JBBS  Vol.4 No.6 , June 2014
An fNIRS-Based Study on Prefrontal Cortex Activity during a Virtual Shopping Test with Different Task Difficulties in Brain-Damaged Patients
Abstract: We developed a Virtual Shopping Test with three different task levels for assessment of daily cognitive function using virtual reality technology. The objective of present study was to investigate the difference on task performance, brain activation and subjective assessment in relation to the difficulty levels of the tasks. Subjects were asked to buy specific 2 items in Task 1, 4 items in Task 2, and 6 items in Task 3 at a virtual mall. The tasks and questionnaires were conducted on 10 convalescent brain-damaged patients and 6 healthy young adults. Hemodynamic changes in the prefrontal cortex (PFC) during activation due to the tasks were examined using functional near-infrared spectroscopy. As the result, the mean total time was significantly longer for the patients than for healthy subjects. PFC showed a greater response for related Task 2 than Task 1 in shopping and moving phase in patient group. The patients evaluated Tasks 1 and 2 are more difficult and bring more psychological load than healthy adults subjectively. That is, although the healthy adults did not show large difference in their task performances as well as PFC responses, they can evaluate the differences between three task levels, subjectively, while which could not be for the patients means that patients could not distinguish the difference of the tasks, subjectively. The results suggest that 4-item shopping task might be enough difficulty level that causes brain activation for the brain-damaged patients.
Cite this paper: Okahashi, S. , Mizumoto, H. , Komae, A. , Ueno, K. , Yokoyama, M. , Nagano, A. , Seki, K. , Futaki, T. and Luo, Z. (2014) An fNIRS-Based Study on Prefrontal Cortex Activity during a Virtual Shopping Test with Different Task Difficulties in Brain-Damaged Patients. Journal of Behavioral and Brain Science, 4, 247-255. doi: 10.4236/jbbs.2014.46026.

[1]   Fortin, S., Godbout, L. and Braun, C.M. (2003) Cognitive Structure of Executive Deficits in Frontally Lesioned Head Trauma Patients Performing Activities of Daily Living. Cortex, 39, 273-291.

[2]   Chevignard, M., Pillon, B., Pradat-Diehl, P., Taillefer, C., Rousseau, S., Le Bras, C. and Dubois, B. (2000) An Ecological Approach to Planning Dysfunction: Script Execution. Cortex, 36, 649-669.

[3]   Cicerone, K.D., Langenbahn, D.M., Braden, C., Malec, J.F., Kalmar, K., Fraas, M., Felicetti, T., Laatsch, L., Harley, J.P., Bergquist, T., Azulay, J., Cantor, J. and Ashman, T. (2011) Evidence-Based Cognitive Rehabilitation: Updated Review of the Literature from 2003 through 2008. Archives of Physical Medicine and Rehabilitation, 92, 519-530.

[4]   Kang, Y., Ku, J., Han, K., Kim, S., Yu, T., Lee, J., and Park, C. (2008) Development and Clinical Trial of Virtual Reality-Based Cognitive Assessment in People with Stroke: Preliminary Study. CyberPsychology & Behavior, 11, 329-339.

[5]   Knight, R.G., Titov, N. and Crawford, M. (2006) The Effects of Distraction on Prospective Remembering Following Traumatic Brain Injury Assessed in a Simulated Naturalistic Environment. International Psychogeriatrics, 12, 8-16.

[6]   Zhang, L., Abreu, B.C., Seale, G.S., Masel, B., Christiansen, C.H. and Ottenbacher, K.J. (2003) A Virtual Reality Environment for Evaluation of a Daily Living Skill in Brain Injury Rehabilitation: Reliability and Validity. Archives of Physical Medicine and Rehabilitation, 84, 1118-1124.

[7]   Okahashi, S., Seki, K., Nagano, A., Luo, Z., Kojima, M. and Futaki, T. (2013) A Virtual Shopping Test for Realistic Assessment of Cognitive Function. Journal of NeuroEngineering and Rehabilitation, 10, 1, 59.

[8]   Gagnon, L., Yucel, M.A., Dehaes, M., Cooper, R.J., Perdue, K.L., Selb, J., Huppert, T.J., Hoge, R.D. and Boas, D.A. (2012) Quantification of the Cortical Contribution to the NIRS Signal over the Motor Cortex Using Concurrent NIRS-fMRI Measurements. Neuroimage, 59, 3933-3940.

[9]   Villringer, A. and Chance, B. (1997) Non-Invasive Optical Spectroscopy and Imaging of Human Brain Function. Trends in Neurosciences, 20, 435-442.

[10]   Miyai, I., Yagura, H., Hatakenaka, M., Oda, I., Konishi, I. and Kubota, K. (2003) Longitudinal Optical Imaging Study for Locomotor Recovery after Stroke. Stroke, 34, 2866-2870.

[11]   Moriguchi, Y. and Hiraki, K. (2013) Prefrontal Cortex and Executive Function in Young Children: A Review of Nirsstudies. Frontiers in Human Neuroscience, 7, 867.

[12]   Godefroy, O. (2003) Frontal Syndrome and Disorders of Executive Functions. Journal of Neurology, 250, 1-6.

[13]   Smith, A. (1982) Symbol Digit Modalities Test: Manual. Western Psychological Services, Los Angeles.

[14]   Beck, L.H., Bransome Jr., E.D., Mirsky, A.F., Rosvold, H.E. and Sarason, I. (1956) A Continuous Performance Test of Brain Damage. J Consult Psychol, 20, 343-350.

[15]   Ishiai, S. (1999) Behavioural Inattention Test. Japanese Edition, Shinkoh Igaku Shuppan Co., Ltd., Tokyo.

[16]   Wilson, B.A., Cockburn, J. and Baddeley, A. (1985) Rivermead Behavioural Memory Test. Thames Valley Test Company, London.

[17]   Kazui, H., Hirono, N., Hashimoto, M., Nakano, Y., Matsumoto, K., Takatsuki, Y., Mori, E., Ikejiri, Y. and Takeda, M. (2006) Symptoms Underlying Unawareness of Memory Impairment in Patients with Mild Alzheimer’s Disease. Journal of Geriatric Psychiatry and Neurology, 19, 3-12.

[18]   Wilson, B.A., Alderman, N., Burgess, P., Emslie, H. and Evans, J. (1966) Behavioural Assessment of the Dysexecutive Syndrome: Test Manual. Thames Valley Test Company, London.

[19]   Toichi, M., Findling, R.L., Kubota, Y., Calabrese, J.R., Wiznitzer, M., McNamara, N.K. and Yamamoto, K. (2004) Hemodynamic Differences in the Activation of the Prefrontal Cortex: Attention vs. Higher Cognitive Processing. Neuropsychologia, 42, 698-706.