Health  Vol.3 No.4 , April 2011
Massive carcinoma of the cornea in an immunocompetent patient
ABSTRACT
A case of massive well-differentiated, superficially invasive, squamous cell carcinoma of the cornea is described. This patient did not have any common identifiable risk factors in the development of SCC of the ocular surface, such as excessive solar exposure, HPV infection, immunocompromised state, or chronic ocular irritation. A perforating injury in the cornea of the same eye had occurred 11 years before. The possible role of trauma in causing subsequent neoplastic development is discussed, as well as the immunohistochemical results for p53 and p63.

Cite this paper
nullPecorella, I. , Grenga, P. and Maria Vingolo, E. (2011) Massive carcinoma of the cornea in an immunocompetent patient. Health, 3, 245-248. doi: 10.4236/health.2011.34043.
References
[1]   Lee, G.A. and Hirst, L.W. (1997) Retrospective study of ocular surface squamous neoplasia. Aust NZJ Ophthalmol, 25, 269-276. doi:10.1111/j.1442-9071.1997.tb01514.x

[2]   Chikama, T., Liu, C.Y., Meij, J.T.A., Hayashi, Y., Wang, I.J., Yang, L., Nishida, T. and Kao, W.W.Y. (2008) Excess FGF-7 in corneal epithelium causes corneal intraepithelial neoplasia in young mice and epithelium hyperplasia in adult mice. Am J Pathol, 172, 638-649. doi:10.2353/ajpath.2008.070897

[3]   Toth, J., Karcioglu, Z.A., Moshfeghi, A.A., Issa, T.M., Al-Ma’ani, J.R. and Patel, K.V. (2000) Correlation between HPV positivity and p53 gene mutation in conjunctival squamous cell carcinoma. Cornea, 19, 159-162. doi:10.1097/00003226-200003000-00007

[4]   McKelvie, P.A., Daniell, M., McNab, A., Loughnan, M. and Santamaria, J.D. (2002) Squamous cell carcinoma of the conjunctiva: a series of 26 cases. Br J Ophthalmol, 86, 168-173. doi:10.1136/bjo.86.2.168

[5]   Auw-Haedrich, C., Sundmacher, R., Freudenberg, N., Spelsberg, H., Feltgen, N., Maier, P. and Reinhard, T. (2006) Expression of p63 in conjunctival intraepithelial neoplasia and squamous cell carcinoma. Graefe’s Arch Clin Exp Ophthalmol, 244, 96-103. doi:10.1007/s00417-005-0025-4

[6]   Pe’er, J. (2005) Ocular surface squamous neoplasia. Ophthalmol Clin N Am, 18, 1-13.

[7]   Martins-Green, M., Boudreau, N. and Bissell, M.J. (1994) Inflammation is responsible for the development of wound-induced tumors in chickens infected with Rous sarcoma virus. Cancer Res, 54, 4334-4341.

[8]   van den Hooff, A. (1988) Stromal involvement in malignant growth. Adv Cancer Res, 50, 159-196. doi:10.1016/S0065-230X(08)60437-6

[9]   Usui, Y., Waring, G.O., See, R.F. and Rao, N.A. (2004) Bilateral ocular surface squamous cell neoplasia: a clinicopathological case report. Br J Ophthalmol, 88, 595-596. doi:10.1136/bjo.2003.029710

 
 
Top