Nipple adenoma is a rare
benign condition that simulates malignancy. A 37-year-old woman presented with
unilateral bloody nipple discharge for 1-year duration followed by severe
nipple erosion. As biopsy revealed nipple adenoma and therefore, complete local
excision was done. The final histopathology showed florid papillomatosis which
was adequately excised. Nipple adenoma although rare entity this should be
included in the differential diagnosis of any nipple erosion such as carcinoma
and Paget’s disease of the breast specially when associated with bloody
discharge in premenopausal women.
Cite this paper
Abbas, A. , Al-Zaher, A. , El Arini, A. and Chaudhry, I. (2014) Adenoma of the Nipple, Mimicking Paget’s Disease of the Breast: Report of a Case. Advances in Breast Cancer Research
, 96-99. doi: 10.4236/abcr.2014.33014
 Kijima, Y., Matsukita, S., Yoshinaka, H., Owaki, T. and Aikou, T. (2006) Adenoma of the Nipple: Report of a Case. Breast Cancer, 13, 95-99. http://dx.doi.org/10.2325/jbcs.13.95
 Carter, E. and Dyess, D.L. (2004) Infiltrating Syringomatous Adenoma of the Nipple: A Case Report and 20-Year Retrospective Review. The Breast Journal, 10, 443-447. http://dx.doi.org/10.1111/j.1075-122X.2004.21518.x
 Tavassoli, F.A. and Devillee, P. Editors (2003) World Health Organisation Classification of Tumours: Pathology and Genetics of Tumours of the Breast and Female Genital Organs. IARC Press, Lyon.
 Healy, C.E., Dijikstra, B., Walsh, M., Hill, A.D. and Murphy, J. (2003) Nipple Adenoma: A Differential Diagnosis for Paget’s Disease. The Breast Journal, 9, 325-326. http://dx.doi.org/10.1046/j.1524-4741.2003.09417.x
 Sato. T., Muto, I., Hasegawa, M., Aono, T., Okada, T., Tamura, T., et al. (2007) A Rare Case of Invasive Ductal Carcinoma with Hyperprolactinemia. Breast Cancer, 14, 302-306. http://dx.doi.org/10.2325/jbcs.14.302
 Jones, M.W. and Tavassoli, F.A. (1995) Co-Existance of Nipple Duct Adenoma and Breast Carcinoma: A Clinicopathologic Study of 5 Cases and Review of Literature. Modern Pathology, 8, 633-636.
 Rosen, P.P. (1983) Syringomatous Adenoma of the Nipple. The American Journal of Surgical Pathology, 7, 739-745.
 Rosen, P.P. (2009) Rosen’s Breast Pathology. 3rd Edition, Lippincott William & Wilkins, Philadelphia.
 Da Costa, D., Taddese, A., Cure, M.L., Gerson, G., Poppiti Jr., R. and Esserman, L. (2007) Common and Unusual Diseases of the Nipple-Areolar Complex. Radiographics, 27, S65-S77. http://dx.doi.org/10.1148/rg.27si075512
 Montemarano, A.D., Sau, P. and James, W.D. (1995) Superficial Papillary Adenomatosis of the Nipple: A Case Report and Review of the Literature. Journal of the American Academy of Dermatology, 33, 871-875.
 Tavassoli, F.A. (1999) Pathology of the Breast. 2nd Edition, Appleton & Lange, Stamford.
 Afetab, K., Indrees, R., Rauf, F. and Kayani, N. (2010) Nipple Adenoma of Breast: A Masquerader of Malignancy. Journal of the College of Physicians and Surgeons Pakistan, 20, 472-474.
 Chang, C.K., Jacobs, I.A., Calilao, G. and Salti, G.I. (2003) Metastatic Infiltrating Syringomatous Adenoma of the Breast. Archives of Pathology Laboratory Medicine, 127, E155-E156.