JCPT  Vol.4 No.3 , July 2014
Synthesis and X-Ray Structure of Important Anticancer Nucleosides Intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5- (3-bromo-5-(methoxycarbonyl)- 1H-1,2,4-triazol-1-yl)tetrahydrofuran- 3,4-diyl Diacetate
ABSTRACT
An important anticancer nucleosides intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5-(3-bromo-5-(methoxycar-bonyl)-1H-1,2,4-triazol-1-yl)tetrahydrofuran-3,4-diyl diacetate was synthesized by directly coupling the bromotriazole with the protected ribose sugar, and have given the corresponding product in moderate yield. Its structure and conformation were confirmed by single crystal X-ray diffraction.

Cite this paper
Liu, Y. , Tian, G. , Ge, H. , Cao, X. , Hu, D. and Zhang, D. (2014) Synthesis and X-Ray Structure of Important Anticancer Nucleosides Intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5- (3-bromo-5-(methoxycarbonyl)- 1H-1,2,4-triazol-1-yl)tetrahydrofuran- 3,4-diyl Diacetate. Journal of Crystallization Process and Technology, 4, 140-144. doi: 10.4236/jcpt.2014.43018.
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