
 Van Tubergen, A., Coenen, J., Landewé, R., et al. (2002) Assessment of Fatigue in Patients with Ankylosing Spondylitis: Apsychometric Analysis. Arthritis Care & Research, 47, 8-16.
 Neuberger, G.B. (2003) Measures of Fatigue. Arthritis Care & Research, 49, 175-183.
 Akkoc, Y., Karatepe, A.G., Akar, S., et al. (2005) A Turkish Version of the Bath Ankylosing Spondylitis Disease Activity index: Reliability and Validity. Rheumatology International, 25, 280-284.
 Garrett, S.L., Jenkinson, T.R., Kennedy, L.G., et al. (1994) A New Approach to Defining Disease Status in Ankylosing spondylitis: The Bath Ankylosing Spondylitis Disease Activity Index. The Journal of Rheumatology, 21, 2286-2291.
 Calin, A., Garrett, S.L., Whitelock, H.C., et al. (1994) A New Approach to Defining Functional Ability in Ankylosing Spondylitis: The Development of the Bath Ankylosing Spondylitis Functional Index (BASFI). The Journal of Rheumatology, 21, 2281-2285.
 Yanik, B., Gursel, Y.K., Kutlay, S., et al. (2005) Adaptation of the Bath Ankylosing Spondylitis Functional Index to the Turkish Population, Its Reliability and Validity: Functional Assessment in AS. Clinical Rheumatology, 24, 41-47.
 Ware Jr., J.E. (2000) SF-36 Health Survey Update. Spine, 25, 3130-3139.
 Aissaoui, N., Rostom, S., Hakkou, J., et al. (2012) Fatigue in Patients with Ankylosing Spondylitis: Prevalence and Relationships with Disease-Specific Variables, Psychological Status, and sleep Disturbance. Rheumatology International, 32, 2117-2124.
 Da Costa, D., Dritsa, M., Ring, A., et al. (2004) Mental Health Status and Leisure-Time Physical Activity Contribute to Fatigue Intensity in Patients With Spondylarthropathy. Arthritis & Rheumatism (Arthritis Care & Research), 51, 1004-1008.
 Jones, S.D., Koh, W.H., Steiner, A., et al. (1996) Fatigue in Ankylosing Spondylitis: Its Prevalence and Relationship to Disease Activity, Sleep, and Other Factors. The Journal of Rheumatology, 23, 487-490.
 Roussou, E. and Sultana, S. (2010) The Bath Ankylosing Spondylitis Activity and Function Indices (BASDAI and BASFI) and Their Correlation with Main Symptoms Experienced by Patients with Spondyloarthritis. Clinical Rheumatology, 29, 869-874.
 Turan, Y., Duruoz, M.T., Bal, S., et al. (2007) Assessment of Fatigue in Patients with Ankylosing Spondylitis. Rheumatology International, 27, 847-852.
 Dernis-Labous, E., Messow, M. and Dougados, M. (2003) Assessment of Fatigue in the Management of Patients with Ankylosing Spondylitis. Rheumatology (Oxford), 42, 1523-1528.
 Dagfinrud, H., Vollestad, N.K., Loge, J.H., et al. (2005) Fatigue in Patients with Ankylosing Spondylitis: A Comparison with the General Population and Associations with Clinical and seLf-Reported Measures. Arthritis Care & Research, 53, 5-11.
 Yacoub, Y., Amine, B., Laatiris, A., et al. (2010) Assessment of Fatigue in Moroccan Patients with Ankylosing Spondylitis. Clinical Rheumatology, 29, 1295-1299.
 Burgos-Vargas, R. and Casasola-Vargas, J.C. (2010) From Retrospective Analysis of Patients with Undifferentiated Spondyloarthritis (SpA) to Analysis of Prospective Cohorts and Detection of Axial and Peripheral SpA. The Journal of Rheumatology, 37, 1091-1095.