Purpose: To identify and
interrogate the role of Gallium-67 scintigraphy in the diagnosis of
Sarcoidosis. Methods: A retrospective study of 75 patients with suspected
Sarcoidosis in a large teaching hospital with a specialist Sarcoidosis Centre.
Results: Ga-67 scintigraphy in patients considered on clinical grounds to have
Sarcoidosis is a useful and sensitive test, and furthermore, by relaxing the interpretation
of gallium scintigraphy sensitivity may be increased (from 20% to 80%) for a
relatively small drop in specificity. Conclusions: The sensitivity of
diagnostic power may be increased with a change in diagnostic criteria at the
expense of only a small drop in specificity. In the context of
Neurosarcoidosis, our results support the theory that Ga-67 scintigraphy has
value in identifying potential, asymptomatic biopsy sites outside of the CNS
that may not be identified by other forms of imaging.
Cite this paper
Allard, A. , Buscombe, J. and Kidd, D. (2014) The Role of Gallium (Ga-67) Scintigraphy in the Diagnosis of Sarcoidosis. Modern Research in Inflammation
, 99-107. doi: 10.4236/mri.2014.33012
 Mayock, R.L., Bertrand, P., Morrison, C.E. and Scott, J.H. (1963) Manifestations of Sarcoidosis—Analysis of 145 Patients, with a Review of Nine Series Selected from the Literature. The American Journal of Medicine, 35, 67-89.
 Joint Statement on Sarcoidosis (JSS) (1999) Statement on Sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) Adopted by the ATS Board of Directors and by the ERS Executive Committee. American Journal of Respiratory and Critical Care Medicine, 160, 736-755.
 Kidd, D. and Beynon, H.L.C. (2003) Neurological Complications of Systemic Sarcoidosis. Sarcoidosis, Vasculitis and Diffuse Lung Diseases, 20, 85-94.
 Rybicki, B.A., Major, M., Popovich Jr., J., Maliarik, M.J. and Iannuzzi, M.C. (1997) Racial Differences in Sarcoidosis Incidence: A 5-Year Study in a Health Maintenance Organization. American Journal of Epidemiology, 145, 234-241.
 Milman, N. and Selroos, O. (1990) Pulmonary Sarcoidosis in the Nordic Countries 1950-1981: Epidemiology and Clinical Picture. Sarcoidosis, 7, 50-57.
 Pietinalho, A., Hiraga, Y., Hosoda, Y., Lofroos, A.B., Yamaguchi, M. and Selroos, O. (1995) The Frequency of Sarcoidosis in Finland and Hokkaido, Japan: A Comparative Epidemiological Study. Sarcoidosis, 12, 61-67.
 Woodard, B.H., Rosenberg, S.I., Farnham, R. and Adams, D.O. (1982) Incidence and Nature of Primary Granulomatous Inflammation in Surgically Removed Material. The American Journal of Surgical Pathology, 6, 119-129.
 Sulavik, S.B., Spencer, R.P., Weed, D.A., Shapiro, H.R., Shiue, S.T. and Castriotta, R.J. (1990) Recognition of Distinctive Patterns of Gallium-67 Distribution in Sarcoidosis. Journal of Nuclear Medicine, 31, 1909-1914.
 Schuster, D.M. and Alazraki, N. (2002) Gallium and Other Agents in Diseases of the Lung. Seminars in Nuclear Medicine, 32, 193-211. http://dx.doi.org/10.1053/snuc.2002.124178
 Ota, K., Tsunemi, T., Saito, K., Yamanami, F., Watanabe, M., Irioka, T. and Mizusawa, H. (2009) 18F-FDG PET Successfully Detects Spinal Cord Sarcoidosis. Journal of Neurology, 256, 1943-1946.
 Treglia, G., Taralli, S. and Giordano, A. (2011) Emerging Role of Whole Body 18F-Fluorodeoxyglucose Positron Emission Tomography as a Marker of Disease Activity in Patients with Sarcoidosis: A Systematic Review. Sarcoidosis, Vasculitis and Diffuse Lung Diseases, 28, 87-94.
 Keijsers, R.G., Grutters, J.C., Thomeer, M., Du Bois, R.M., Van Buul, M.M., Lavalaye, J., Van den Bosch, J.M. and Verzijlbergen, F.J. (2011) Imaging the Inflammatory Activity of Sarcoidosis: Sensitivity and Interobserver Agreement of (67)Ga Imaging and (18)FDG PET. The Quarterly Journal of Nuclear Medicine and Molecular Imaging, 55, 66-71.