OJOG  Vol.4 No.10 , July 2014
Metastatic Carcinoma of the Uterine Cervix from Rectal Carcinoma: A Case Report and Review of the Literature
ABSTRACT

Primary adenocarcinomas of the uterine cervix account for 5% - 15% of all cervical malignancies, but secondary adenocarcinomas from extragenital cancers are rare. Only 35 cases have been reported in the literature since 1941. We report a 52-year-old Japanese woman who had been treated for rectal adenocarcinoma (Dukes C, stage IIIb) and who was diagnosed with primary uterine cervical carcinoma (FIGO stage Ib2) two years later. A radical hysterectomy was performed and the surgical specimen showed metastatic adenocarcinoma of the uterine cervix from rectal cancer without direct extension. Immunohistochemical staining was positive for cytokeratin 20 and CDX2, and negative for cytokeratin 7. Immunohistochemical staining is important for distinguishing between primary and secondary adenocarcinomas of the cervix, but histologic findings alone are not always adequate to establish the site of the primary lesion. The distinction between primary and secondary adenocarcinomas of the cervix is important for patient management and prognosis. Therefore, the possibility of metastatic adenocarcinoma should be considered whenever a diagnosis of adenocarcinoma of the cervix is received.


Cite this paper
Matsuura, M. , Tamate, M. , Suzuki, M. , Mariya, T. , Takada, S. , Tabuchi, Y. , Teramoto, M. , Satohisa, S. , Tanaka, R. , Iwasaki, M. , Fukunaka, K. , Fukunaka, N. , Tanaka, S. and Saito, T. (2014) Metastatic Carcinoma of the Uterine Cervix from Rectal Carcinoma: A Case Report and Review of the Literature. Open Journal of Obstetrics and Gynecology, 4, 617-620. doi: 10.4236/ojog.2014.410085.
References
[1]   Kim, H.S. and Underwood D. (1991) Adenocarcinomas in the Cervicovaginal Papanicolaou Smear: An Analysis of a 12-Year Experience. Diagnostic Cytopathology, 7, 119-124.
http://dx.doi.org/10.1002/dc.2840070203

[2]   Shingleton, H.M., Gore, H., Bradley, D.H. and Soong, S.J. (1981) Adenocarcinoma of the Cervix. Clinical Evaluation and Pathologic Features. American Journal of Obstetrics Gynecology, 139, 799-814.

[3]   Buckley, C. and Fox, H. (1992) Pathology of Clinical Invasive Carcinoma of Cervix. Churchill Livingstone, Edinburgh.

[4]   Childs, A.J., Burke, 2nd, J.J., Perry, M.Y., Check, W.E. and Gallup, D.G. (2005) Recurrent Colorectal Carcinoma Detected by Routine Cervicovaginal Papanicolaou Smear Testing. Journal of Lower Genital Tract Disease, 9, 236-238. http://dx.doi.org/10.1097/01.lgt.0000179865.98068.32

[5]   Nakagami, K., Takahashi, T., Sugitani, K., Sasaki, T., Ohwada, S. and Morishita, Y. (1999) Uterine Cervix Metastasis from Rectal Carcinoma: A Case Report and a Review of the Literature. Japanese Journal of Clinical Oncology, 29, 640-642. http://dx.doi.org/10.1093/jjco/29.12.640

[6]   Lemoine, N.R. and Hall, P.A. (1986) Epithelial Tumors Metastatic to the Uterine Cervix: A Study of 33 Cases and Review of Literature. Cancer, 57, 2002-2005.
http://dx.doi.org/10.1002/1097-0142(19860515)57:10<2002::AID-CNCR2820571021>3.0.CO;2-L

[7]   Korhonen, M. and Stenback, F. (1984) Adenocarcinoma Metastatic to the Uterine Cervix. Gynecologic and Obstetric Investigation, 17, 57-65. http://dx.doi.org/10.1159/000299123

[8]   Mazur, M.T., Hsueh, S. and Gersell, D.J. (1984) Metastases to the Female Genital Tract: Analysis of 325 Cases. Cancer, 53, 1978-1984.
http://dx.doi.org/10.1002/1097-0142(19840501)53:9<1978::AID-CNCR2820530929>3.0.CO;2-1

[9]   Sozen, I., Small, L., Kowalski, M., Mayo, A.W. and Hurwitz, C.A. (2005) Adenocarcinoma of the Cervix Metastatic from a Colon Primary and Diagnosed from a Routine Pap Smear in a 17-Year-Old Woman: A Case Report. The Journal of Reproductive Medicine, 50, 793-795.

[10]   Mulvany, N.J., Nirenberg, A. and Oster, A.G. (1996) Non-Primary Cervical Adenocarcinomas. Pathology, 28, 293-297. http://dx.doi.org/10.1080/00313029600169214

[11]   William, P. and Abraham, M. (1962) Adenocarcinoma of the Cervix. American Journal of Obstetrics Gynecology, 84, 367-374.

[12]   Zhang, Y.C., Zhang, P.F. and Wei, Y.H. (1983) Metastatic Carcinoma of the Cervix Uteri from the Gastrointestinal Tract. Gynecologic Oncology, 15, 287-290.
http://dx.doi.org/10.1016/0090-8258(83)90084-7

[13]   Eposito, J.M., Zarou, D.M. and Zarou, G.S. (1965) Extragenital Adenocarcinoma Metastatic to the Cervix Uteri: A Diagnostic Problem. American Journal of Obstetrics Gynecology, 92, 792-795.

[14]   Daw, E. (1972) Extragenital Adenocarcinoma Metastatic to the Cervix Uteri. American Journal of Obstetrics Gynecology, 114, 1104-1105.

[15]   Trastour, C., Rahili, A. and Chevallier, A. (2007) Metastasis to the Uterine Cervix from a Rectal Cancer. European Journal of Obstetrics. Gynecology and Reproductive Biology, 130, 137-138.
http://dx.doi.org/10.1016/j.ejogrb.2005.12.028

[16]   Millaire, M., Alobaid, A., Gariepy, G. and Gauthier, P. (2005) Metastatic Adenocarcinoma of the Cervix: A Case Report. Journal of Obstetrics Gynaecology, 27, 1113-1116.

[17]   Wallach, J.B. and Edberg, S. (1959) Carcinoma Metastatic to the Uterine Cervix. American Journal of Obstetrics Gynecology, 77, 990-995.

[18]   Kumar, N.B. and Hart, W.R. (1982) Metastases to the Uterine Corpus from Extragenital Cancers: A Clinicopathologic Study of 63 Cases. Cancer, 50, 2163-2169.
http://dx.doi.org/10.1002/1097-0142(19821115)50:10<2163::AID-CNCR2820501032>3.0.CO;2-F

[19]   Tango, M., Seto, T. and Watanabe, K. (1998) The Cellular Manifestations of Metastatic Adenocarcinoma of the Uterine Cervix. IRYO, 52, 534-538 (Japanese).

[20]   Suzuki, T., Ito, E., Takehara, M., Koizumi, M., Takeda, T., Fukunaka, N. and Kudo, R. (1997) A Study on Cytology and Histology of Metastatic Uterine Cancer. Journal of the Japanese Society of Clinical Cytology, 36, 167-173 (Japanese). http://dx.doi.org/10.5795/jjscc.36.167

 
 
Top